Article
Veterinary Sciences
Seok-Jin Kang, In-Byung Park, Taehoon Chun
Summary: The study found that PCV2 ORF5 increased the expression of RNF128 in infected PK15 cells, suppressing type I interferon production and enhancing PCV2 replication. This suggests that up-regulating RNF128 with PCV2 ORF5 can help the virus evade initial immune surveillance in porcine epithelial cells.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Tong Xu, Li-Shuang Deng, Zhi-Jie Jian, Lei Xu, Feng-Qin Li, Si-Yuan Lai, Yan-Ru Ai, Ling Zhu, Zhi-Wen Xu
Summary: This study reports the molecular detection of PCV4 in cats from Sichuan Province, China, confirming the presence of PCV4 in this species. The PCV4 strain from cats showed high nucleotide homology with strains from other species and clustered closely with a strain from a pig in Fujian Province, China.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xue Li, Si Chen, Guyu Niu, Xinwei Zhang, Weilong Ji, Ying Ren, Liying Zhang, Linzhu Ren
Summary: This study analyzed the genetic relationship between PCV4 and other circoviruses, and found that PCV4 is more similar to MiCV, suggesting a potential common origin or derivation from MiCV. This raises concerns about the potential threat of PCV4 to animals and even humans. Therefore, continuous monitoring of PCV4 infection and variation, as well as the establishment of prevention and treatment methods, is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Veterinary Sciences
Libin Wen, Kongwang He
Summary: PCV2, associated with PCVAD in pigs, has caused economic losses in the pig industry worldwide. Since its discovery in the late 1990s, PCV2 has evolved with new genotypes and recombination between different genotypes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Ning Li, Jing Liu, Jiali Qi, Feng Hao, Lei Xu, Kangkang Guo
Summary: The study reveals the genetic diversity of PCV2 in China, showing that PCV2b was initially dominant but shifted to PCV2d from 2009. This suggests a potential transition from PCV2b to PCV2d in 2009, similar to global patterns. Additionally, novel PCV2 strains were identified, highlighting the rich genetic diversity of PCV2 in China from 2000 to 2019.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Spectroscopy
Izabel C. V. P. Gogone, Glaucia H. Ferreira, Danielle Gava, Rejane Schaefer, Fabiola F. de Paula-Lopes, Raquel de A. Rocha, Flavia R. O. de Barros
Summary: The study evaluated Raman spectroscopy as a diagnostic tool for porcine parvovirus and porcine circovirus type 2, demonstrating its ability to effectively discriminate virus-infected cells and providing promising bases for future diagnostic applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Virology
Cui Lin, Jingyu Hu, Yadong Dai, Huandong Zhang, Kang Xu, Weiren Dong, Yan Yan, Xiran Peng, Jiyong Zhou, Jinyan Gu
Summary: Circovirus is the smallest virus to cause immune suppression in pigs. The nuclear entry and stability of the capsid protein (Cap) of porcine circovirus type 2 (PCV2) are crucial for its infection and replication. IPO5 acts as a host factor that maintains self-stability of PCV2 virions and promotes their nuclear import. By directly binding to Cap, IPO5 blocks proteasome degradation and facilitates PCV2 replication.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Dedong Wang, Lei Hou, Ying Ji, Jiali Xie, Jie Zhao, Ning Zhu, Xiaoyu Yang, Jianwei Zhou, Yongqiu Cui, Jinshuo Guo, Xufei Feng, Jue Liu
Summary: Porcine circovirus type 3 (PCV3) is a virus that causes a wide range of illnesses in pigs. This study revealed that PCV3 capsid protein interacts with nucleolin and degrades it, requiring the recruitment of the enzyme RNF34. Nucleolin degradation by PCV3 capsid protein occurs in the nucleolus. Additionally, nucleolin decreases PCV3 replication by promoting the release of interferon beta. These findings provide important insights into the mechanism by which nucleolin modulates PCV3 replication and offer a potential strategy for preventing and controlling PCV3 infection.
