Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model

Cell-SELEX Aptamer for Highly Specific Radionuclide Molecular Imaging of Glioblastoma In Vivo

(2014) Xidong Wu et al.   PLoS One

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Aptamers as Promising Molecular Recognition Elements for Diagnostics and Therapeutics in the Central Nervous System

(2014) Erin M. McConnell et al.   Nucleic Acid Therapeutics

Multifunctional nanoparticles for brain tumor imaging and therapy

(2013) Yu Cheng et al.   ADVANCED DRUG DELIVERY REVIEWS

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells

(2012) Qin Lu et al.   ACTA PHARMACOLOGICA SINICA

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Small-molecule BACE1 inhibitors: a patent literature review (2006 – 2011)

(2012) Gary Probst et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

(2012) Fredrik Jeppsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Aptamers and Their Biological Applications

(2012) Kyung-Mi Song et al.   SENSORS

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

(2011) Yechun Xu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of  -Secretase (BACE1)

(2011) P. Giusti-Rodriguez et al.   JOURNAL OF NEUROSCIENCE

Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability

(2010) Michael S. Malamas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aβ peptide levels and impaired learning behavior in aged rats

(2010) Hideki Takahashi et al.   BRAIN RESEARCH

BACE: Therapeutic target and potential biomarker for Alzheimer's disease

(2010) Geneviève Evin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice

(2010) Ryoichi Kimura et al.   JOURNAL OF NEUROCHEMISTRY

A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A  Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

(2010) H. Fukumoto et al.   JOURNAL OF NEUROSCIENCE

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Aptamers as Innovative Diagnostic and Therapeutic Agents in the Central Nervous System

(2009) Vittorio de Franciscis et al.   CNS & Neurological Disorders-Drug Targets

Single-Agent Laromustine, A Novel Alkylating Agent, Has Significant Activity in Older Patients With Previously Untreated Poor-Risk Acute Myeloid Leukemia

(2009) Gary J. Schiller et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of an aptamer targeting hnRNP A1 by tissue slide‐based SELEX

(2009) Shaohua Li et al.   JOURNAL OF PATHOLOGY

Combining use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus

(2009) Xiaoxiao Cao et al.   NUCLEIC ACIDS RESEARCH

Differential SELEX in Human Glioma Cell Lines

(2009) Laura Cerchia et al.   PLoS One

BACE1 Structure and Function in Health and Alzheimers Disease

(2008) Sarah Cole et al.   Current Alzheimer Research

First Demonstration of Cerebrospinal Fluid and Plasma A  Lowering with Oral Administration of a  -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

(2008) S. Sankaranarayanan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS