Article
Biochemistry & Molecular Biology
Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Takahiko Shimizu
Summary: The study showed that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis, but did not affect ROS-mediated tissue degeneration in SOD-deficient models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Edurne Tellechea, Aaron C. Asensio, Paula Ciaurriz, Javier Buezo, Pedro Lopez-Gomez, Marina Urra, Jose F. Moran
Summary: This study investigates the characteristics of the recombinant cowpea FeSOD immobilized onto gold nanoparticles (AuNPs) and the effects of NP surface chemistry and biofunctionalization methods on enzyme activity. The results highlight the importance of the biomolecule and AuNP interaction for the functionality of the hybrid and demonstrate the potential of these strategies in biomedical applications.
Article
Biochemistry & Molecular Biology
Cecilie L. Matthiesen, Lili Hu, Astrid S. Torslev, Ebbe T. Poulsen, Ulrike G. Larsen, Kasper Kjaer-Sorensen, Jesper S. Thomsen, Annemarie Bruel, Jan J. Enghild, Claus Oxvig, Steen V. Petersen
Summary: The study revealed that SOD3 plays an unappreciated role in bone development and homeostasis, with Sod3b showing specific expression in skeletal tissue in zebrafish.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Physical
Muqing Ren, Jinhang Chen, Gang Wu, Emily A. McHugh, Ah-Lim Tsai, James M. Tour
Summary: The formation of LiO2 in Li-O-2 and Li-air batteries triggers irreversible reactions and low Coulombic efficiency.
Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Plant Sciences
Giovanna Salbitani, Angela Perrone, Luigi Rosati, Carmen Laezza, Simona Carfagna
Summary: This study investigates the effects of sulfur deprivation on Galdieria sulphuraria and reveals that it leads to a decrease in total protein content and an increase in soluble protein fraction. The glutathione content in Galdieria sulphuraria remains high even under sulfur deprivation.
Article
Nanoscience & Nanotechnology
Jonghak Kim, Jeongin Lee, Jinhyeon Jeong, Chihyun Hwang, Hyun-Kon Song
Summary: Quinones with a fully conjugated cyclic dione structure have been used as redox mediators in electrochemistry. Tuning the isomeric configuration of the carbonyl groups of the substituted quinone can change its reduction potentials and facilitate superoxide disproportionation reactions, improving the cycling durability of lithium-oxygen batteries. The ortho isomer of 2,5-Ditert-butyl-1,4-benzoquinone shows electrocatalytic functionality for promoting superoxide disproportionation reaction and oxygen reduction reaction in lithium-oxygen batteries.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biology
ShylajaNaciyar Mohandass, Mangalalakshmi Ragavan, Dineshbabu Gnanasekaran, Uma Lakshmanan, Prabaharan Dharmar, Sushanta Kumar Saha
Summary: Synthetic azo dyes are widely used but their improper discharge poses a threat to the environment. Genetically modified cyanobacteria with enhanced H2O2 accumulation through SOD overexpression can effectively degrade these dyes, suggesting a valuable bioremediation strategy.
Article
Fisheries
Min Yang, Luchuanyang Sun, Yasunosuke Kawabata, Takahiro Maegawa, Shigeto Taniyama, Katsuyasu Tachibana, Katsuya Hirasaka
Summary: Balenine, an endogenous imidazole dipeptide composed of beta-alanine and 3-methyl-l-histidine, is found mainly in muscles and the brain. Studies have shown that balenine exhibits antioxidant activity by increasing SOD activity without affecting other antioxidant enzymes. This suggests that balenine contributes to antioxidant effects through activation of SOD.
Article
Forestry
Ya Chen, Hua Wu, Zhaodong Hao, Liming Zhu, Lu Lu, Jisen Shi, Jinhui Chen
Summary: This study systematically identified and analyzed the SOD gene family of woody plant Liriodendron chinense, and investigated the transcriptional responses of LcSOD genes to abiotic stresses. A total of eight SOD genes were identified and divided into two subgroups. The gene expression analysis revealed the response of LcSOD genes to abiotic stresses, providing potential targets for improving stress tolerance in L. chinense.