JOURNAL OF VIROLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Yanjin Wang, Shijie Yan, Yuting Ji, Yujie Yang, Ping Rui, Zengjun Ma, Hua-Ji Qiu, Tao Song
Summary: This study provides evidence of the widespread transmission of PCV4 among pigs and fur animals in Hebei Province, China, highlighting its potential threat to the fur animal farming industry. The findings also contribute to the understanding of the molecular epidemiology of PCV4 and its cross-species transmission.
Article
Immunology
Wen Zhang, Zhendong Fu, Hongyan Yin, Qingbing Han, Wenhui Fan, Fangkun Wang, Yingli Shang
Summary: PCV2 infection skews macrophages towards M1 status by reprogramming the expression of M1 and M2 associated genes. This skewing is regulated by activation of NF-κB and JNK signaling pathways for M1-associated genes and suppression of M2-associated genes through inhibition of JMJD3 expression. This modulation by PCV2 contributes to bacterial coinfection and viral pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jiangwei Song, Lei Hou, Dan Wang, Li Wei, Shanshan Zhu, Jing Wang, Rong Quan, Haijun Jiang, Ruihan Shi, Jue Liu
Summary: NPM1 interacts with PCV3 Cap and plays a crucial role in PCV3 replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Rajib Deb, Joyshikh Sonowal, Gyanendra Singh Sengar, Seema Rani Pegu, Manas Ranjan Praharaj, Waseem Akram Malla, Indra Singh, Ajay Kumar Yadav, Swaraj Rajkhowa, Pranab Jyoti Das, Jaya Bharati, Souvik Paul, Vivek Kumar Gupta
Summary: The goal of this study was to compare the global gene expression profile in pig cardiac tissues infected with porcine circovirus 2 (PCV2) and healthy cells. The study identified 196 significantly differentially expressed genes (DEGs) and revealed their involvement in biological pathways related to cardiac pathology.
Article
Immunology
Qingping Luo, Waqas Ahmed, Yichen Dai, Ali Mohsin, Haifeng Hang, Yingping Zhuang, Meijin Guo
Summary: The engineered PCV2 truncated capsid subunit Fc-fusion protein induced both cellular and humoral immune responses in mice, showing great potential for applications.
Article
Virology
Jianwei Zhou, Yongxia Wang, Linyi Zhou, Yonghui Qiu, Jie Zhao, Beining Dai, Xufei Feng, Lei Hou, Jue Liu
Summary: The interaction between PCV3 and PCV4 Cap proteins and host proteins was investigated. The results showed that various proteins directly interacted with the Cap proteins. Further analysis revealed that these proteins were mainly involved in ribosome biogenesis, nucleic acid binding, and RNA unwinding activities. The binding abilities of some of these proteins were experimentally verified, providing insights for further understanding the mechanisms of PCV3 and PCV4 infection.
Article
Microbiology
Haochun Pan, Changchao Huan, Yutong Hou, Ping Yan, Fan Yang, Luyao Jiang, Song Gao
Summary: The infection of porcine circovirus type 2 (PCV2) triggers the activation of the PERK pathway and leads to DNA damage. This study reveals that IGFBP3 may regulate DNA damage via ER stress to mediate PCV2 replication. The overexpression of IGFBP3 enhances PCV2 replication by activating the PERK/eIF2 alpha pathway-mediated induction of DNA damage. Targeting this pathway could be a potential antiviral strategy.
VETERINARY MICROBIOLOGY
(2023)
Article
Medical Laboratory Technology
Alexander Chan, Priyadarshini Kumar, Qi Gao, Jeeyeon Baik, Allison Sigler, Dory Londono, Ying Liu, Maria E. Arcila, Ahmet Dogan, Yanming Zhang, Mikhail Roshal, Wenbin Xiao
Summary: Lineage infidelity, characterized by abnormal immature B lineage output, is rare but detectable in patients with MDS and non-CML MPN. Most cases with abnormal B-lymphoblast populations remain stable or disappear, with only a small percentage progressing to B-ALL. Further investigation is needed to understand the underlying disease biology and its implications for patient management.
