Combinational Therapy Enhances the Effects of Anti-IGF-1R mAb Figitumumab to Target Small Cell Lung Cancer
Published 2015 View Full Article
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Title
Combinational Therapy Enhances the Effects of Anti-IGF-1R mAb Figitumumab to Target Small Cell Lung Cancer
Authors
Keywords
Small cell lung cancer, Cancer treatment, ERK signaling cascade, Signal inhibition, Clinical trials (cancer treatment), Small interfering RNAs, Cell viability testing, MTT assay
Journal
PLoS One
Volume 10, Issue 8, Pages e0135844
Publisher
Public Library of Science (PLoS)
Online
2015-08-20
DOI
10.1371/journal.pone.0135844
References
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- (2013) Beverly A. Teicher BIOCHEMICAL PHARMACOLOGY
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- (2013) B. J. Quinn et al. Cancer Prevention Research
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- (2013) Leonard Girnita et al. CELLULAR AND MOLECULAR LIFE SCIENCES
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- Metformin and the Incidence of Cancer in Patients With Diabetes: A Nested Case-Control Study
- (2013) Shu-Yi Wang et al. DIABETES CARE
- Metformin and mortality
- (2013) S. S. Lund DIABETOLOGIA
- ERK Phosphorylation Is Predictive of Resistance to IGF-1R Inhibition in Small Cell Lung Cancer
- (2013) R. L. Zinn et al. MOLECULAR CANCER THERAPEUTICS
- Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners
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- Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation
- (2012) Arron Sikka et al. CELL CYCLE
- Combined MEK and VEGFR Inhibition in Orthotopic Human Lung Cancer Models Results in Enhanced Inhibition of Tumor Angiogenesis, Growth, and Metastasis
- (2012) O. Takahashi et al. CLINICAL CANCER RESEARCH
- Development of antibody therapeutics for small cell lung cancer
- (2012) Jinbiao Zhan et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- -Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma
- (2012) H. Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) Ana C Magalhaes et al. BRITISH JOURNAL OF PHARMACOLOGY
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
- (2011) D. Iliopoulos et al. CANCER RESEARCH
- The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status
- (2011) M. Ii et al. CLINICAL CANCER RESEARCH
- A Role for IGF-1R–Targeted Therapies in Small-Cell Lung Cancer?
- (2011) Kathy Gately et al. Clinical Lung Cancer
- Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
- (2011) Arun K. Shukla et al. TRENDS IN BIOCHEMICAL SCIENCES
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- (2010) Sandra P. D’Angelo et al. CANCER BIOLOGY & THERAPY
- The Insulin-like Growth Factor-1 Receptor-Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of Childhood Sarcoma
- (2009) R. T. Kurmasheva et al. CANCER RESEARCH
- New Targeted Therapies and Small-Cell Lung Cancer
- (2008) Antonio Rossi et al. Clinical Lung Cancer
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