Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 6, Pages 2119-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja809069b
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Funding
- Harvard Origins Initiative
- NSF [CHE 0434507]
- Howard Hughes Medical Institute
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [809413] Funding Source: National Science Foundation
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Glycerol nucleic acid (GNA) is an interesting base-pairing system with an acyclic, three-carbon backbone. In the present study, GNA analogues with N2'-> P3' phosphoramidate linkages (npGNA) have been synthesized and their base-pairing properties examined. Thermal denaturation and circular dichroism studies show that npGNA can form stable duplexes with itself and with GNA. Furthermore, we show that npGNA can be assembled by template-directed ligation of 3'-imidazole-activated-2'-amino GNA dinucleotides. These results suggest that npGNA is a potential candidate for a self-replicating system based upon phosphoramidate linkages.
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