Journal
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
Volume 96, Issue 3, Pages 928-934Publisher
WILEY-BLACKWELL
DOI: 10.1111/jace.12059
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Funding
- Recruitment Program of Global Young Talent, China
- Natural Science Foundation of China [81201202, 81190132]
- Shanghai Municipal Natural Science Foundation [12ZR1435300]
- ARC Discovery [DP120103697]
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The aim of this study is to prepare Ca, P and Si-containing ternary oxide nagelschmidtite (NAGEL, Ca7Si2P2O16) bioceramics and explore their in vitro bioactivity for potential bone tissue regeneration. We prepared dense NAGEL ceramics through high-temperature sintering of NAGEL ceramic powders. The apatite-mineralization ability, dissolution rate, and human osteoblast response (including cytotoxicity analysis, attachment, morphology, proliferation, and bone-related gene expression) to NAGEL ceramics have been systematically studied by comparing with conventional -tricalcium phosphate (-TCP) ceramics. The results showed that NAGEL ceramics possessed more obvious apatite mineralization and dissolution (degradation) and stimulated bone-related gene expression (OCN and OPN) of osteoblasts than -TCP ceramics. NAGEL ceramics also showed no significant cytotoxicity. NAGEL ceramics supported osteoblast attachment, proliferation, and osteogenic gene expression, with a comparable cell proliferation activity with -TCP ceramics. These results indicate that novel NAGEL bioceramics with the specific composition of Ca7Si2P2O16, are a promising biomaterial for bone tissue regeneration application.
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