Article
Chemistry, Physical
Agata Paneth, Piotr Paneth
Summary: Although weak intermolecular interactions play a crucial role in key processes, their characterization is still lacking. Environmental and structural variations have been shown to influence chlorine isotope effects, which may obscure mechanistic interpretations and analytical protocols in dehalogenation processes.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Wen-Qi Tang, Ying-Jie Zhao, Ming Xu, Jin-Ya Xu, Sha-Sha Meng, Yun-Dong Yin, Qing-Hua Zhang, Lin Gu, Da-Huan Liu, Zhi-Yuan Gu
Summary: Control over the stacking modes of metal-organic framework (MOF) nanosheets can lead to excellent gas chromatographic separations. Different solvents can induce twisted stacking of nanosheets, while alkanes may result in untwisted stacking.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Sayan Sarkar, Pablo Ballester, Mark Spektor, Evgeny A. Kataev
Summary: The design of high-affinity synthetic host-guest complexes is crucial for constructing novel supramolecular assemblies, functional materials, molecular probes, artificial signal transduction events, and interfaces with the biological world. This review discusses recent achievements in designing 1:1 host-guest complexes with exceptional stabilities exceeding 10(6) M-1. The relationships between thermodynamic constants and structural parameters are analyzed, and the design features of high-affinity hosts are discussed, considering different solvents and noncovalent interactions for complex stabilization. Hints for future design of synthetic receptors with high affinity and selectivity are provided.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Lee E. Hunt, Susan A. Bourne, Mino R. Caira
Summary: The study investigates the formation of eight new crystalline complexes between methylated cyclodextrins and bioactive phenolic acids. The complexes were classified based on the extent of inclusion of the guest molecules within the cavity of the cyclodextrin molecules. The results revealed three full guest encapsulation compounds, three partial guest inclusion compounds, and two rare 'non-inclusion' compounds.
Review
Agriculture, Multidisciplinary
Wenjie Li, Weiwei Xu, Siyun Zhang, Jia Li, Juan Zhou, Demei Tian, Jing Cheng, Haibing Li
Summary: Significant progress has been made in the research on drug encapsulation and release based on supramolecular macrocycles, laying a solid foundation for the development of novel nanopesticide preparations.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Xi Yang, Di Yuan, Jinhong Hou, Adam C. Sedgwick, Suying Xu, Tony D. James, Leyu Wang
Summary: The field of supramolecular chemistry has rapidly expanded and become highly influential in various areas like biomedicine, energy materials, catalysis, and sensing. The combination of host/guest chemistry with functional inorganic nanoparticles has led to many new applications in drug delivery, bioimaging, and sensing. Recent progress in the development of organic/inorganic supramolecular nano-systems incorporating host/guest chemistry has been summarized, highlighting their applications in drug delivery, biological imaging, and sensing.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Michelle Ernst, Ganna Gryn'ova
Summary: This study presents a method for computing the strength and analyzing the nature of host-guest interactions in MOFs, finding that appropriately constructed clusters can reproduce key interactions in periodic models at a fraction of the computational cost. Host-guest interaction energies can be reliably computed using dispersion-corrected density functional theory methods.
Article
Chemistry, Multidisciplinary
Dilanka V. D. Walpita Kankanamalage, Jennifer H. T. Tran, Noah Beltrami, Kun Meng, Xiao Zhou, Pravin Pathak, Lyle Isaacs, Alexander L. Burin, Mehnaaz F. Ali, Janarthanan Jayawickramarajah
Summary: This study introduces a synthetic surrogate called host-guest-driven toehold-mediated strand displacement (HG-TMSD) that utilizes bioorthogonal interactions to control the process of DNA strand displacement. The HG-TMSD method can be finely modulated by changing the structure of the input sequence and can also be regulated by competing small-molecule guests. It can be integrated into functional devices for controlling enzyme activity and detecting specific microRNA.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Laurent Severy, Jacek Szczerbinski, Mert Taskin, Isik Tuncay, Fernanda Brandalise Nunes, Chiara Cignarella, Gabriele Tocci, Olivier Blacque, Jurg Osterwalder, Renato Zenobi, Marcella Iannuzzi, S. David Tilley
Summary: The study demonstrates a non-covalent 'click' chemistry approach to reversibly bind molecular electrocatalysts to electrode surfaces through host-guest complexation. This efficient method enables the replacement and reuse of molecular catalysts, enhancing the attractiveness of electrosynthetic systems.
Article
Chemistry, Multidisciplinary
Hector Fernandez-Caro, Alejandro Mendez-Ardoy, Javier Montenegro
Summary: The intracellular reconfiguration of nanoparticles by a host/guest mechanism with biocompatible oligomeric competitors has been achieved, allowing for the direct exchange of pendants at the surface of nanoparticles and the intracellular dynamic chemical reconfiguration of biocompatible colloidal systems.
Article
Materials Science, Multidisciplinary
Yongqi Sun, Yue Long, Huaqiang Cai, Kai Hou, Xingchao Li, Xuesen Zhang, Jinshan Li, Kai Song
Summary: The novel photo-responsive supramolecular hydrogel inverse opal material described in this communication can shift its structural color towards blue or red under blue or red light irradiation, respectively.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Polymer Science
Hao Ding, Sana T. Khan, Jingjing Liu, Luyi Sun
Summary: This study presents a novel gelation system based on host-guest interactions, with adamantyl groups acting as reversible crosslinkers within the beta-cyclodextrin polymer. The gelation process occurs quickly at room temperature, without the formation of covalent bonds, showing potential for further research in this area.
Article
Chemistry, Multidisciplinary
Benita Barton, Ulrich Senekal, Eric C. Hosten
Summary: In single-solvent recrystallization experiments, DED showed overwhelming selectivity for 4-methylanisole (4-MA) and can serve as an efficient host compound for the separation and purification of mixtures. The interaction between DED and 4-MA is achieved through two short stabilizing (host)C-O···π(guest) contacts.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Physical
Macarena Rojas-Poblete, Peter L. Rodriguez-Kessler, Raul Guajardo Maturana, Alvaro Munoz-Castro
Summary: Host-guest chemistry in materials science is advanced by studying coinage-metal pillarplexes, which show significant contributions from van der Waals and electrostatic interactions, particularly influenced by the pi-surface of the organic ligand backbone. The results suggest potential applications of lighter copper counterparts in forming inclusion complexes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Meng Xu, Jinsong Tao, Zhengjie Wei, Qian Cheng, Hongmei Yang, Simon Ming-Yuen Lee, Kathy Qian Luo, Wei Ge, Ruibing Wang, Ying Zheng
Summary: The clinical translation of anticancer nanomedicine is limited due to nonspecific accumulation and low targeting efficiency in tumor. A bioorthogonal targeting strategy based on supramolecular recognition between β-cyclodextrin-modified tumor cells and adamantane-modified nanomedicine was established. The host-guest interactions driven targeting process was visualized in vivo at the single-cell level for the first time, providing direct evidence of bioorthogonal homing effects.
