Article
Immunology
Marco Lebtig, Jasmin Scheurer, Marie Muenkel, Janna Becker, Effie Bastounis, Andreas Peschel, Dorothee Kretschmer
Summary: Keratinocytes play an important role in protecting the skin barrier by producing inflammatory modulators. Activation of the FPR2 receptor in keratinocytes promotes inflammation and cell proliferation, which is necessary for eliminating bacteria like Staphylococcus aureus from the skin.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Lena Staudenmaier, Jule Focken, Katja Schlatterer, Dorothee Kretschmer, Birgit Schittek
Summary: The study demonstrates that skin commensals also release membrane vesicles (MVs) in similar quantity and lipid content as pathogenic Staphylococcus aureus, providing protection against skin colonization by S. aureus. On the contrary, MVs released by S. aureus induce proinflammatory responses in human keratinocytes, recruit neutrophils, and enhance skin colonization. The level of induction is dependent on TLR2 and NFkB signaling pathways and correlates with the membrane lipid and protein A content of the MVs.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eulgi Lee, Kyungchan Min, Hyeok Ahn, Bu-nam Jeon, Shinyoung Park, Changhee Yun, Hyehee Jeon, Jae-sung Yeon, Hyun Kim, Hansoo Park
Summary: Disruption of skin microbial balance can worsen certain skin diseases. This study investigates the potential therapeutic effects of specific skin microbiomes in inhibiting harmful microbial formation and restoring skin barrier function, suggesting the activation of AhR and Nrf2 as a potential approach. The results demonstrate the ability of these microbiomes to reverse skin barrier damage through dual AhR/Nrf2 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Minke M. F. van Mierlo, Luba M. Pardo, Karin B. Fieten, Tim J. van den Broek, Frank H. J. Schuren, Michel van Geel, Suzanne G. M. A. Pasmans
Summary: This study found that filaggrin gene (FLG) mutations have a significant effect on the overall microbiome composition in children with difficult-to-treat atopic dermatitis (AD), but have a minor role in specific microbiomes.
Article
Allergy
Jihyun Kim, Byung Eui Kim, Evgeny Berdyshev, Irina Bronova, Lianghua Bin, Jaewoong Bae, Seokjin Kim, Hye-Young Kim, Un Ha Lee, Myoung Shin Kim, Hyunmi Kim, Jinyoung Lee, Clifton F. Hall, Jessica Hui-Beckman, Yunhee Chang, Anna Sofia Bronoff, Dasom Hwang, Hae-Young Lee, Elena Goleva, Kangmo Ahn, Donald Y. M. Leung
Summary: This study found that Staphylococcus aureus infection can cause skin barrier disruption in atopic dermatitis patients. Moreover, the study also found that S. aureus induces aberrant epidermal lipid composition and skin barrier dysfunction by inhibiting fatty acid elongase enzymes in epidermal cells.
Review
Allergy
Layla Bakaa, Jeffrey M. Pernica, Rachel J. Couban, Kelly Jo Tackett, Craig N. Burkhart, Liz Leins, Joanne Smart, Maria Teresa Garcia-Romero, Itzel Guadalupe Elizalde-Jimenez, Michael Herd, Rachel Netahe Asiniwasis, Mark Boguniewicz, Anna De Benedetto, Lina Chen, Kathy Ellison, Winfred Frazier, Matthew Greenhawt, Joey Huynh, Jennifer LeBovidge, Mary Laura Lind, Peter Lio, Monica O'Brien, Peck Y. Ong, Jonathan Silverberg, Jonathan M. Spergel, Julie Wang, Wendy Smith Begolka, Lynda Schneider, Derek K. Chu
Summary: In patients with moderate-to-severe atopic dermatitis, bleach baths likely improve clinician-reported severity, with approximately 10% of patients experiencing a 50% improvement. The impact on other patient-important outcomes remains uncertain. These findings highlight the need for further large-scale clinical trials.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Walter Dehority, Valerie J. Morley, Daryl B. Domman, Seth M. Daly, Kathleen D. Triplett, Kylie Disch, Rebekkah Varjabedian, Aimee Yousey, Parisa Mortaji, Deirdre Hill, Olufunmilola Oyebamiji, Yan Guo, Kurt Schwalm, Pamela R. Hall, Darrell Dinwiddie, Jon Femling
Summary: Pediatric osteoarticular infections caused by Staphylococcus aureus are genetically heterogeneous, with a higher prevalence of genes involved in immune evasion. However, overall virulence gene carriage is similar with infrequent mutations, suggesting that pathogenesis of these infections may be primarily regulated at transcriptional and/or translational levels.
