Article
Chemistry, Multidisciplinary
Rivkah Rogawski, Adi Rogel, Itai Bloch, Maayan Gal, Amnon Horovitz, Nir London, Michal Sharon
Summary: Researchers have developed a method based on native mass spectrometry for analyzing drug uptake and target engagement in cellular contexts. This approach utilizes direct MS for label-free studies of protein-drug binding in human cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Eleanor L. Brightbill, Katherine T. Young, Hilena F. Gezahagne, Decarle S. Jin, Bryce Hitchcock, Eric M. Vogel
Summary: The study found that the substrate supporting graphene has a significant impact on protein adhesion, with more hydrophobic substrates leading to greater adsorption. Additionally, the effect was only observed with monolayer graphene.
Review
Chemistry, Analytical
Xiaojin Zhang, Meihua Lin, Yu Dai, Fan Xia
Summary: Nanoporesensing technology is a promising analysis method with various advantages such as simplicity, high sensitivity, fast output, and label-free detection. It has been widely used in protein analysis, gene sequencing, biomarker detection, and other fields. By utilizing the confined space of the nanopore, this technology enables real-time tracking of dynamic interactions and chemical reactions at the single-molecule level, providing insights into the mechanisms of these processes. This paper reviews the development of biological nanopores and solid-state nanopores/nanochannels in stochastic sensing of dynamic interactions and chemical reactions, aiming to stimulate researchers' interest and promote the advancement of this field.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Sergei M. M. Butorin, David K. K. Shuh
Summary: The electronic structure and chemical state of Am binary oxides and Am-doped UO2 were studied using X-ray absorption spectroscopy. The Am 5f states were analyzed and their bonding with oxygen states was examined. The results were supported by AIM calculations, which considered the interaction between 5f electrons and the core hole. The sensitivity of Am 4d X-ray absorption lines to the chemical state of Am was demonstrated.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Chase Austyn Brisbois, Monica Olvera de la Cruz
Summary: The dynamic motion caused by precessing magnetic fields can lead to far-from-equilibrium states in matter. We predict the existence of 1D periodic ordering in systems of precessing rods when the magnetic interactions between rods are insignificant. The precession angle of the rods is determined by the field's precession angle and the ratio of the field's precession frequency to the characteristic response frequency of the rods. Our work, including molecular dynamics simulations and steric modeling, demonstrates how steric interactions drive rods from a disordered phase to a layered phase, and how minimizing unfavorable steric interactions leads to phase separation in binary mixtures. This research contributes to the understanding and control of out-of-equilibrium soft matter systems.
Article
Chemistry, Physical
Q. Peng, C. C. Zheng, X. Chen, R. X. Wang, S. J. Xu, X. T. Ge, D. Ding, Z. M. Gong, J. Q. Ning, R. Y. Zhang
Summary: This article investigates the local heating effects induced by laser irradiation in mechanically exfoliated WS2 monolayers and characterizes the resulting inhomogeneous temperature field using photoluminescence spectroscopy. By examining the dependence of excitonic emission energy on temperature, a local temperature up to 213 degrees C was found in the central region of the irradiated area in vacuum. Optical methods like this can be applied to measure local heating effects in 2D semiconductors and van der Waals devices.
