Article
Allergy
Zsuzsanna Balla, Zsuzsanna Zsilinszky, Zsofia Polai, Noemi Andrasi, Kinga Viktoria Kohalmi, Dorottya Csuka, Lilian Varga, Henriette Farkas
Summary: This study evaluated the results of complement testing in patients experiencing angioedema while taking angiotensin-converting enzyme inhibitors. The findings revealed that most initial angioedema episodes in the 149 patients occurred in the face, lips, and tongue. The diagnosis of acquired angioedema related to angiotensin-converting enzyme inhibitors is closely linked to the use of these medications.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Emergency Medicine
Jennifer E. Lee, Sean M. Bryant
Summary: Angiotensin converting enzyme inhibitor-induced angioedema is typically easily recognizable, but unilateral angioedema is infrequently reported and rare.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Genetics & Heredity
Carina M. Mathey, Carlo Maj, Annika B. Scheer, Julia Fazaal, Bettina Wedi, Dorothea Wieczorek, Philipp M. Amann, Harald Loffler, Lukas Koch, Clemens Schoffl, Heinrich Dickel, Nomun Ganjuur, Thorsten Hornung, Susann Forkel, Jens Greve, Gerda Wurpts, Par Hallberg, Anette Bygum, Christian Von Buchwald, Malgorzata Karawajczyk, Michael Steffens, Julia Stingl, Per Hoffmann, Stefanie Heilmann-Heimbach, Elisabeth Mangold, Kerstin U. Ludwig, Eva R. Rasmussen, Mia Wadelius, Bernhardt Sachs, Markus M. Nothen, Andreas J. Forstner
Summary: This study investigated the possible association between ACEi/ARB-induced angioedema and HAE genes through molecular genetic screening. The results suggest that HAE-associated mutations are, at best, a rare cause of ACEi/ARB-induced angioedema, and there was no significant association found between ACEi/ARB-induced angioedema and other variants in the investigated genes.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Valerie Gunchick, Rachel L. McDevitt, Elizabeth Choi, Katherine Winslow, Mark M. Zalupski, Vaibhav Sahai
Summary: This study retrospectively analyzed the efficacy of ACE-I/ARBs, statins, and/or aspirin concurrent with first-line systemic therapy in patients with advanced biliary tract cancers (BTCs). The results showed that there was no improvement in progression-free or overall survival in patients who received these medications compared to those who did not.
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Allergy
Michihiro Hide, Takahiko Horiuchi, Isao Ohsawa, Irmgard Andresen, Atsushi Fukunaga
Summary: Hereditary angioedema (HAE) is characterized by unpredictable and painful swelling episodes, with increasing awareness worldwide but low recognition in Japan. Challenges in diagnosis and treatment exist, highlighting the need for greater awareness and solutions in the country.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Cell Biology
Alexandra M. Garvin, Bilal S. Khokhar, Michael P. Czubryt, Taben M. Hale
Summary: Angiotensin II is a key mediator of profibrotic signaling in the heart, impacting cardiac function and mortality. Inhibitors of Ang II production or action, known as RAS inhibitors, are the first line therapeutics for heart failure, with potential for long-lasting effects on cardiac fibroblast responses.
CELLULAR SIGNALLING
(2021)
Article
Immunology
Anne Lesage, Francois Marceau, Christoph Gibson, Brigitte Loenders, Werner Katzer, Horst-Dieter Ambrosi, Jorn Saupe, Alexander Faussner, Evangelia Pardali, Jochen Knolle
Summary: PHA-022121 is a novel small molecule antagonist of the human bradykinin B-2 receptor that shows high affinity, high antagonist potency, and high selectivity, making it a potential treatment and prevention option for hereditary angioedema attacks.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Helene Bachelard, Francois Marceau
Summary: Noscapine and raloxifene were claimed to be bradykinin B2 receptor antagonists, but our study showed that they do not possess this inhibitory effect. This suggests that previous reports might contain misleading information.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Allergy
Marie Douillard, Zineb Deheb, Agathe Bozon, Nadia Raison-Peyron, Olivier Dereure, Lionel Moulis, Angele Soria, Aurelie Du-Thanh
Summary: The study aimed to determine the prevalence of recurrent angioedema in patients with ACEI/ARB-induced bradykinin angioedema after more than 6 months of drug discontinuation. The results showed that 41% of patients still had recurrent angioedema after 6 months. A good response to icatibant and facial localization were predictive for the final diagnosis of ACEI/ARB-induced bradykinin angioedema and mast-cell driven angioedema, respectively.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Letter
Allergy
Aude Belbezier, Melanie Arnaud, Isabelle Boccon-Gibod, Fabien Pelletier, Chloe McAvoy, Delphine Gobert, Olivier Fain, Aurelie Du-Thanh, David Launay, Julien Lupo, Laurence Bouillet
Summary: Acute attacks may occur during the convalescent phase of COVID-19, especially in patients with a history of frequent attacks, but it is unclear whether these acute attacks are specifically triggered by COVID-19.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jonas Ghouse, Gustav Ahlberg, Laura Andreasen, Karina Banasi, Soren Brunak, Michael Schwinn, Ina Holst Larsen, Oscar Petersen, Erik Sorensen, Henrik Ullum, Eva Rye Rasmussen, Niclas Eriksson, Paer Hallberg, Mia Wadelius, Henning Bundgaard, Morten S. Olesen
Summary: A genetic locus at chromosome 14q32.2 was found to be associated with ACE inhibitor-related angioedema in individuals of European descent. Carriers of the risk allele had significantly lower blood pressure, suggesting a potential mechanism linking genetic variants near the bradykinin receptor B2 gene with angioedema risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Physiology
Ana Paula Renno Sierra, Bryan Steve Martinez Galan, Cesar Augustus Zocoler de Sousa, Duane Cardoso de Menezes, Jessica Lais de Oliveira Branquinho, Raquel Leao Neves, Julia Galanakis Arata, Clarissa Azevedo Bittencourt, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Joao Bosco Pesquero, Maria Fernanda Cury-Boaventura
Summary: The study aims to evaluate the role of ACE I/D and BDKRB2 +9/-9 polymorphism on exercise-induced cytokine response. The results showed the association between BDKRB2 genotype and exercise-induced cytokine response related to muscle repair and cardioprotection, while ACE I/D genotype was associated with inflammatory response.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Didi Delalic, Vinko Borcic, Ingrid Prkacin
Summary: This case demonstrates the importance of prompt diagnosis and intervention in rapid onset severe angioedema. Administering icatibant injection can effectively alleviate edema symptoms and stabilize the patient's vital signs.
ACTA CLINICA CROATICA
(2022)
Article
Medicine, General & Internal
Zs. Polai, Zs. Balla, N. Andrasi, K. V. Kohalmi, Gy. Temesszentandrasi, Sz. Benedek, L. Varga, H. Farkas
Summary: The study evaluated clinical follow-up results of 17 patients with C1-INH-AAE, finding that the patients had an average age of 61 years and 33% of them experienced AE attacks provoked by ACE inhibitors. The majority of patients experienced attacks involving the skin, upper airways, tongue/lip, with most having an underlying condition.
JOURNAL OF INTERNAL MEDICINE
(2021)