Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington’s Disease (HD) and Spinocerebellar Ataxias (SCAs)

Expression of Expanded CAG Transcripts Triggers Nucleolar Stress in Huntington's Disease

(2013) Ho Tsoi et al.   CEREBELLUM

Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts

(2013) Matthew D. Disney   DRUG DISCOVERY TODAY

RNA toxicity in polyglutamine disorders: concepts, models, and progress of research

(2013) Agnieszka Fiszer et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Dynamic Structural Model of Expanded RNA CAG Repeats: A Refined X-ray Structure and Computational Investigations Using Molecular Dynamics and Umbrella Sampling Simulations

(2013) Ilyas Yildirim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Correction of Pre-mRNA Splicing Defects Associated with Sequestration of Muscleblind-like 1 Protein by Expanded r(CAG)-Containing Transcripts

(2012) Amit Kumar et al.   ACS Chemical Biology

CAG expansion induces nucleolar stress in polyglutamine diseases

(2012) H. Tsoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations

(2011) Amit Kumar et al.   BIOCHEMISTRY

NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1

(2011) Raman Parkesh et al.   BIOCHEMISTRY

A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome

(2011) Amit Kumar et al.   CHEMBIOCHEM

Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs

(2011) Clare L. van Eyk et al.   HUMAN MOLECULAR GENETICS

Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats

(2011) Agnieszka Fiszer et al.   NUCLEIC ACIDS RESEARCH

CAG repeats mimic CUG repeats in the misregulation of alternative splicing

(2011) Agnieszka Mykowska et al.   NUCLEIC ACIDS RESEARCH

Structural Diversity of Triplet Repeat RNAs

(2010) Krzysztof Sobczak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A′-form RNA helices are required for cytoplasmic mRNA transport in Drosophila

(2010) Simon L Bullock et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PolyQ Disease: Too Many Qs, Too Much Function?

(2010) Ian H. Kratter et al.   NEURON

Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases

(2010) Agnieszka Kiliszek et al.   NUCLEIC ACIDS RESEARCH

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structural insights into CUG repeats containing the ‘stretched U–U wobble’: implications for myotonic dystrophy

(2009) Agnieszka Kiliszek et al.   NUCLEIC ACIDS RESEARCH

Targeting RNA with Small Molecules

(2008) Jason R. Thomas et al.   CHEMICAL REVIEWS

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

(2008) Ling-Bo Li et al.   NATURE