Article
Dermatology
Bin Wang, Songlin Li, Jinkang Zhang, Di Wu, Xiaogang Huang, Dongzhou Liu, Junjie Du
Summary: This meta-analysis research evaluated the effectiveness of intrawound vancomycin powder (IWVP) as a prophylactic measure against surgical site wound infections (SSWIs) in orthopaedic surgery (OPS). The findings indicated that IWVP resulted in significantly lower rates of SSWIs, deep SSWIs, and superficial SSWIs compared to control. However, caution should be exercised when interpreting the results, and further research is required to confirm these findings.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cell & Tissue Engineering
M. M. Welling, K. Warbroek, C. Khurshid, M. N. van Oosterom, D. D. D. Rietbergen, M. G. J. de Boer, R. G. H. H. Nelissen, F. W. B. van Leeuwen, B. G. Pijls, T. Buckle
Summary: In this study, the ability of a bacteria-specific hybrid tracer (99mTc-UBI29-41-Cy5) to visualize the bacterial load on femoral implants using clinical-grade image guidance methods was evaluated. The results showed that this hybrid tracer allowed effective bacterial staining and combined qualitative real-time fluorescence guidance with nuclear imaging for quantitative monitoring of the effectiveness of cleaning strategies.
BONE & JOINT RESEARCH
(2023)
Article
Orthopedics
Felix Rohrer, Anita Maurer, Hubert Noetzli, Brigitta Gahl, Andreas Limacher, Tanja Hermann, Jan Bruegger
Summary: The use of prolonged surgical antibiotic prophylaxis (PSAP) in orthopaedic surgery, despite guidelines advising against it, was found to be 12% in this study. Patient-related factors associated with PSAP use included older age, higher BMI, ASA classification >= 3, and lung disease, while surgery-related factors included use of prosthetics, knee surgery, longer surgery duration, and presence of drains. All four surgical site infections (SSI) occurred in the SAP group, indicating a potentially lower SSI risk in the PSAP group. Surgeons varied in their frequencies of administering PSAP, suggesting differing approaches to antibiotic prophylaxis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Anesthesiology
Eward J. Melis, Johanna E. Vriezekolk, Julian C. C. van der Laan, Jose M. H. Smolders, Bart J. F. van den Bemt, Maaike G. E. Fenten
Summary: This study assessed the prevalence and predictors of long-term postoperative opioid use in an orthopaedic center using online patient reported measures. The results showed that 12.5% of patients used opioids long-term after surgery, with 3.3% being new users. Preoperative opioid use and affected body region were significant predictors of long-term opioid use.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Orthopedics
Danielle F. F. Peterson, Natasha S. S. McKibben, Michelle M. M. Lawson, Linh N. N. Taylor, Qian Yang, Selene Working, Darin M. M. Friess, Zachary M. M. Working
Summary: This study evaluated the species distribution and resistance patterns of bacterial pathogens causing surgical site infection (SSI) after operative fracture repair, with and without the use of intrawound powdered antibiotic (IPA) prophylaxis. The use of local antibiotic prophylaxis did not result in an increase in the proportion of infections caused by resistant bacterial pathogens.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Orthopedics
Hetzmannseder Sophie, Chang Yuhan, Kittinger Clemens, Kuhn Klaus-Dieter
Summary: The addition of liquid antibiotics negatively affected the mechanical characteristics of the cement mould, with the least impact on the ISO compression strength and ISO flexural modulus. The efficacy against chosen germs was also reduced when liquid antibiotics were added instead of powder.
ORTHOPAEDIC SURGERY
(2021)
Article
Otorhinolaryngology
Mohamed Abdelwahab, Sandro Marques, Isolde Previdelli, Robson Capasso
Summary: This retrospective study analyzed data from obstructive sleep apnea patients who underwent uvulopalatopharyngoplasty and found that perioperative antibiotic prescription was associated with lower complication rates.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Gastroenterology & Hepatology
Huyen Thi Nguyen, Quynh Thi Huong Bui, Tam Van Vo, Hien Thi Thu Pham, Thong Duy Vo
Summary: This study investigated the prophylactic and postoperative antibiotic usage in patients who underwent invasive gastrointestinal surgery, and identified factors associated with postoperative infection. The study emphasized the importance of implementing guidelines for the use of antibiotics to improve treatment outcomes.
