Article
Chemistry, Organic
Zhichao Wang, Shoko Yamazaki, Yuji Mikata, Miho Oba, Hiroshi Takashima, Tsumoru Morimoto, Akiya Ogawa
Summary: Intramolecular cycloaddition reactions of α-bromostyr-ene-functionalized amides have been investigated, resulting in the formation of 1,4-dihydronaphthalenes and naphthalene derivatives under suitable reaction conditions. The mechanisms of these reactions may involve the intervention of molecular oxygen and subsequent radical reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Doris Chen, Elizabeth Jones, Corey W. Williams, Tan-Khang N. Huynh, Tristan C. McPhail, Stefan France
Summary: In this study, a SnCl4-catalyzed intramolecular, interrupted homo-Nazarov cascade biscyclization method was developed to access angular (hetero)aryl-fused polycycles. The cyclopropyl homo-Nazarov cyclization precursors were formed using a scalable and modular synthetic route, enabling the synthesis of various angular polycyclic products. The method was successfully applied in the total synthesis of (+/-)-1-oxoferruginol, an antibacterial aromatic abietane diterpenoid.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
O. Palumbo, F. Trequattrini, A. Cimini, A. Tsurumaki, M. A. Navarra, A. Paolone
Summary: The study investigates the intra- and intermolecular interactions in ether-functionalized ionic liquids through infrared spectroscopy measurements, finding that the trans conformer of the FSI anion is more stable than the cis conformer and there is evidence of hydrogen bonding between the anion's O atom and the closest H atoms on the cation. The results suggest that such highly directional interactions are more observable in ether-functionalized samples, particularly those containing FSI as an anion.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Inorganic & Nuclear
Zhao Zhao, Jingjie Tan, Ting Chen, Zahid Hussain, Yanguo Li, Yile Wu, Douglas W. Stephan
Summary: This study investigates the reactions of germylene chloride and germylene thiocyanate with phenylacetylene and B(C6F5)3, leading to the formation of different products due to the difference in their reactant structures. The results provide insights into the reactivity and bonding of these compounds.
INORGANIC CHEMISTRY
(2022)
Editorial Material
Chemistry, Organic
Erick M. Carreira, Pauline Chiu
Review
Food Science & Technology
Yi Wang, Yau-Yan Lim, Zhendan He, Wing-Tak Wong, Wing-Fu Lai
Summary: Recent research has shown a growing interest in the relationship between dietary phytochemicals, the gut microbiota, and Alzheimer's disease. However, little discussion has been made about the detailed connections between these factors and how phytochemicals modulate gut dysbiosis induced pathologies of Alzheimer's disease. Deciphering these connections could provide insights for the development of dietary phytochemicals as anti-Alzheimer drug candidates.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Wing-Fu Lai, Wing-Tak Wong
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Medical Informatics
Tao Zhong, Zian Zhuang, Xiaoli Dong, Ka Hing Wong, Wing Tak Wong, Jian Wang, Daihai He, Shengyuan Liu
Summary: This study developed an interpretable prediction model based on the XGBoost algorithm to predict the risk of TB-DILI in patients using clinical data. The model selected recent alanine transaminase levels, rate of change of alanine transaminase levels, cumulative dose of pyrazinamide, and cumulative dose of ethambutol as the best predictors. Validation results showed high precision, recall, and classification accuracy, with a warning of high risk provided to patients on average 15 days before DILI onset.
