4.8 Article

Catalytic Enantioselective Intermolecular Hydroacylation: Rhodium-Catalyzed Combination of β-S-Aldehydes and 1,3-Disubstituted Allenes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 51, Pages 17232-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja8069133

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Funding

  1. EPSRC
  2. AstraZeneca
  3. Engineering and Physical Sciences Research Council [EP/C011082/1] Funding Source: researchfish
  4. EPSRC [EP/C011082/1] Funding Source: UKRI

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A rhodium(I) catalyst incorporating the Me-DuPhos ligand promotes enantioselective intermolecular hydroacylation between P-S-aldehydes and 1,3-disubstituted allenes. The nonconjugated enone products are obtained in good yields and with high enantioselectivities.

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