BMC GASTROENTEROLOGY
(2022)
Review
Orthopedics
C. Cote, M. Berube, L. Moore, F. Lauzier, L. Tremblay, E. Belzile, M-o Martel, G. Page, Y. Beaulieu, A. M. Pinard, K. Perreault, C. Sirois, S. Grzelak, A. F. Turgeon
Summary: This scoping review examines strategies for preventing long-term opioid use in trauma and orthopaedic surgery patients. The study identifies system-based, educational, multimodal, and psychological strategies as the most promising approaches. Future research should focus on determining which strategies are most effective for high-risk trauma patients, testing strategies that promote appropriate opioid prescribing while preventing misuse, and evaluating their impact on patient-reported and social outcomes.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Fernando D. Albelo, Mitchell Baker, Tina Zhang, Matheus B. Schneider, Julio J. Jauregui, Vidushan Nadarajah, Sean J. Meredith, Jonathan D. Packer, R. Frank Henn
Summary: This study found that pre-operative recreational marijuana use was associated with worse outcomes two years after orthopaedic surgery, including poorer mental health scores, lower activity levels, less pain relief, and lower satisfaction. However, after controlling for confounding variables, marijuana use was not a predictor of any two-year outcomes.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Pharmacology & Pharmacy
Shubham Babu Gupta, Pankaj Wadhwa
Summary: This study evaluated the therapeutic and preventive use of antibiotics in patients who had orthopaedic surgery and found instances of inappropriate antibiotic use among the patients.
JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS
(2022)
Article
Pharmacology & Pharmacy
Shubham Babu Gupta, Pankaj Wadhwa
Summary: This study evaluated the therapeutic and preventive use of antibiotics in patients who underwent orthopaedic surgery. The findings revealed inappropriate use of antibiotics in these surgeries.
JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS
(2022)
Review
Pediatrics
Thomas M. Diehl, James R. Davis, Alice Nsengiyumva, Deborah Igiraneza, Philip Hong, Rosine Umutoni, Dan Neal, Alain Jules Ndibanje, Gisele Juru Bunogerane, Robin T. Petroze, Edmond Ntaganda
Summary: This study retrospectively analyzed 92 gastroschisis patients in a tertiary hospital in Kigali, Rwanda between January 2016 and June 2019. The findings showed a mortality rate of 77%, with 23% of deaths occurring within 48 hours. The study also revealed long hospital stays and regular use of second-line antibiotics. The conclusion suggests the need for further research on antimicrobial resistance in pediatric surgical patients in Rwanda.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Cell & Tissue Engineering
A. B. Lisacek-Kiosoglous, A. S. Powling, A. Fontalis, A. Gabr, E. Mazomenos, F. S. Haddad
Summary: The use of artificial intelligence is rapidly growing in the medical field, with applications in diagnostics, prediction models, and real-time monitoring. However, it is important for clinicians to be aware of its limitations and establish robust reporting and validation frameworks to prevent errors and biases.
BONE & JOINT RESEARCH
(2023)
Review
Medicine, General & Internal
Maria Veronica Cuevas-Gonzalez, Juan Carlos Cuevas-Gonzalez, Leon Francisco Espinosa-Cristobal, Alejandro Donohue-Cornejo, Simon Yovanny Reyes Lopez, Rosa Alicia Saucedo Acuna, Alma Graciela Garcia Calderon, Dalia Abril Guzman Gastelum
Summary: This study aims to evaluate the effectiveness of antibiotics as prophylactic therapy in oral surgery and explore alternatives to pharmacological therapy. The findings indicate that although antibiotics are routinely prescribed, many studies show insufficient evidence to support their use as prophylactic therapy.