APPLIED SURFACE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Ji Eun Lee, Joonyoung Choi, Taek Sun Jung, Jong Hyuk Kim, Young Jai Choi, Kyung Ik Sim, Younjung Jo, Jae Hoon Kim
Summary: Time-reversal symmetry breaking by an external magnetic field can lead to a novel quantum state called the gapless superconducting state. Here, the authors use magneto-terahertz spectroscopy to study the gapless superconductivity of thin niobium films. They observe a Lifshitz topological phase transition and magnetic pair-breaking effects, challenging traditional perturbative theories and opening the door to further exploration of the gapless superconducting state.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Chemical
Fufeng Liu, Luying Jiang, Jingcheng Sang, Fuping Lu, Li Li
Summary: The interaction between Amyloid O-protein (AO) and Tau, two pathogenic proteins associated with Alzheimer's disease (AD), was investigated. Docking and molecular dynamics simulations revealed that the AO pentamer and Tau pentamer can form stable hybrid decamer structures, with the "part-in" conformation being the most stable. The binding energy between AO and Tau in the part-in structure was approximately -759.77 kJ/mol. This study provides insights into the molecular mechanisms of the cross-interactions between AO and Tau implicated in AD.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Kota Ishihara, Masaki Roppongi, Masayuki Kobayashi, Kumpei Imamura, Yuta Mizukami, Hironori Sakai, Petr Opletal, Yoshifumi Tokiwa, Yoshinori Haga, Kenichiro Hashimoto, Takasada Shibauchi
Summary: Evidence consistent with chiral B-3u+iA(u) spin-triplet superconductivity in UTe2 is found through magnetic penetration depth measurements.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Upneet Kaur, Jennifer C. Lee
Summary: The research highlights the importance of alpha-synuclein's interactions with cellular membranes for its physiological and pathological functions, revealing the effects of the chemical nature of phospholipid headgroups on the interplay among membrane remodeling, protein structure, and alpha-syn amyloid formation.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
L. Y. Shi, X. M. Wang, R. D. Zhong, Z. X. Wang, T. C. Hu, S. J. Zhang, Q. M. Liu, T. Dong, F. Wang, N. L. Wang
Summary: The search for Kitaev quantum spin liquids (QSLs) is a fascinating yet challenging problem, with potential candidates being explored in various materials with strong spin-orbit coupling. Recent theoretical studies proposed Co-based honeycomb materials as promising candidates for a Kitaev QSL. Experimental studies on BaCo2(AsO4)(2) suggested proximity to a Kitaev QSL, but further research showed that the field-induced state in the low-temperature region is not a Kitaev QSL. Comparisons with the widely studied RuCl3 candidate were made to address similarities in magnetic excitations.
Article
Materials Science, Multidisciplinary
B. Kressdorf, T. Meyer, M. ten Brink, C. Seick, S. Melles, N. Ottinger, T. Titze, H. Meer, A. Weisser, J. Hoffmann, S. Mathias, H. Ulrichs, D. Steil, M. Seibt, P. E. Bloechl, C. Jooss
Summary: The phase diagram of Pr(1-x)CaNnO(3) (PCMO) has been modified for x <= 0.3, suggesting a reevaluation of the phase diagram of other manganites in that doping region. The orbital-order phase transition towards lower temperature based on anomalies observed in physical properties challenges a well-established and long-accepted picture.
Article
Chemistry, Multidisciplinary
Cheng Zong, Chi Zhang, Peng Lin, Jiaze Yin, Yeran Bai, Haonan Lin, Bin Ren, Ji-Xin Cheng
Summary: The EPRM technique utilizes a potential-dependent nonlinear photothermal signal to map electrochemical processes with sub-micron spatial resolution, revealing the evolution of surface species on the Pt surface. It allows for real-time imaging with a faster imaging speed, enabling broad applications in catalysis, energy storage, and light harvest systems.
