Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis

Exosomes

(2013) Huang-Ge Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer

(2013) V Heinemann et al.   BRITISH JOURNAL OF CANCER

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

(2013) Asfar S. Azmi et al.   CANCER AND METASTASIS REVIEWS

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

(2012) Saumya Pant et al.   BIOCHEMICAL PHARMACOLOGY

miRNA Signatures Associate with Pathogenesis and Progression of Osteosarcoma

(2012) K. B. Jones et al.   CANCER RESEARCH

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Microvesicles: Messengers and mediators of tumor progression

(2011) Khalid Al-Nedawi et al.   CELL CYCLE

Regulation of Cell Migration and Invasion by Specific Modules of uPA: Mechanistic Insights and Specific Inhibitors

(2011) Maria Vincenza Carriero et al.   CURRENT DRUG TARGETS

uPAR as Anti-Cancer Target: Evaluation of Biomarker Potential, Histological Localization, and Antibody-Based Therapy

(2011) Ida K. Lund et al.   CURRENT DRUG TARGETS

The Urokinase Receptor Interactome

(2011) Gabriele Eden et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer therapy trials employing level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

(2011) Manfred Schmitt et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Expression of PTRF in PC-3 Cells Modulates Cholesterol Dynamics and the Actin Cytoskeleton Impacting Secretion Pathways

(2011) Kerry L. Inder et al.   MOLECULAR & CELLULAR PROTEOMICS

Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

(2010) L. Endo-Munoz et al.   CANCER RESEARCH

Modulators of the urokinase-type plasminogen activation system for cancer

(2010) Ralf Hildenbrand et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The urokinase plasminogen activator system in cancer: A putative therapeutic target?

(2009) S. Killeen et al.   DRUG NEWS & PERSPECTIVES

Urokinase plasminogen activator system as a potential target for cancer therapy

(2009) Ahmed H Mekkawy et al.   Future Oncology

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Evolving role of uPA/uPAR system in human cancers

(2008) Kathleen Dass et al.   CANCER TREATMENT REVIEWS

Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front

(2008) Olivier Wever et al.   HISTOCHEMISTRY AND CELL BIOLOGY