Article
Plant Sciences
Chunsong Huo, Linshen He, Ting Yu, Xue Ji, Rui Li, Shunqin Zhu, Fangyuan Zhang, He Xie, Wanhong Liu
Summary: This study systematically characterized the SOD gene family in the tobacco genome, identifying 15 NtSOD genes classified into three subgroups. Functional predictions were consistent with subcellular localization, indicating a protective role against ROS induced by heavy metal stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Physical
Jonghak Kim, Gwan Yeong Jung, Chihyun Hwang, Jinhyeon Jeong, Kyungeun Baek, Jeongin Lee, Seok Ju Kang, Sang Kyu Kwak, Hyun-Kon Song
Summary: TEMPO-COOH acts as a bifunctional mobile catalyst to improve the performance of aprotic lithium-oxygen batteries by reducing side reactions during discharge and decreasing overpotential during charge, leading to a significant increase in cycle life and discharge capacity.
JOURNAL OF POWER SOURCES
(2021)
Article
Cell Biology
Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab, Yasamin Hosseini, Amirhossein Niknejad, Saeideh Momtaz, Amir Hossein Abdolghaffari, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Prashant Kesharwani, Amirhossein Sahebkar
Summary: In recent years, the prevalence of neurodegenerative diseases (NDD) has significantly increased, placing a burden on the community health system due to high healthcare costs. Superoxide dismutase (SOD) is a metalloenzyme that protects the body from oxidative stress through antioxidants. SOD supplementation can activate the body's natural antioxidant mechanism and neutralize excessive free radicals. Excessive reactive oxygen species (ROS) and reactive nitrogen species (RNS) can damage DNA and RNA, leading to mitochondrial dysfunction and oxidative stress-related diseases like NDD. Curcumin (Cur) has been shown to possess anti-inflammatory and neuroprotective properties, making it a potential therapeutic agent for NDD, possibly through its interaction with SOD.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Agricultural Engineering
Bhawana Mishra, Muktesh Chandra, Deepak Pant
Summary: The study evaluated the genetic, antioxidant compound, and metabolite activities of medicinal and aromatic plants with phytoremediation potential. The research demonstrated that these plants possess characteristics related to antioxidants, phytoremediation, and stress tolerance.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Biochemistry & Molecular Biology
Vyshnavy Balendra, Sandeep Kumar Singh
Summary: Oxidative stress leads to neurotoxic protein accumulation in AD, while antioxidants like SOD and AST can prevent cognitive decline and reduce plaque burden in mice.
Article
Biochemistry & Molecular Biology
Nicholas E. Buglak, Wulin Jiang, Edward S. M. Bahnson
Article
Engineering, Biomedical
Erica B. Peters, Nick D. Tsihlis, Mark R. Karver, Stacey M. Chin, Bruno Musetti, Benjamin T. Ledford, Edward M. Bahnson, Samuel I. Stupp, Melina R. Kibbe
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Cardiac & Cardiovascular Systems
Nicholas E. Buglak, Jennifer Lucitti, Pablo Ariel, Sophie Maiocchi, Francis J. Miller, Edward S. M. Bahnson
Summary: The study highlights the importance of evaluating preclinical models of vascular disease for successful translation of novel treatments. The use of light sheet fluorescence microscopy (LSFM) allows for more precise measurements compared to traditional histological methods, providing a novel and robust 3D imaging platform for visualizing and quantifying arterial injury. LSFM outperforms classic histology in precision and quantitative capabilities while minimizing user bias associated with 2D histological analysis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Feng Li, Edward M. Bahnson, Jennifer Wilder, Robin Siletzky, John Hagaman, Volker Nickekeit, Sylvia Hiller, Azraa Ayesha, Lanfei Feng, Jerrold S. Levine, Nobuyuki Takahashi, Nobuyo Maeda-Smithies
Article
Multidisciplinary Sciences
Nicholas E. Buglak, Edward S. M. Bahnson
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Pharmacology & Pharmacy
Hussein A. Kassam, Edward M. Bahnson, Ana Cartaya, Wulin Jiang, Michael J. Avram, Nick D. Tsihlis, Samuel I. Stupp, Melina R. Kibbe
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2020)
Article
Surgery
Monica M. Grova, Sean J. Donohue, Matthew Bahnson, Michael O. Meyers, Edward M. Bahnson
Summary: The study assessed LGBTQ+ allyship in surgical residents and found that training improved their knowledge and skills, as well as increased their openness and support for LGBTQ+ patients. The training was perceived as relevant to surgical patient care by the majority of participants, and was found to enhance their competency in caring for LGBTQ+ patients.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ana E. Cartaya, Halle Lutz, Sophie Maiocchi, Morgan Nalesnik, Edward M. Bahnson
Summary: The nanoformulation ARAPas allows selective delivery of Nrf2 activator CA to injured vasculature, effectively inhibiting VSMC proliferation and migration while activating Nrf2. Encapsulation of CA in pluronic micelles enables efficient uptake by macrophages and subsequent transfer to VSMC, highlighting the potential for targeted delivery in vascular interventions.