Article
Materials Science, Multidisciplinary
D. Koumoulis, J. P. Scheifers, B. P. T. Fokwa, L. -s. Bouchard
Summary: The ordering of boron in the Sc2Ir6-xNixB series of intermetallic borides is affected by Ni substitution, as studied using 11B-NMR. The substitution of Ni leads to phase separation at the nanoscale between ordered and disordered borides. The behavior of the boron impurities at x = 3 and x = 5 is characterized by different temperature dependencies of the spin-lattice relaxation rates (T_ 1 1 ), indicating different relaxation mechanisms.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Chemistry, Physical
Julian Lee, Kyle Cotter, Ibrahim Elsadek, Matthew J. Comstock, Steve Presse
Summary: We investigated the hydrodynamic coupling between neighboring micro-beads in a dual optical trap system, which allowed us to control the coupling degree and measure the time-dependent trajectories of the entrained beads. Experimental results of a probe bead's average trajectory, entrained by the motion of a neighboring scan bead, were compared with theoretical computations, demonstrating the significance of viscous coupling and determining the relaxation timescales of the probe bead. These findings provide direct experimental evidence for hydrodynamic coupling at larger scales and longer timescales, which are relevant to hydrodynamic-assisted colloidal assembly and improving the resolution of optical tweezers. We conducted the experiments with three different bead setups.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Biochemical Research Methods
Sabine Richert, Claudia E. Tait, Christiane R. Timmel
JOURNAL OF MAGNETIC RESONANCE
(2017)
Article
Chemistry, Physical
Alan M. Lewis, Thomas P. Fay, David E. Manolopoulos, Christian Kerpal, Sabine Richert, Christiane R. Timmel
JOURNAL OF CHEMICAL PHYSICS
(2018)
Article
Chemistry, Physical
Sabrina Weickert, Torben Seitz, William K. Myers, Christiane R. Timmel, Malte Drescher, Valentin Wittmann
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Physical
Maria Giulia Dal Farra, Sabine Richert, Caterina Martin, Charles Larminie, Marina Gobbo, Elisabetta Bergantino, Christiane R. Timmel, Alice M. Bowen, Marilena Di Valentin
Article
Chemistry, Physical
Gabriel Moise, Lara Tejerina, Michel Rickhaus, Harry L. Anderson, Christiane R. Timmel
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2019)
Article
Multidisciplinary Sciences
Christian Kerpal, Sabine Richert, Jonathan G. Storey, Smitha Pillai, Paul A. Liddell, Devens Gust, Stuart R. Mackenzie, P. J. Hore, Christiane R. Timmel
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Physical
Claudia E. Avalos, Sabine Richert, Etienne Socie, Ganesan Karthikeyan, Gilles Casano, Gabriele Stevanato, Dominik J. Kubicki, Jacques E. Moser, Christiane R. Timmel, Moreno Lelli, Aaron J. Rossini, Olivier Ouari, Lyndon Emsley
JOURNAL OF PHYSICAL CHEMISTRY A
(2020)
Article
Chemistry, Physical
Arnau Bertran, Kevin B. Henbest, Marta De Zotti, Marina Gobbo, Christiane R. Timmel, Marilena Di Valentin, Alice M. Bowen
Summary: LITTER is a new technique that measures the dipolar interaction between two photoexcited triplet states, enabling the determination of distance and angular distributions on a nanometer scale. It removes the need for a permanent paramagnetic moiety, making it more suitable for in-cell applications and facilitating distance determination in unmodified macromolecular systems. LITTER also has the potential to enable direct comparison with Forster resonance energy transfer and combination with microscopy inside cells.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Ashley J. Redman, Gabriel Moise, Sabine Richert, Erin J. Viere, William K. Myers, Michael J. Therien, Christiane R. Timmel
Summary: The study investigates the significance of photoexcited triplet states of porphyrin in various fields and the key spectroscopic tool for quantifying spin delocalization. The challenges and potential developments of the methodology for analyzing experimental data of a series of porphyrin monomers are discussed using EPR and quantum chemical calculations.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Physical