JMIR MEDICAL INFORMATICS
(2021)
Correction
Medical Informatics
Tao Zhong, Zian Zhuang, Xiaoli Dong, Ka Hing Wong, Wing Tak Wong, Jian Wang, Daihai He, Shengyuan Liu
JMIR MEDICAL INFORMATICS
(2021)
Article
Chemistry, Multidisciplinary
King-Him Yim, Chi-Tung Yeung, Michael R. Probert, Wesley Ting Kwok Chan, Lewis E. Mackenzie, Robert Pal, Wing-Tak Wong, Ga-Lai Law
Summary: The study investigates the impact of ionic radii and linker length on the formation of lanthanide supramolecular complexes, revealing that the supramolecular transformation is governed by both the ionic radii as well as the ligand design. Controlled formation of helicates or tetrahedron shaped cages is achieved by adjusting the interplay between the metal ionic radius and the ligand composition.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Pathology
Hin Fung Tsang, Allen Chi Shing Yu, Heong Ting Wong, Wai Ming Stanley Leung, Jiachi Chiou, Yin Kwan Evelyn Wong, Aldrin Kay Yuen Yim, Dominic Ngai Chong Tsang, Alan K. L. Tsang, Wing Tak Wong, Sze Chuen Cesar Wong, William Chi Shing Cho
Summary: A study analyzed 14 SARS-CoV-2 genome sequences collected in Hong Kong from July 2020 to March 2021, identifying 9 strains belonging to the B.1.36.27 lineage. Compared to the reference genome, this strain showed 31 nucleotide differences and 11 amino acid differences. The study found no evidence to suggest that SARS-CoV-2 from the B.1.36.27 lineage can impact existing vaccines and antibody therapies.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Chemistry, Organic
Siyuan Guo, Kong Ching Wong, Stephan Scheeff, Zhuo He, Wesley Ting Kwok Chan, Kam-Hung Low, Pauline Chiu
Summary: The copper-catalyzed reductive Ireland-Claisen rearrangement led to the synthesis of diastereomeric products with divergent selectivity, utilizing silanes or pinacolborane as reducing agents and triethylphosphite as a ligand. The mechanism studies showed that silyl and boron enolates underwent a stereospecific rearrangement via a chairlike transition state to afford the Claisen rearrangement products.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yueyao Chen, Jesse Ling, Angus B. Keto, Yun He, Kam-Hung Low, Elizabeth H. Krenske, Pauline Chiu
Summary: Epoxy and aziridinyl enolsilanes can react as oxyallylic cation equivalents in highly selective and stereoselective intramolecular (3+2) cycloadditions. Computational studies suggest that the stepwise reaction involves the conformational flexibility of the intermediate, which determines the formation of (3+2) cycloadducts. This method can be used for the synthesis of densely functionalized trans-hydrindane scaffolds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Medicinal
Wing-Fu Lai, Obireddy Sreekanth Reddy, Haotian Zhang, Dahong Zhang, Wing-Tak Wong
Summary: This article reviews the current status and applications of graphene-based sensors in pharmaceutical analysis, providing insights into future engineering and optimization of these sensors. It offers a snapshot of recent advances in the fabrication and use of graphene-based sensors.
Article
Food Science & Technology
Xin Liu, Zhong Rui Du, Xiong Wang, Xiang Rong Sun, Qing Zhao, Fang Zhao, Wing Tak Wong, Ka Hing Wong, Xiao-Li Dong
Summary: This study discovered that the combination of polymannuronic acid (PM) and Lacticaseibacillus rhamnosus GG (LGG) provided neuroprotection in a chronic Parkinson's disease (PD) mice model. PM exerted neuroprotection through a short chain fatty acids (SCFAs)-mediated anti-inflammation and anti-apoptosis mechanism, while LGG may improve the expression of striatal glial cell-derived neurotrophic factor (GDNF) and increase the abundance of Clostridiales bacteria. The combination of PM and LGG showed better neuroprotective effects than using PM or LGG alone.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Wing-Fu Lai, Wing-Tak Wong
Summary: This study compares the performance of edible starch films from different botanical sources in food packaging and finds that the source of starch significantly affects the water vapor permeability, maximum tensile strength, and elongation at break. The study also discovers that the clusteroluminescence of starch can serve as an indicator for the state of packaged frozen food.
Article
Nanoscience & Nanotechnology
Shiying Li, Kwok-Ho Lui, Wing-Sum Lau, Juyu Chen, Wai-Sum Lo, Xin Li, Yan-Juan Gu, Liang-ting Lin, Wing-Tak Wong
Summary: A novel multifunctional nanotheranostic agent PAuE has been developed for multispectral optoacoustic tomography-guided photo-thermal therapy and chemotherapy, showing remarkable tumor growth inhibition in mouse models and providing a new insight into anti-cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Wing-Fu Lai, Wing-Tak Wong
Summary: This article reviews the principles of designing polymeric active packaging films, discusses factors to be considered during materials selection and film generation, and explores practical considerations for the use of these films in active food packaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Wing-Fu Lai, Ryan Deng, Tingchao He, Wing-Tak Wong
Summary: Biofluorescence and cellular responses to internal physiological signals are incorporated into the design of a bioinspired material called CPS. CPS demonstrates clusterization-triggered emission and shows promising results in tissue repair, with the ability for biphasic chemical sensing.
ADVANCED HEALTHCARE MATERIALS
(2021)
