Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 40, Pages 13190-13191Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja804607v
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Funding
- NSF [MCB 0451448]
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A new type of double-stranded DNA targeting format by formation of a Janus-Wedge (J-W) triple helix is described. The wedge residue W-1 is used for A-T and T-A base pairs while W-2 is used for G-C and C-G base pairs. Both wedge residues are attached to a PNA backbone that is designed to insert the probe strand into double-stranded DNA and base pair with bothe Watson-Crick faces. To study the stability of such an assembly, we have examined the formation of the J-W triplex with various sequences.
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