Article
Virology
Carla Prezioso, Gabriele Brazzini, Sara Passerini, Carlotta Di Fabio, Terenzio Cosio, Sergio Bernardini, Elena Campione, Ugo Moens, Valeria Pietropaolo, Marco Ciotti
Summary: A study investigated the prevalence of four human polyomaviruses (HPyVs) in actinic keratosis (AK), a premalignant skin lesion. MCPyV was detected in both lesion and non-lesion skin biopsies, while HPyV6, HPyV7, and TSPyV were not detected in any skin samples. This indicates that cutaneous HPyVs may not have a potential role in the development of AK, but more extensive longitudinal studies are needed for definitive conclusions.
Article
Dermatology
Mais M. Saleh, Oriana Awwad, Mariam Hantash Abdel Jalil, Walid Al-Qerem, Maen Saleh, Yazan Al Thaher, Sharif Abdelghany
Summary: Our study revealed low public awareness of actinic keratosis among Jordanians. Although a high proportion of Jordanians use sunscreens, there are deficits in sunscreen practice, indicating an urgent need to increase awareness of actinic keratosis and correct use of sunscreen through health campaigns or healthcare professions.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Jason Thomson, Findlay Bewicke-Copley, Chinedu Anthony Anene, Abha Gulati, Ai Nagano, Karin Purdie, Gareth J. Inman, Charlotte M. Proby, Irene M. Leigh, Catherine A. Harwood, Jun Wang
Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Christopher D. George, Selin Tokez, Loes Hollestein, Luba M. Pardo, Anne J. Keurentjes, Marlies Wakkee, Tamar Nijsten
Summary: Population-based studies on actinic keratoses (AKs) are limited, but this study provides valuable insights on the prevalence, risk factors, and longitudinal outlook of AK. The study found that factors such as male sex, age, lighter hair and eye color, baldness, genetic risk score, and digital photoaging measures were associated with an increased risk of AK. Interestingly, cigarette smokers had a lower risk of AK, and there was no difference in AK presence between treated and untreated participants during follow-up.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Helene Dubois-Pot-Schneider, Gregoire Khairallah, Cyril Brzenczek, Francois Plenat, Frederic Marchal, Marine Amouroux
Summary: Actinic keratoses (AKs) are common sun-damaged skin areas, and there is a need for objective identification of different AK types. This study identified two molecular profiles of AKs, lesional AKs (AK_Ls) with similarity to squamous cell carcinomas and non-lesional AKs (AK_NLs) with similarity to normal skin tissue. The gene expression analysis revealed differences in inflammatory and keratinization-related genes between the two AK classes and suggested the potential of targeting the VEGF pathway for high-risk lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Shahzeb Hassan, Shesly J. Louis, Myriam Fethiere, Danie Dure, Jordan Rosen, Brian W. Morrison
Summary: This study in Haiti examined the prevalence of nonmelanoma skin cancers (NMSC) in patients with oculocutaneous albinism (OCA). The study found that patients with OCA have a higher risk of developing NMSC at an earlier age compared to the general population. Therefore, appropriate skin cancer screening and surveillance should be implemented for this high-risk population group.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Dimitrios Sgouros, Melpomeni Theofili, Theodora Zafeiropoulou, Aimilios Lallas, Zoe Apalla, Alexios Zaras, Konstantinos Liopyris, Georgia Pappa, Eleni Polychronaki, Fiori Kousta, Antonios Panagiotopoulos, Alexander Stratigos, Dimitrios Rigopoulos, Alexander C. C. Katoulis
Summary: This study investigates the reliability of dermoscopic features in differentiating non-pigmented actinic keratosis (NPAK) from pigmented actinic keratosis (PAK). Pigmentation is the strongest dermoscopic predictor for the differentiation between NPAK and PAK.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This analysis reviewed the literature related to the management of AK to provide evidence-based recommendations for treatment. Strong recommendations were made for using ultraviolet protection, topical medications, and cryosurgery to treat AK. Conditional recommendations were made for photodynamic therapy and diclofenac for the treatment of AK.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Microbiology
Jan Kehrmann, Fiona Koch, Skrollan Zumdick, Anna Hoewner, Lara Best, Lars Masshoefer, Sarah Scharfenberg, Michael Zeschnigk, Juergen C. Becker, Dirk Schadendorf, Jan Buer, Alexander Roesch
Summary: Skin microbiome dysbiosis with a Staphylococcus overabundance is observed in actinic keratosis (AK) and squamous skin carcinoma (SCC) patients. This study investigated the impact of diclofenac (DIC) gel and cold atmospheric plasma (CAP) treatments on the lesional microbiome of 59 AK patients, revealing a reduction in total bacterial load and Staphylococcus abundance after both therapies. Responders to CAP treatment showed an increased relative abundance of Corynebacterium genus, while nonresponders had a higher relative abundance of Staphylococcus aureus. These findings highlight the importance of the skin microbiome in AK and suggest its potential as a predictive biomarker.
