Article
Veterinary Sciences
Yuxin Yang, Jingyuan Kong, Yu Liu, Qinyao Wu, Yuying Cao, Jicheng Qiu, Lu Zhang, Xiaohui Gong, Fuhua Zhao, Xingyuan Cao, Jianzhong Wang
Summary: This study investigated the pharmacokinetic profiles and bioequivalence of two cyclosporine oral solutions in cats. The results showed no significant differences in major pharmacokinetic parameters between the two formulations and the blood profiles of cyclosporine were similar after administration.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Jamie G. Anderson, Connie A. Rojas, Elisa Scarsella, Zhandra Entrolezo, Guillaume Jospin, Sharon L. Hoffman, Judy Force, Roxane H. Maclellan, Mike Peak, Bonnie H. Shope, Anson J. Tsugawa, Holly H. Ganz
Summary: This study used 16S rRNA gene sequencing to analyze the oral microbiome in cats with feline chronic gingivostomatitis (FCGS), healthy cats, and cats with other oral conditions. The results showed that the microbiomes of cats with FCGS were different from those of healthy cats, indicating dysbiosis throughout the oral cavity. The study also found that different oral conditions have varying effects on the microbiome. Additionally, the microbiome data obtained from oral swabs were comparable to those obtained from plaque samples. These findings contribute to a better understanding of FCGS and have implications for the prevention, diagnosis, and treatment of this condition.
Article
Veterinary Sciences
Jingyuan Kong, Yuxin Yang, Yu Liu, Jicheng Qiu, Yuying Cao, Xingyuan Cao, Pan Sun
Summary: This study aimed to evaluate the absolute bioavailability of cyclosporine in cats by comparing the pharmacokinetic profiles of oral and intravenous administration. The results showed that the medium dose of cyclosporine had great potential to be absorbed in the body. Monitoring the concentration of cyclosporine is necessary to prevent side effects in clinical use. Taking a blood sample 4 hours after oral administration is recommended for better estimation of absorption extent and prevention of side effects. Rating: 7/10.
VETERINARY SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Alessandra T. Zizzari, Dimanthi Pliatsika, Flavio M. Gall, Thomas Fischer, Rainer Riedl
Summary: Peptides, due to their structural diversity, are considered a unique source of innovative active ingredients, but face challenges in development due to their disadvantageous pharmacokinetic properties. Recent efforts have focused on improving the oral bioavailability of peptide drugs, with the latest findings expected to influence future approaches in developing more efficient and safer orally delivered peptides by pharmaceutical companies.
DRUG DISCOVERY TODAY
(2021)
Article
Veterinary Sciences
Tom Jukier, Crisanta Cruz-Espindola, Doug Martin, Dawn M. Boothe
Summary: The historical use of marijuana for medicinal purposes includes its use in the treatment of epilepsy. Recently, a highly purified cannabidiol medication has been approved by the FDA for add-on therapy in certain forms of epilepsy. This study focused on determining the disposition of a single dose of cannabidiol in healthy cats, both in fed and fasted states. The pharmacokinetic analysis showed that cannabidiol has a significantly higher bioavailability when administered in a fed state compared to a fasted state, indicating its potential therapeutic value for epilepsy in cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Dennis J. Woerde, Luke A. Wittenburg, Jonathan D. Dear
Summary: This study investigated the pharmacokinetics of isavuconazole in cats and found that both IV and PO administration resulted in high serum concentrations. The results suggest that isavuconazole can be useful in treating fungal infections in cats, but further studies are required to assess its safety, efficacy, and tolerability.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Chemistry, Analytical
Maja Brloznik, Ema Lunka, Viktor Avbelj, Alenka Nemec Svete, Aleksandra Domanjko Petric
Summary: This pilot study investigated the electromechanical activity of the heart in healthy cats and cats with cardiomyopathy using a phonocardiography (PCG) device synchronized with electrocardiography (ECG). The results showed that cats with cardiomyopathy had longer electromechanical activation time (EMAT), electrical and mechanical systole duration compared to healthy cats, suggesting impaired heart function.
Article
Agriculture, Dairy & Animal Science
Nina Hoeyrup, Thomas Spillmann, Linda Toresson
Summary: Cyclosporine is suggested as an immunosuppressive treatment for cats with chronic pancreatitis (CP). This study found that cyclosporine treatment significantly reduces serum Spec fPL concentrations, indicating an improvement in pancreatic inflammation.
Article
Veterinary Sciences
Jennifer E. Slovak, Ana P. Costa
Summary: The study found that gabapentin can permeate feline skin and be systemically absorbed, potentially helping to reduce pain scores.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Halley Gora Ravuri, Nana Satake, Alexandra Balmanno, Jazmine Skinner, Samantha Kempster, Paul C. Mills
Summary: This study evaluated the pharmacokinetic parameters of ketoprofen after intravenous and transdermal administration in healthy dogs. The results showed that transdermal administration of ketoprofen in dogs had a longer elimination half-life, higher AUC, and longer residence time compared to intravenous administration. It took 30 minutes to reach effective plasma concentrations after transdermal application.
Article
Multidisciplinary Sciences
Marta Godia, Louise Brogaard, Emilio Marmol-Sanchez, Rebecca Langhorn, Ida Nordang Kieler, Bert Jan Reezigt, Lise Nikolic Nielsen, Lisbeth Rem Jessen, Susanna Cirera
Summary: This study characterized the miRNAome in cat urine for the first time and found that urinary miRNA profiles could potentially serve as non-invasive biomarkers for diagnosing feline pyelonephritis and other urological conditions.
Article
Agriculture, Dairy & Animal Science
Keisuke Sugimoto, Kazutoshi Sugita, Kensuke Orito, Yoko Fujii
Summary: This study investigated the pharmacodynamics of repeated and multiple-dose pimobendan in healthy cats. The results showed that repeated doses of pimobendan increased cardiac systolic function and there were significant correlations between cardiac function and plasma concentrations of pimobendan and ODMP. These findings highlight the effectiveness of a higher dose of pimobendan.
Review
Biochemistry & Molecular Biology
Ayala Bar-Hai, Abraham J. Domb, Amnon Hoffman
Summary: Oral administration of cannabinoids is a convenient route of administration. Lipid-based formulations can be used to enhance the solubility issue and achieve enhanced oral bioavailability of cannabinoids by selecting appropriate strategies.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Infectious Diseases
Kate Van Brussel, Xiuwan Wang, Mang Shi, Maura Carrai, Shuo Feng, Jun Li, Edward C. Holmes, Julia A. Beatty, Vanessa R. Barrs
Summary: This study characterized the enteric virome in cats infected with feline panleukopenia virus (FPV) and compared it with healthy cats. The results showed that feline coronavirus, feline bocavirus, and feline calicivirus were more commonly present in cats with FPV, and feline bocavirus 2 was detected at a higher frequency in FPV cases compared to healthy controls. The differences in virome composition may be associated with the severity of clinical disease in cats with FPV.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Veterinary Sciences
Susan Gottlieb, Jacquie S. Rand, Katsumi Ishioka, Daniel A. Dias, Berin A. Boughton, Ute Roessner, Ziad Ramadan, Stephen T. Anderson
Summary: This study compared insulin, adiponectin, leptin, and measures of insulin sensitivity between diabetic cats in remission and healthy control cats, and investigated their associations with serum metabolites. The results showed that insulin resistance persists in diabetic remission cats, indicating the importance of managing insulin resistance in cats in remission.
FRONTIERS IN VETERINARY SCIENCE
(2022)