CYTOMETRY PART B-CLINICAL CYTOMETRY
(2023)
Article
Business
Yanming Zhang, Minhao Gu, Baofeng Huo
Summary: This study investigates the impact of IT usage and employee multi-skilling on the agility of the supply chain. The findings suggest that internal agility is the foundation of supply chain agility and can improve supplier and customer agility. IT usage is more significant than employee multi-skilling in facilitating supply chain agility. Both internal and supplier agility positively affect supply chain performance, while customer agility has no significant impact.
JOURNAL OF BUSINESS & INDUSTRIAL MARKETING
(2023)
Article
Hematology
Maximilian Stahl, Andriy Derkach, Noushin Farnoud, Jan Philipp Bewersdorf, Troy Robinson, Christopher Famulare, Christina Cho, Sean Devlin, Kamal Menghrajani, Minal A. Patel, Sheng F. Cai, Linde A. Miles, Robert L. Bowman, Mark B. Geyer, Andrew Dunbar, Zachary D. Epstein-Peterson, Erin McGovern, Jessica Schulman, Jacob L. Glass, Justin Taylor, Aaron D. Viny, Eytan M. Stein, Bartlomiej Getta, Maria E. Arcila, Qi Gao, Juliet Barker, Brian C. Shaffer, Esperanza B. Papadopoulos, Boglarka Gyurkocza, Miguel-Angel Perales, Omar Abdel-Wahab, Ross L. Levine, Sergio A. Giralt, Yanming Zhang, Wenbin Xiao, Nidhi Pai, Elli Papaemmanuil, Martin S. Tallman, Mikhail Roshal, Aaron D. Goldberg
Summary: Measurable residual disease (MRD) is a powerful prognostic factor in acute myeloid leukemia (AML). This study aims to identify pre-treatment molecular predictors of immunophenotypic MRD clearance in AML patients. The results showed that induction chemotherapy led to different MRD responses, with 35% achieving MRD- remission, 27% achieving MRD+ remission, and 38% having persistent disease. Subsequent therapy resulted in MRD conversion in 34% of MRD+ patients and 26% of patients with persistent disease. Specific gene mutations and karyotypic abnormalities were found to be associated with high or low rates of MRD- remission. Patients with fewer individual clones were more likely to achieve MRD- remission. Furthermore, the study demonstrated that achieving MRD- prior to allogeneic stem cell transplant (allo-SCT) was associated with favorable outcomes. Therefore, the inclusion of patients with specific baseline mutational patterns and high clone numbers in clinical trials should be considered.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Biophysics
Zhenzhen Yao, Bin Gu, Yanming Zhang, Jiaqian Qi, Jia Chen, Yang Xu, Feng Chen, Xiao Ma, Miao Miao, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Lei Yu, Depei Wu, Ying Wang
BONE MARROW TRANSPLANTATION
(2023)
Letter
Hematology
Ying Liu, Andriy Derkach, Natasha Lewis, Menglei Zhu, Yanming Zhang, Maria Arcila, Gilles Salles, Ahmet Dogan, Wenbin Xiao
Article
Engineering, Electrical & Electronic
Gaojing Zhang, Ming Su, Yanming Zhang, Anna Wang, Chengkang Pan
Summary: This article presents the design process of a beam-steering partially reflective surface (PRS) made up of C-shaped split-ring resonators (CSRRs). By analyzing the transmission characteristics of CSRRs with variable opening angles and orientations, spatially abrupt phase and magnitude are introduced over the PRS to reshape the wavefronts of linear polarization waves. Four arrangements of 5 x 5 CSRRs are fabricated to validate the design methodology of beam steering based on the designed two distributions and the two control methods. Furthermore, two reconfigurable Fabry-Perot (FP) antennas are proposed based on liquid-metal and mechanically rotating reconfiguration, demonstrating higher aperture efficiency, desirable radiation patterns, and excellent reconfiguration reliability. Moreover, an eight-element phased array combined with a liquid-metal PRS is fabricated and shows improved scanning performance and stable gain fluctuation.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Letter
Biophysics
Fei Zhou, Tingting Pan, Xiaoli Li, Feng Du, Xiao Ma, Yanming Zhang, Depei Wu, Yue Han, Shengli Xue, Miao Miao, Tao Tao, Xuefeng He, Suning Chen
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
James M. Foran, Zhuoxin Sun, Catherine Lai, Hugo F. Fernandez, Larry D. Cripe, Rhett P. Ketterling, Janis Racevskis, Selina M. Luger, Elisabeth Paietta, Hillard M. Lazarus, Yanming Zhang, John M. Bennett, Ross L. Levine, Jacob M. Rowe, Mark R. Litzow, Martin S. Tallman
Summary: This study examined the association of obesity with AML and its impact on clinical outcomes. The results showed that obesity was associated with certain clinical and genetic features of AML, but did not affect patient survival.
