Review
Medicine, Research & Experimental
Fitri Fareez Ramli
Summary: Mercury, commonly used in skin lightening products, can lead to mercury poisoning. History of mercury exposure, physical examination, and relevant tests are crucial for diagnosis and treatment monitoring. Primary treatment involves discontinuation of skin lightening products, with chelation therapy recommended for symptomatic cases.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Dermatology
Soumya Jagadeesan, Feroze Kaliyadan, Karalikkattil T. Ashique, Aditi Karunakaran
Summary: The survey revealed that bleaching of facial skin and hair is common among young females in India, with a lack of knowledge about the ingredients and side effects of bleaching even among educated individuals. The top motivations for bleaching were to lighten facial hairs, achieve a lighter complexion, and improve skin glow before an event. Awareness about bleaching is low, highlighting the need for increased education and awareness campaigns.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hardoko I. Qudus, Purwadi Purwadi, Iis Holilah, Sutopo Hadi
Summary: The research successfully developed an analysis method to determine the mercury content in skin lightening cream, with good precision and linearity, which could be used for routine chemical analysis of cosmetics products.
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
P. B. Lima, J. A. F. Dias, D. P. Cassiano, A. C. C. Esposito, L. D. B. Miot, E. Bagatin, H. A. Miot
Summary: This study compared the efficacy and tolerability of topical 0.2% Thiamidol vs. 4% hydroquinone for facial melasma. Results showed that both treatments were equally effective in improving melasma, quality of life, and color contrast.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francesco Borgia, Paolo Custurone, Federica Li Pomi, Mario Vaccaro, Clara Alessandrello, Sebastiano Gangemi
Summary: IL-37 and IL-33 are newly identified cytokines that play a role in various inflammatory conditions. This review aims to collect and organize data from multiple studies to establish a comprehensive understanding of their role. The studies assessed mainly focused on atopic dermatitis and immunologic pathways. The collective data suggests a pro-inflammatory role for IL-33 and an anti-inflammatory role for IL-37, potentially linked in an IL-33/IL-37 axis. Early results indicate that both cytokines may serve as markers of disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Michal Gina, Katharina Wichert, Gerald Kutz, Thomas Bruening, Manige Fartasch
Summary: This study aimed to evaluate whether the use of protective creams prior to wearing liquid-proof gloves can mitigate the occlusion effect and skin sensitivity. The results showed that the use of protective creams did not alleviate the occlusion effect, and some creams may have negative effects on the skin barrier function and increase sensitivity.
CONTACT DERMATITIS
(2023)
Article
Allergy
Idy Tam, Kathryn R. Hill, Jin M. Park, JiaDe Yu
Summary: This study used gene transcript profiling to analyze RNA differences in skin sampled by tape stripping, and found that genes encoding epidermal barrier components and inflammatory mediators exhibited changes in transcript abundance in ACD skin compared to ICD or control skin, providing a new approach for molecular marker-based ACD diagnosis.
CONTACT DERMATITIS
(2021)
Review
Dermatology
Natasha Masub, Amor Khachemoune
Summary: Cosmetic skin lightening is a popular practice among communities of color, despite the well-documented health risks. It is important for dermatologists to understand the medical and sociocultural implications of this practice, especially with the changing demographics in the US. This review article provides an overview of the prevalence, ingredients, and health implications of cosmetic skin lightening products, as well as recommendations for counseling patients in a culturally sensitive manner.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Holly Neale, Anna Cristina Garza-Mayers, Idy Tam, JiaDe Yu
Summary: ACD is a delayed hypersensitivity skin reaction to environmental allergens that affects children and adults similarly. However, pediatric patch testing for ACD is less common due to challenges such as smaller surface area for testing and difficulty in cooperation, particularly with younger children. Clinical suspicion guided by patient presentation and history is key in diagnosing ACD in children.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Editorial Material
Dermatology
Theodore Rosen, Jayci Givens
Summary: Skin lightening is a popular trend, particularly in India, the Philippines, other Asian countries, and some Caribbean nations. However, some products used in this practice contain harmful chemicals. The study reveals that skin lightening is most popular in states with diverse populations, including a high percentage of black and Asian Americans.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Allergy
Kate Dear, Amanda Palmer, Rosemary L. Nixon
Summary: The study investigated contact allergy to PFR2 in a single tertiary dermatology centre, and found that even in a selected population of patients, contact allergy to PFR2 is uncommon. The research recommends routine patch testing to a plastics and glues series containing PFR2 for patients exposed to plastics and glues, or who work with wood products.