Article
Immunology
Jenna E. Beam, Nikki J. Wagner, John C. Shook, Edward S. M. Bahnson, Vance G. Fowler, Sarah E. Rowe, Brian P. Conlon
Summary: Staphylococcus aureus is a common human pathogen that often leads to chronic infections, with persister cells contributing to the failure of antibiotic treatment; host-derived peroxynitrite is identified as a major mediator of antibiotic tolerance in macrophages infected by S. aureus; these findings highlight the significant impact of host-bacterial interactions on antibiotic tolerance and suggest that modulating the host response could be a potential therapeutic strategy to enhance S. aureus sensitivity to antibiotics.
INFECTION AND IMMUNITY
(2021)
Article
Materials Science, Biomaterials
Sophie Maiocchi, Ana Cartaya, Sydney Thai, Adam Akerman, Edward Bahnson
Summary: Atherosclerotic disease, driven by redox dysfunction, is a leading cause of death worldwide. However, the translation of redox-based therapies to clinical applications remains challenging. In this study, researchers developed Antioxidant Response Activating nanoparticles (ARAPas) that target the dysfunctional endothelium and selectively accumulate in atherosclerotic plaque. These nanoparticles encapsulate a redox-active drug and have anti-inflammatory and anti-oxidative effects. The results demonstrate the selective accumulation of these nanoparticles in atherosclerotic plaque and the activation of Nrf2-target genes.
BIOMATERIALS SCIENCE
(2022)
Article
Microbiology
Jenna E. Beam, Sophie Maiocchi, Ana Cartaya, Sarah E. Rowe, Edward S. M. Bahnson, Brian P. Conlon
Summary: Interactions between Staphylococcus aureus and the host immune system can significantly affect antibiotic efficacy. Modulating the immune response may improve antibiotic efficacy and infection outcome.
MICROBIOLOGY SPECTRUM
(2022)
Article
Cell Biology
Roberto Mota, Samuel E. Morgan, Edward M. Bahnson
CURRENT PATHOBIOLOGY REPORTS
(2020)
Article
Cell Biology
Ana Cartaya, Sophie Maiocchi, Edward M. Bahnson
CURRENT PATHOBIOLOGY REPORTS
(2019)
Article
Medicine, Research & Experimental
Masao Kakoki, Edward M. Bahnson, John R. Hagaman, Robin M. Siletzky, Ruriko Grant, Yukako Kayashima, Feng Li, Esther Y. Lee, Michelle T. Sun, Joan M. Taylor, Jessica C. Rice, Michael F. Almeida, Ben A. Bahr, J. Charles Jennette, Oliver Smithies, Nobuyo Maeda-Smithies
Article
Pharmacology & Pharmacy
Bruno Musetti, Helena Gonzalez-Ramos, Mercedes Gonzalez, Edward M. Bahnson, Javier Varela, Leonor Thomson
JOURNAL OF CANNABIS RESEARCH
(2020)
