Article
Immunology
Cinthia Mariel Olexen, Diego Alfredo Rosso, Wand Nowak, Daniel Fortunati, Andrea Emilse Errasti, Eugenio Antonio Carrera Silva
Summary: This study aimed to develop a sensitive tracing method to monitor circulating CD207(+) and CD1a(+) cells in patients with LCH. Through flow cytometry and a scoring system, the presence of CD207(+) and CD1a(+) cells was found to be associated with the diagnosis and treatment response of LCH, and these cells could also be detected in some patients without obvious clinical symptoms.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Amal Hasan, Ebaa Al-Ozairi, Nosiba Y. M. Hassan, Shamsha Ali, Rasheed Ahmad, Nada Al-Shatti, Salem Alshemmari, Fahd Al-Mulla
Summary: Severe COVID-19 is associated with a lower frequency of pDCs compared to other circulating DCs, and lower expression levels of HLA-DR, CD123, or CD11c on DCs.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Dermatology
Shahrzad Alimohammadi, Zsofia Penzes, Dorottya Horvath, Agnes Gyetvai, Attila Bacsi, Nikoletta Greta Kis, Akos Nemeth, Jozsef Arany, Attila Olah, Erika Lisztes, Balazs Istvan Toth, Tamas Biro, Attila Gabor Szollosi
Summary: This study compared the transcriptome of monocyte-derived Langerhans cells (moLCs) with that of immature dendritic cells using RNA sequencing. The results showed that moLCs express genes characteristic of LC2 cells and TRPV4. Activation of TRPV4 increased the expression of Langerin and intracellular calcium concentration in moLCs. Furthermore, TRPV4 activation mitigated the inflammatory responses of moLCs by decreasing cytokine production and T-cell activating capability.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Tianyu Cai, Agnes Gouble, Kathryn L. Black, Anna Skwarska, Ammar S. Naqvi, Deanne Taylor, Ming Zhao, Qi Yuan, Mayumi Sugita, Qi Zhang, Roman Galetto, Stephanie Filipe, Antonio Cavazos, Lina Han, Vinitha Kuruvilla, Helen Ma, Connie Weng, Chang-Gong Liu, Xiuping Liu, Sergej Konoplev, Jun Gu, Guilin Tang, Xiaoping Su, Gheath Al-Atrash, Stefan Ciurea, Sattva S. Neelapu, Andrew A. Lane, Hagop Kantarjian, Monica L. Guzman, Naveen Pemmaraju, Julianne Smith, Andrei Thomas-Tikhonenko, Marina Konopleva
Summary: This study demonstrates that UCART123 has selective anti-tumor activity against CD123-positive BPDCN cells, and exhibits strong efficacy in vitro and in mouse models.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Susanne M. Brunner, Andrea Ramspacher, Caroline Rieser, Julia Leitner, Hannah Heil, Michael Ablinger, Julia Tevini, Monika Wimmer, Andreas Koller, Josefina Pinon Hofbauer, Thomas K. Felder, Johann W. Bauer, Barbara Kofler, Roland Lang, Verena Wally
Summary: This study aimed to evaluate the effects of topical diacerein on IMQ-induced psoriasis in mice. The results showed that diacerein significantly alleviated psoriasiform-like skin inflammation and reduced psoriasis-associated splenomegaly. The treatment also resulted in a decreased infiltration of CD11c(+) dendritic cells into the skin and spleen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Mathias Hochgerner, Thomas Bauer, Victoria Zyulina, Elisabeth Glitzner, Sarah Warsi, Joanne E. Konkel, Carmen Tam-Amersdorfer, Wanjun Chen, Stefan Karlsson, Maria Sibilia, Herbert Strobl
Summary: TGF beta 1-BMPR1a signaling is essential for the efficient induction of CD207 during LC differentiation in the steady state, and it plays a role in promoting the expansion and differentiation of LCs, as well as being upregulated in psoriatic skin lesions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Immunology
Binhui Zhou, Wenyi Yang, Wushan Li, Le He, Liaoxun Lu, Lichen Zhang, Zhuangzhuang Liu, Ying Wang, Tianzhu Chao, Rong Huang, Yanrong Gu, Tingting Jia, Qiaoli Liu, Shuanghua Tian, Philippe Pierre, Takahiro Maeda, Yinming Liang, Eryan Kong
Summary: Zdhhc2 plays a crucial role in controlling inflammatory response in psoriasis by regulating interferon-alpha production, and its deficiency leads to reduced inflammation and pDC activation in murine skin. This study sheds light on the potential of targeting Zdhhc2 as a therapeutic approach for inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Masahiro Kamata, Yayoi Tada