CONTACT DERMATITIS
(2021)
Article
Pharmacology & Pharmacy
M. T. Beebeejaun, M. B. Brown, V Hutter, L. Kravitz, W. J. McAuley
Summary: The Aron regimen is an unconventional therapy for atopic dermatitis that aims to treat the condition and reduce bacterial colonization on the skin. This study investigates the impact of diluting the components of the therapy on formulation performance, and the results show significant reductions in drug flux, absorption, and skin retention compared to marketed products.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Immunology
Philipp R. R. Esser, Michael Huber, Stefan F. F. Martin
Summary: Maintaining homeostasis is crucial for organismal health. The innate immune system and the unfolded protein response play important roles in inflammation and inflammatory diseases, including allergic contact dermatitis. This review explores the interplay between the innate immune system and cellular stress responses, focusing on the unfolded protein response.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Allergy
Morgan Nguyen, Slaton Case, Nina Botto, Walter Liszewski
Summary: This study identified discussions about allergic contact dermatitis (ACD) across various social media platforms, including content created by patients, physicians, professional organizations, and companies. Instagram had the most content, while Facebook had patient support groups. However, YouTube videos presented poor quality medical information.
CONTACT DERMATITIS
(2022)
Article
Dermatology
Chayada Chaiyabutr, Chutipon Pruksaeakanan, Supisara Wongdama, Suthasanee Prasertsook, Titinun Kumpangsin, Waranya Boonchai
Summary: This study investigated the sales and usage characteristics of sunscreen products in different regions around the world, and found that there are differences in the choices and preferences of sunscreen among different regions. Asia has the highest proportion of consumers choosing high sun protection factor (SPF) products, while Europe has the highest percentage of consumers purchasing <30 SPF products.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Article
Allergy
Waranya Boonchai, Chutipon Pruksaeakanan, Supisara Wongdama, Monthathip Bunyavaree, Titinun Kumpangsin, Chayada Chaiyabutr
Summary: This study aimed to determine the prevalence and trends of contact allergies to formaldehyde and formaldehyde releasers (FRs) in Thailand, as well as analyze the frequency of formaldehyde and FRs mentioned on product labels. The results showed that while contact allergy trends were decreasing, the proportion of products containing FRs remained high.
CONTACT DERMATITIS
(2023)
Letter
Dermatology
Tyng-Shiuan Hsieh, Tom C. Chan, Yung-Tsu Cho, Chia-Yu Chu
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Chia-Yu Chu, Chih-Hung Lee, Hua-En Lee, Yung-Tsu Cho, Chao-Kai Hsu, Tom C. Chan, Song-Chou Hsieh, Kai-Che Wei
Summary: A consensus statement for the management of pemphigus was developed by a panel of dermatology experts from the Taiwanese Dermatological Association, providing practical recommendations for the diagnosis, treatment, and monitoring of pemphigus patients in Taiwan.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Review
Dermatology
Chia-Yu Chu, Tsung-Chieh Yao, I. -Hsin Shih, Chin-Yi Yang, Chan Lee Chin, Sabeera Begum Binti Kader Ibrahim, Suganthi Thevarajah, Leong Kin Fon, Marco Hok-Kung Ho, Chow Chung Mo, Chow Pok Yu, Steven King-Fan Loo, Thomas Luger
Summary: Atopic dermatitis (AD) has seen an increase in incidence among pediatric patients in the Asia-Pacific region. Factors such as genetics, environment, and culture contribute to differences in clinical presentation and prevalence of AD among races. Early treatment, using topical corticosteroids (TCS) as first-line therapy, is important to prevent the development of comorbidities. Pimecrolimus, a topical calcineurin inhibitor (TCI) with less adverse effects than TCS, has been shown to be safe and effective in treating mild to moderate AD, but its use in infants is still restricted in some Asian countries.