Alice M. Bowen, Arnau Bertran, Kevin B. Henbest, Marina Gobbo, Christiane R. Timmel, Marilena Di Valentin
Summary: The study explores the potential of orientation-resolved pulsed dipolar spectroscopy (PDS) in light-induced experiments, using triplets as spin-active moieties for studying biochemical systems. Analysis of orientation selection effects in PDS provides both distance and mutual orientation information, with complementary information from different light-induced techniques yielding atomic-level structural information. The study introduces a 2D frequency-correlated laser-induced magnetic dipolar spectrum, allowing for monitoring of complete orientation dependence in a single experiment, as well as an orientation-independent analysis for determining distance distribution.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Multidisciplinary Sciences
Jingjing Xu, Lauren E. Jarocha, Tilo Zollitsch, Marcin Konowalczyk, Kevin B. Henbest, Sabine Richert, Matthew J. Golesworthy, Jessica Schmidt, Victoire Dejean, Daniel J. C. Sowood, Marco Bassetto, Jiate Luo, Jessica R. Walton, Jessica Fleming, Yujing Wei, Tommy L. Pitcher, Gabriel Moise, Maike Herrmann, Hang Yin, Haijia Wu, Rabea Bartoelke, Stefanie J. Kaesehagen, Simon Horst, Glen Dautaj, Patrick D. F. Murton, Angela S. Gehrckens, Yogarany Chelliah, Joseph S. Takahashi, Karl-Wilhelm Koch, Stefan Weber, Ilia A. Solov'yov, Can Xie, Stuart R. Mackenzie, Christiane R. Timmel, Henrik Mouritsen, P. J. Hore
Summary: Night-migratory songbirds show remarkable navigation abilities using a light-dependent magnetic compass mechanism suggested to rely on quantum spin dynamics. Research reveals that the photochemistry of CRY4 from the night-migratory European robin is more sensitive to magnetic fields than from non-migratory bird species, with specific mutations showing the roles of flavin-tryptophan radical pairs.
Article
Chemistry, Multidisciplinary
Olav Schiemann, Caspar A. Heubach, Dinar Abdullin, Katrin Ackermann, Mykhailo Azarkh, Elena G. Bagryanskaya, Malte Drescher, Burkhard Endeward, Jack H. Freed, Laura Galazzo, Daniella Goldfarb, Tobias Hett, Laura Esteban Hofer, Luis Fabregas Ibanez, Eric J. Hustedt, Svetlana Kucher, Ilya Kuprov, Janet Eleanor Lovett, Andreas Meyer, Sharon Ruthstein, Sunil Saxena, Stefan Stoll, Christiane R. Timmel, Marilena Di Valentin, Hassane S. Mchaourab, Thomas F. Prisner, Bela Ernest Bode, Enrica Bordignon, Marina Bennati, Gunnar Jeschke
Summary: Distance distribution information obtained by pulsed dipolar EPR spectroscopy plays a crucial role in structural biology research, providing unique constraints for integrative structural modeling. Quality standards for sample preparation, measurements, data conversion, interpretation, and reporting have been defined to ensure the reliability of structural models and biological conclusions, with support from a multi-laboratory benchmark study and analysis of data sets with known distance distribution ground truth. The guidelines mainly focus on proteins labeled with nitroxides and double electron-electron resonance measurements, while also offering suggestions for similar cases.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Arnau Bertran, Laura Morbiato, Sara Aquilia, Laura Gabbatore, Marta De Zotti, Christiane R. Timmel, Marilena Di Valentin, Alice M. Bowen
Summary: In this study, we introduce a new photoswitchable spin label that can be used to investigate the orientational effects in pulsed electron paramagnetic resonance dipolar spectroscopy. Furthermore, experiments conducted at temperatures above liquid nitrogen eliminate the need for expensive cryogenic equipment.
Article
Chemistry, Multidisciplinary
Victoire Dejean, Marcin Konowalczyk, Jamie Gravell, Matthew J. Golesworthy, Catlin Gunn, Nils Pompe, Olivia Foster Vander Elst, Ke-Jie Tan, Mark Oxborrow, Dirk G. A. L. Aarts, Stuart R. Mackenzie, Christiane R. Timmel
Article
Chemistry, Physical
Nino Wili, Sabine Richert, Bart Limburg, Simon J. Clarke, Harry L. Anderson, Christiane R. Timmel, Gunnar Jeschke
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