Summary: Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. Dendritic cells and macrophages play important roles in the pathogenesis of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xilin Zhang, Xiaorui Li, Yuanyuan Wang, Youdong Chen, Yijun Hu, Chunyuan Guo, Zengyang Yu, Peng Xu, Yangfeng Ding, Qing-Sheng Mi, Jianhua Wu, Jun Gu, Yuling Shi
Summary: Psoriasis is a chronic inflammatory skin disease that is often associated with dyslipidemia. This study found that epidermal Langerhans cells (LCs) in psoriasis patients showed significant morphological and functional differences compared to healthy individuals, including increased neutral lipid levels. Analysis revealed dysregulated gene expression related to lipid metabolism, autophagy, and immune functions in the altered LCs. The findings suggest that dysregulated lipid metabolism influences LC immunofunction, contributing to the development of psoriasis.
Review
Immunology
Jingya Zhang, Siqi Zhao, Xinzhu Xing, Lin Shang, Jiali Cao, Yanling He
Summary: Psoriasis is an autoimmune disease characterized by discolored, scaled patches of skin. Psychological factors have been found to often trigger or worsen the disease. Current research indicates that the nervous and immune systems play a role in the pathogenesis of psoriasis. This article explores the impact of neuropeptides on dendritic cells in psoriasis and suggests that inhibiting these neuropeptides can improve skin lesions, making neuroimmune response a potential direction for new drug treatments and perspectives in psoriasis development.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Vincenzo Maria Perriello, Ilaria Gionfriddo, Roberta Rossi, Francesca Milano, Federica Mezzasoma, Andrea Marra, Orietta Spinelli, Alessandro Rambaldi, Ombretta Annibali, Giuseppe Avvisati, Francesco Di Raimondo, Stefano Ascani, Brunangelo Falini, Maria Paola Martelli, Lorenzo Brunetti
Summary: One-third of adult AML patients have NPM1 mutations, with high expression of CD123 identified as a potential target for therapy in NPM1-mutated leukemic cells, particularly in CD34(+)CD38(-) cells. Targeting CD123 may be effective for treating NPM1-mutated AML, especially in combination with FLT3 mutations.
Article
Pharmacology & Pharmacy
Long Xi, Zibei Lin, Fen Qiu, Shaokui Chen, Ping Li, Xin Chen, Zhenping Wang, Ying Zheng
Summary: This study demonstrates the effectiveness of celastrol-loaded mannose-modified liposomes (CEL-MAN-LPs) in the treatment of psoriasis. The results show that these modified liposomes enhance dendritic cell uptake and inhibit the expression of maturation markers. Intradermal injection of CEL-MAN-LPs significantly improves psoriasis symptoms compared to free drug or unmodified liposomes.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Biochemistry & Molecular Biology
Elvira Pelosi, Germana Castelli, Ugo Testa
Summary: Despite progress in basic research and clinical treatment, acute myeloid leukemia (AML) remains a clinical need for patients of all ages. CD123 is a protein found in certain leukemia cells and is a potential target for therapy due to its higher expression in leukemic cells compared to normal cells. Various drugs targeting CD123, such as antibody-drug conjugates and CAR T cells, have shown promise in clinical trials for AML and other hematologic malignancies. However, more effective therapeutic strategies and combination treatments are needed to improve the outcomes of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mayumi Sugita, Roman Galetto, Hongliang Zong, Nathan Ewing-Crystal, Vicenta Trujillo-Alonso, Nuria Mencia-Trinchant, Winnie Yip, Stephanie Filipe, Celine Lebuhotel, Agnes Gouble, Duane C. Hassane, Julianne Smith, Gail J. Roboz, Monica L. Guzman
Summary: This study reports the design and characterization of allogeneic CD123-targeted CAR-T cells as a therapeutic approach for acute myeloid leukemia.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Kai Ling Liang, Elisa Laurenti, Tom Taghon
Summary: This article discusses the role of interferon regulatory factor 8 (IRF8) in lymphopoiesis and the existence of circulating and tissue-resident CD123+CD127+ lymphoid progenitors.