MICROBIOLOGY SPECTRUM
(2023)
Article
Dermatology
Chryssoula Papageorgiou, Aimilios Lallas, Sofia Magdalini Manoli, Caterina Longo, Michela Lai, Konstantinos Liopyris, Konstantinos Lallas, Elizabeth Lazaridou, Zoe Apalla
Summary: The aim of this study was to investigate the clinical and dermatoscopic criteria that could suggest early invasion and serve as potent predictors to discriminate early SCC from AK. The main positive dermatoscopic predictors of early SCC were dotted/glomerular vessels, hairpin vessels, and white structureless areas, whereas background erythema represented a negative SCC predictor.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Valeria Righi, Camilla Reggiani, Elisabetta Tarentini, Adele Mucci, Alessia Paganelli, Anna Maria Cesinaro, Ema Mataca, Shaniko Kaleci, Barbara Ferrari, Marco Meleti, Cristina Magnoni
Summary: The study assessed the metabolomic fingerprints of AK I, AK II, AK III and SCC, finding that AK I are metabolically active lesions with profiles similar to high-grade AKs and SCC. The negative association of AKs with parakeratosis and positive association with hypertrophy suggest a similar behavior between AKs and SCCs. The findings support the notion that all AKs should be treated independently, as they may be associated with SCC.
Article
Biochemistry & Molecular Biology
Maria Vincenza Chiantore, Marco Iuliano, Roberta Maria Mongiovi, Fabiola Luzi, Giorgio Mangino, Lorenzo Grimaldi, Luisa Accardi, Gianna Fiorucci, Giovanna Romeo, Paola Di Bonito
Summary: Actinic keratosis (AK) is a precursor to cutaneous squamous cell carcinoma (cSCC) and is highly prevalent in the elderly population, particularly among those with sun-exposed skin. This study identified 43 dysregulated microRNAs (miRNAs) in AK samples and validated the expression of several key miRNAs. Pathway analysis revealed that these miRNAs targeted pathways involved in tumorigenesis, highlighting the importance of miRNA regulation in keratinocyte cancer.
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This study provides a summary of 18 evidence-based recommendations for the treatment of actinic keratoses, highlighting the effectiveness of treatments such as ultraviolet protection, topical medications, and cryosurgery. The recommendations are subject to limitations, and future research may alter current treatment guidelines.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Oncology
Ludovica Toffoli, Caterina Dianzani, Serena Bonin, Claudio Guarneri, Fabrizio Guarneri, Roberta Giuffrida, Iris Zalaudek, Claudio Conforti
Summary: Actinic keratosis (AK) is a premalignant skin lesion caused by chronic sun damage. The new formulation of 4% 5-Fluorouracil with once daily application is a highly effective and safe treatment for multiple actinic keratoses.
Article
Medicine, General & Internal
Michael Constantin Kirchberger, Michael Gfesser, Michael Erdmann, Stefan Schliep, Carola Berking, Markus Vincent Heppt
Summary: The study found that tirbanibulin 1% ointment significantly and rapidly reduced the AKASI score in a real-world setting, achieving similar clearance rates as observed in the pivotal trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