Article
Immunology
Qiong Wu, Yanjun Wu, Ye Zhao, Yanming Zhang, Junjie Cao, Depei Wu, Juying Zhou, Feng Chen
Summary: This study aims to observe and analyze the clinical characteristics and prognosis of adenovirus (ADV) infection diagnosed by metagenomic next-generation sequencing (mNGS) after haploidentical hematopoietic stem cell transplantation (Haplo-HSCT). The results showed that mNGS can provide screening for ADV and information on ADV subtypes, helpful for diagnosing patients at high risk for ADV infection. ADV infection can involve multiple organs, has difficulty in early diagnosis, and has a poor prognosis. Currently, effective treatments are inadequate.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Microbiology
Liang Zhang, Yanyan Yi, Tao Wang, Mengzhao Song, Kangkang Guo, Yanming Zhang
Summary: Classical swine fever virus (CSFV) utilizes cellular lipids and manipulates host lipid metabolism to ensure its replication. In this study, we screened the anti-CSFV activity of 12 compounds targeting lipid metabolism pathways. 25-hydroxycholesterol (25HC) exhibited potent anti-CSFV activity by inhibiting virus entry into cells.
VETERINARY MICROBIOLOGY
(2023)
Letter
Oncology
Zhenzhen Yao, Bin Gu, Jia Chen, Yang Xu, Feng Chen, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Lei Yu, Yanming Zhang, Depei Wu, Ying Wang
BLOOD CANCER JOURNAL
(2023)
Article
Anesthesiology
Juan Zhi, Xiao-Ming Deng, Yan-Ming Zhang, Ling-Xin Wei, Qian-Yu Wang, Dong Yang
Summary: This study evaluated the application of the novel SaCoVLM video laryngeal mask-guided intubation in anesthetized children. The results showed a high first-pass success rate and suggested that this technique can be a promising device for airway management in pediatric patients.
BMC ANESTHESIOLOGY
(2023)
Article
Business, Finance
Minhao Gu, Yanming Zhang, Dan Li, Baofeng Huo
Summary: This study explores the impact of high-involvement human resource management practices on supply chain resilience and the relationship between the dimensions of supply chain resilience and operational performance. The findings suggest that employee participation plays a crucial role in improving supplier, customer, and internal resilience. However, employee skills only facilitate internal and customer resilience, while employee incentives do not influence supply chain resilience. Additionally, internal and customer resilience have positive effects on operational performance, but supplier resilience does not significantly affect it. These findings contribute to both academia and practice.
JOURNAL OF MANAGEMENT SCIENCE AND ENGINEERING
(2023)
Correction
Oncology
Franck Rapaport, Kenneth Seier, Yaseswini Neelamraju, Duane Hassane, Timour Baslan, Daniel T. Gildea, Samuel Haddox, Tak Lee, H. Moses Murdock, Caroline Sheridan, Alexis Thurmond, Ling Wang, Martin Carroll, Larry D. Cripe, Hugo Fernandez, Christopher E. Mason, Elisabeth Paietta, Gail J. Roboz, Zhuoxin Sun, Martin S. Tallman, Yanming Zhang, Mithat Gonen, Ross Levine, Ari M. Melnick, Maria Kleppe, Francine E. Garrett-Bakelman
BLOOD CANCER JOURNAL
(2023)
Meeting Abstract
Medicine, Research & Experimental
Dianne Torrence, Josephine Dermawan, Yanming Zhang, Chad Vanderbilt, Kerry Mullaney, Achim Jungbluth, Purvil Sukhadia, Narasimhan Agaram, Meera Hameed
LABORATORY INVESTIGATION
(2023)