TRENDS IN IMMUNOLOGY
(2023)
Article
Psychology, Clinical
C. van der Leeuw, L. D. de Witte, A. Stellinga, C. van der Ley, R. Bruggeman, R. S. Kahn, J. van Os, M. Marcelis
PSYCHOLOGICAL MEDICINE
(2020)
Article
Psychiatry
Alexander L. Richards, Antonio F. Pardinas, Aura Frizzati, Katherine E. Tansey, Amy J. Lynham, Peter Holmans, Sophie E. Legge, Jeanne E. Savage, Ingrid Agartz, Ole A. Andreassen, Gabriella A. M. Blokland, Aiden Corvin, Donna Cosgrove, Franziska Degenhardt, Srdjan Djurovic, Thomas Espeseth, Laura Ferraro, Charlotte Gayer-Anderson, Ina Giegling, Neeltje E. van Haren, Annette M. Hartmann, John J. Hubert, Erik G. Jonsson, Bettina Konte, Leonhard Lennertz, Loes M. Olde Loohuis, Ingrid Melle, Craig Morgan, Derek W. Morris, Robin M. Murray, Hakan Nyman, Roel A. Ophoff, Jim van Os, Tracey L. Petryshen, Diego Quattrone, Marcella Rietschel, Dan Rujescu, Bart P. F. Rutten, Fabian Streit, Jana Strohmaier, Patrick F. Sullivan, Kjetil Sundet, Michael Wagner, Valentina Escott-Price, Michael J. Owen, Gary Donohoe, Michael C. O'Donovan, James T. R. Walters
SCHIZOPHRENIA BULLETIN
(2020)
Article
Psychiatry
Lida-Alkisti Xenaki, Costas T. Kollias, Pentagiotissa Stefanatou, Irene Ralli, Rigas-Filippos Soldatos, Stefanos Dimitrakopoulos, Alex Hatzimanolis, Theoni-Fani Triantafyllou, Ioannis Kosteletos, Ilias I. Vlachos, Mirjana Selakovic, Stefania Foteli, Leonidas Mantonakis, Vassiliki Ermiliou, Marina Voulgaraki, Evagelia Psarra, Sinan Guloksuz, Jim van Os, Nikos C. Stefanis
EARLY INTERVENTION IN PSYCHIATRY
(2020)
Article
Psychiatry
Taciana C. C. Ragazzi, Rosana Shuhama, Jorge Sinval, Joao Maroco, Fabiana Corsi-Zuelli, Daiane L. da Roza, Jim van Os, Paulo R. Menezes, Cristina M. Del-Ben
BRAZILIAN JOURNAL OF PSYCHIATRY
(2020)
Article
Psychiatry
Stefania Tognin, Ana Catalan, Gemma Modinos, Matthew J. Kempton, Amaia Bilbao, Barnaby Nelson, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Philip McGuire, Lucia R. Valmaggia
SCHIZOPHRENIA BULLETIN
(2020)
Article
Psychology, Developmental
Christian Rauschenberg, Jim van Os, Matthieu Goedhart, Jan N. M. Schieveld, Ulrich Reininghaus
Summary: The study found that exposure to high levels of bullying victimization leads to more intense negative affect and psychotic experiences in response to stress for youth, while the control group showed no significant differences. This suggests that stress sensitivity may be a potential risk and resilience mechanism linking bullying victimization and youth mental health.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Letter
Psychology, Developmental
Martin Koster Rimvall, Jim van Os, Pia Jeppesen
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Bram Thiel, Marc B. Godfried, Elise C. van Huizen, Bart C. Mooijer, Bouke A. de Boer, Rover A. A. M. van Mierlo, Johan van Os, Bart F. Geerts, Cor J. Kalkman
Article
Psychology, Clinical
Christian Rauschenberg, Ulrich Reininghaus, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Claudia J. P. Simons, Nicole Gunther, Cecile Henquet, Lotta-Katrin Pries, Sinan Guloksuz, Maarten Bak, Jim van Os
