Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 71, Issue 5, Pages 912-U313Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2014.05.060
Keywords
basal cell carcinoma; eyelid; eyelid margin; in vivo; melanoma; mucosa; reflectance confocal microscopy; tumor
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Funding
- Innov-EYE Project, Interregional Rhone-Alpes Auvergne Clinical Research Group
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Background: Handheld in vivo reflectance confocal microscopy (IVCM) is a new imaging method that allows noninvasive diagnosis of cutaneous tumors but to date it has not been used in the study of eyelid tumors. Objective: We sought to evaluate the suitability of IVCM for eyelid margin tumors. Methods: We prospectively evaluated the IVCM features of 47 eyelid margin lesions, clinically suspicious of malignancy; 35 of these were excised whereas the other 12, with no IVCM malignant features, were followed up for at least 1 year. Clinical, IVCM, and histologic diagnoses were compared. Results: IVCM showed sensitivity and specificity of 100% and 69.2%, respectively, for malignancy (basal cell carcinoma, squamous cell carcinoma, and melanoma). The follow-up of the 12 nonexcised lesions did not show any clinical progression. Limitations: The lesions showing neither clinical nor IVCM features for malignancies were not biopsied in view of the potential functional and aesthetic consequences of eyelid margin surgery. Conclusion: Used with a handheld dermatology-specific microscope, IVCM can play a role in the noninvasive diagnosis of eyelid margin lesions. Further studies are needed to better define diagnostic criteria of eyelid tumors and improve the specificity of this technique.
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