DERMATOLOGY AND THERAPY
(2023)
Editorial Material
Dermatology
Aditi Chandra, Matthew J. Davis, Dathan Hamann, Carsten R. Hamann
Article
Genetics & Heredity
S. Ingen-Housz-Oro, V. Schmidt, M. M. Ameri, R. Abe, A. Brassard, A. Mostaghimi, A. S. Paller, A. Romano, B. Didona, B. H. Kaffenberger, B. Ben Said, B. Y. H. Thong, B. Ramsay, E. Brezinova, B. Milpied, C. G. Mortz, C. Y. Chu, C. Sotozono, J. Gueudry, D. G. Fortune, S. M. Dridi, D. Tartar, G. Do-Pham, E. Gabison, E. J. Phillips, F. Lewis, C. Salavastru, B. Horvath, J. Dart, J. Setterfield, J. Newman, J. T. Schulz, A. Delcampe, K. Brockow, L. Seminario-Vidal, L. Joerg, M. P. Watson, M. Goncalo, M. Lucas, M. Torres, M. H. Noe, N. Hama, N. H. Shear, P. O'Reilly, P. Wolkenstein, P. Romanelli, R. P. Dodiuk-Gad, R. G. Micheletti, G. S. Tiplica, R. Sheridan, S. Rauz, S. Ahmad, S. L. Chua, T. H. Flynn, W. Pichler, S. T. Le, E. Maverakis, S. Walsh, L. E. French, M. C. Bruggen
Summary: This study used a DELPHI exercise to establish a multidisciplinary expert consensus on the management of SJS/TEN sequelae. After the survey, a consensus was obtained for 100% of the initially proposed statements. The final consensus will help guide physicians in conducting a prolonged multidisciplinary follow-up of sequelae in SJS-TEN.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Allergy
Jorge Maspero, Norma De Paula Motta Rubini, Jianzhong Zhang, Gloria Sanclemente, Julio Roberto Amador, Mahira Hamdy El Sayed, Alson Chan Wai Ming, Roni P. Dodiuk-Gad, Issam Hamadah, Suganthi Thevarajah, Catalina Rincon-Perez, Elena Fedenko, Yik Weng Yew, Mark B. Y. Tang, Chia-Yu Chu, Kanokvalai Kulthanan, Ozlem Su Kucuk, Anwar Al-Hammadi, Lysel Brignoli, Angelina Tsankova, Sarah El-Samad, Jose Eduardo Neves, Laurent Eckert
Summary: This study examines the prevalence and severity of atopic dermatitis (AD) in adults from various countries/regions. The survey reveals that AD is a common and chronic condition in adults, highlighting its importance beyond childhood.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Dermatology
Hao-Chen Hsu, Po-Wei Huang, Yung-Tsu Cho, Chia-Yu Chu
Summary: We conducted a single-centered retrospective study on pemphigus patients treated with rituximab, investigating the prophylactic efficacy and safety profile of cotrimoxazole. The results showed that the incidence of PJP in the prophylaxis group was significantly lower than that in the control group, and the adverse reactions of cotrimoxazole were tolerable.
DERMATOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Shannaz Nadia Yusharyahya, Valdi Ven Japranata, Ratih Wulan Kusumahapsari, Lili Legiawati, Rinadewi Astriningrum, Karin Rachmani, Chia-Yu Chu
Summary: This study aimed to investigate the consultation pattern in dermatology and venereology from a tertiary hospital perspective during the COVID-19 pandemic. The study found that there was a slight increase in consultation requests during the pandemic era. One-time consultation was the most common type in both periods, with dermatitis being the most prevalent case and Gram staining being the most common examination. There were significant differences in decision conformity, diagnoses, appropriateness, and consult response time between the two groups.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Piergiacomo Calzavara-Pinton, Jarmila Celakovska, Hilde Lapeere, Gregor Holzer, Mona Al-Ahmad, Chia-Yu Chu, Silvia M. Ferrucci, Yoko Kataoka, Mariateresa Rossi, Daria S. Fomina, Wen-Hung Chung, Thrasyvoulos Tzellos, Anne-Claire Fougerousse, Jiangming Wu, Marius Ardeleanu, Zafer E. Ozturk
Summary: This study aimed to characterize patients receiving dupilumab for atopic dermatitis (AD) in a real-world setting. The findings showed that patients had a high disease burden before starting dupilumab treatment, and a significant proportion had type 2 inflammatory comorbidities.
ADVANCES IN THERAPY
(2023)
Article
Allergy
Cynthia X. Chan, Carsten R. Hamann
Summary: This study found that hairdressing tools in both rural and urban areas in the United States release nickel, which contributes to the high prevalence of contact dermatitis among hairdressers. Cheaper tools are more likely to release nickel. These findings highlight the need for clinicians to consider occupational nickel exposure when assessing patients with allergic contact dermatitis, emphasize the importance of using barrier protection, and support the implementation of legislation regulating common allergens.
CONTACT DERMATITIS
(2023)
Article
Allergy
Natsumi Hama, Yuma Sunaga, Hirotaka Ochiai, Akatsuki Kokaze, Hideaki Watanabe, Michiko Kurosawa, Hiroaki Azukizawa, Hideo Asada, Yuko Watanabe, Yukie Yamaguchi, Michiko Aihara, Yoshiko Mizukawa, Manabu Ohyama, Hideo Hashizume, Saeko Nakajima, Takashi Nomura, Kenji Kabashima, Mikiko Tohyama, Akito Hasegawa, Hayato Takahashi, Hiroki Mieno, Mayumi Ueta, Chie Sotozono, Hiroyuki Niihara, Eishin Morita, Marie-Charlotte Bruggen, Iris Motro Feingold, Marc G. Jeschke, Roni P. Dodiuk-Gad, Eva Maria Oppel, Lars E. French, Wei-Ti Chen, Wen-Hung Chung, Chia-Yu Chu, Hye-Ryun Kang, Saskia Ingen-Housz-Oro, Kazutoshi Nakamura, Hirohiko Sueki, Riichiro Abe
Summary: This study presents a novel score, CRISTEN, based on clinical information to predict mortality in patients with SJS/TEN in the early stages. It shows good discrimination and can guide the management and therapy of patients with SJS/TEN.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Jonathan I. Silverberg, Emma Guttman-Yassky, Diamant Thaci, Alan D. Irvine, Linda Stein Gold, Andrew Blauvelt, Eric L. Simpson, Chia-Yu Chu, Zhuqing Liu, Renata Gontijo Lima, Sreekumar G. Pillai, Julien Seneschal
Summary: The study shows that lebrikizumab is effective in treating moderate-to-severe atopic dermatitis in both adolescents and adults, with significant improvements in skin lesions and reduction of itch symptoms during the 16-week induction period.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Allergy
Waranya Boonchai, Surachanee Likittanasombat, Noldtawat Viriyaskultorn, Silada Kanokrungsee
Summary: The study found that females had a higher positive patch test rate than males, but males were more likely to develop occupationally related allergic contact dermatitis. Gender plays a pivotal role in contact dermatitis.
CONTACT DERMATITIS
(2023)