Summary: This study found that the JTC bias may contribute to psychosis progression and persistence in individuals with affective dysregulation. However, well-powered prospective studies are needed to replicate these findings.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Clinical
Musa Sami, Diego Quattrone, Laura Ferraro, Giada Tripoli, Erika La Cascia, Charlotte Gayer-Anderson, Jean-Paul Selten, Celso Arango, Miguel Bernardo, Ilaria Tarricone, Andrea Tortelli, Giusy Gatto, Simona del Peschio, Cristina Marta Del-Ben, Bart P. Rutten, Peter B. Jones, Jim van Os, Lieuwe de Haan, Craig Morgan, Cathryn Lewis, Sagnik Bhattacharyya, Tom P. Freeman, Michael Lynskey, Robin M. Murray, Marta Di Forti
Summary: The study found that patients with first episode psychosis (FEP) are more likely to experience psychotic-like effects at higher levels of cannabis use compared to controls. This suggests that FEP patients have a specific psychotomimetic response to heavy cannabis use. Clinicians should be aware of this sensitivity and advise on lower levels of cannabis use to reduce psychotic-like experiences.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Rainald Schmidt-Kastner, Sinan Guloksuz, Thomas Kietzmann, Jim van Os, Bart P. F. Rutten
FRONTIERS IN PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Johan H. Thygesen, Amelia Presman, Jasmine Harju-Seppanen, Haritz Irizar, Rebecca Jones, Karoline Kuchenbaecker, Kuang Lin, Behrooz Z. Alizadeh, Isabell Austin-Zimmerman, Agna Bartels-Velthuis, Anjali Bhat, Richard Bruggeman, Wiepke Cahn, Stella Calafato, Benedicto Crespo-Facorro, Liewe de Haan, Sonja M. C. de Zwarte, Marta Di Forti, Alvaro Diez-Revuelta, Jeremy Hall, Mei-Hua Hall, Conrad Iyegbe, Assen Jablensky, Rene Kahn, Luba Kalaydjieva, Eugenia Kravariti, Stephen Lawrie, Jurjen J. Luykx, Igancio Mata, Colm McDonald, Andrew M. McIntosh, Andrew McQuillin, Rebecca Muir, Roel Ophoff, Marco Picchioni, Diana P. Prata, Siri Ranlund, Dan Rujescu, Bart P. F. Rutten, Katja Schulze, Madiha Shaikh, Frederike Schirmbeck, Claudia J. P. Simons, Timothea Toulopoulou, Therese van Amelsvoort, Neeltje van Haren, Jim van Os, Ruud van Winkel, Evangelos Vassos, Muriel Walshe, Matthias Weisbrod, Eirini Zartaloudi, Vaughan Bell, John Powell, Cathryn M. Lewis, Robin M. Murray, Elvira Bramon
Summary: The study explored the influence of CNVs on cognition, showing that individuals carrying specific schizophrenia-associated CNVs performed worse in verbal recall. No association was found between CNV burden and cognition.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Franck Schurhoff, Baptiste Pignon, Mohamed Lajnef, Romain Denis, Bart Rutten, Craig Morgan, Robin M. Murray, Marion Leboyer, Jim van Os, Andrei Szoke
SCHIZOPHRENIA BULLETIN
(2020)
Article
Pharmacology & Pharmacy
Peter C. Groot, Jim van Os
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2020)
Article
Psychiatry
Stephanie Menghini-Mueller, Erich Studerus, Sarah Ittig, Lucia R. Valmaggia, Matthew J. Kempton, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Rodrigo A. Bressan, Neus Barrantes-Vidal, Celia Jantac, Merete Nordentoft, Stephan Ruhrmann, Garbiele Sachs, Bart P. Rutten, Jim van Os, Anita Riecher-Roessler
EUROPEAN PSYCHIATRY
(2020)