Article
Allergy
Maria Chapsa, Henriette Roensch, Tobias Loewe, Florian Gunzer, Stefan Beissert, Andrea Bauer
Summary: This study investigated the prevalence of different bacterial colonisations in hand eczema (HE) patients and their association with disease severity, symptoms and aetiology. Results showed that the main colonisation in HE patients is with Staphylococcus aureus, which is associated with severe disease, acute symptoms and atopic aetiology. Commensal skin flora colonisation is associated with mild disease. These findings could provide clues for new therapeutic approaches.
CONTACT DERMATITIS
(2023)
Article
Multidisciplinary Sciences
Tomotaka Ohkubo, Yasuhiko Matsumoto, Otomi Cho, Yuki Ogasawara, Takashi Sugita
Summary: The proportion of Staphylococcus aureus in the skin microbiome is associated with the severity of inflammation in atopic dermatitis, and the balance between Staphylococcus epidermidis and S. aureus is crucial for maintaining healthy skin. Heat-treated culture supernatant of Delftia acidovorans inhibits the growth of S. epidermidis by inducing the production of reactive oxygen species via the TCA cycle.
Review
Dermatology
Junqin Liang, Fengxia Hu, Hongbo Tang, Fanhe Jiang, Yingbing Sang, Yongzhen Hong, Qian Wang, Kalibi Nuer, Xiaojing Kang
Summary: This study aimed to compare the effectiveness of different emollients in preventing infant atopic dermatitis (AD). The results showed that early application of emollients effectively prevented the development of AD in high-risk infants, with emollient emulsion being the optimal choice. However, subjects receiving emollients more frequently experienced adverse events.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Ming-Han Tsai, Chih-Yung Chiu, Kuan-Wen Su, Sui-Ling Liao, Hsiang-Ju Shih, Man-Chin Hua, Tsung-Chieh Yao, Shen-Hao Lai, Kuo-Wei Yeh, Li-Chen Chen, Jing-Long Huang
Summary: The study found that infants had the highest incidence of S. aureus colonization at 1 month of age, which decreased to a nadir at 12 months. Maternal smoking may increase the risk of infant S. aureus colonization. Horizontal transmission between mothers and infants may be the primary source of MRSA acquisition in early infancy.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Agnieszka Polecka, Andrzej Awchimkow, Natalia Owsianko, Anna Baran, Justyna Magdalena Hermanowicz, Iwona Flisiak
Summary: This study investigated the prevalence of hand eczema in the Polish female population and its association with disinfectant usage during the COVID-19 pandemic. The study found that hand eczema was more prevalent in younger adults, and increased disinfectant usage exacerbated the symptoms. Respondents with a dermatological history were more susceptible to new skin symptoms during the pandemic, and quality of life was significantly impacted.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Anna K. Raez, Federica Andreoni, Mathilde Boumasmoud, Judith Bergada-Pijuan, Tiziano A. Schweizer, Srikanth Mairpady Shambat, Barbara Hasse, Annelies S. Zinkernagel, Silvio D. Brugger
Summary: Staphylococcus aureus carriage is a risk factor for invasive infections, and the genetic elements and phenotypic adaptation traits favoring the transition from colonization to invasion are not well understood. Our study showed that colonizing and invasive isolates displayed similar adherence, hemolysis, reproductive fitness properties, antibiotic tolerance, and virulence, with minimal genetic differences. This further emphasized colonization as the major risk factor for invasive disease.
MICROBIOLOGY SPECTRUM
(2023)
Review
Multidisciplinary Sciences
Kirsten A. Berry, Mackenzie T. A. Verhoef, Allison C. Leonard, Georgina Cox
Summary: Staphylococcus aureus is a pathobiont capable of colonizing and infecting most tissues within the human body, relying on a complex and diverse arsenal of adhesins. Therapeutics targeting the S. aureus host-pathogen interaction remain understudied, and alternative approaches are crucial due to the increasing global threat of antimicrobial resistance. Developing antivirulence agents to neutralize virulence factors could reduce bacterial pathogenicity and the burden of S. aureus infections.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Young In Lee, Sang Gyu Lee, Jemin Kim, Sooyeon Choi, Inhee Jung, Ju Hee Lee
Summary: The novel emollient containing H.ECMTM liposome shows significant hydration and anti-inflammatory effects, improving skin conditions of dry and eczema-prone skin. The studies confirm its efficacy in reducing itching and restoring skin barrier integrity, making it a therapeutic option for such skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)