Review
Virology
Aleksei Suslov, Markus H. Heim, Stefan Wieland
Summary: Infectious diseases cause significant human suffering and socioeconomic burden worldwide. Understanding the interactions between human pathogens and hosts is crucial for developing effective treatment strategies. However, there is a lack of model systems that accurately replicate these interactions. The tropism of hepatitis B (HBV) and C (HCV) viruses for the human liver poses challenges in studying their interactions during the natural progression of these infections. This review summarizes the efforts to advance our knowledge of virus-host interactions in chronic HCV and HBV infection through the analysis of surplus liver biopsy tissue donated by patients.
Article
Immunology
Claudia Hawkins, Minhee Kang, Debika Bhattacharya, Gavin Cloherty, Mary Kuhns, Roy Matining, Chloe Thio, Wadzanai Samaneka, Lameck Chinula, Nyirenda Mulinda, Sharlaa Badal-Faesen, Patcharaphan Sugandhavesa, Javier Lama, Simani Gaseitsiwe, Vera Holzmayer, Mark Anderson, Robert Murphy, Marion Peters
Summary: This study aims to identify serum biomarkers that assess the HBV cccDNA reservoir and predict functional cure in HIV/HBV co-infection. The results support the use of TDF-based DUAL-HBV active ART as the initial treatment option for HIV/HBV co-infection and suggest that HBV RNA could be a useful marker for evaluating treatment response in these patients.
Letter
Gastroenterology & Hepatology
Meng-Hsuan Kuo, Chih-Wei Tseng, Shih-Chieh Shao
Summary: This article provides a link to the paper by El Jamaly et al. for readers to view and access the original research.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Alain H. Litwin, Paula J. Lum, Lynn E. Taylor, Shruti H. Mehta, Judith I. Tsui, Judith Feinberg, Arthur Y. Kim, Brianna L. Norton, Moonseong Heo, Julia Arnsten, Paul Meissner, Alison Karasz, M. Diane Mckee, John W. Ward, Nirah Johnson, Irene Pericot-Valverde, Linda Agyemang, Ellen S. Stein, Aurielle Thomas, Courtney Borsuk, Kendra L. Blalock, Samuel Wilkinson, Katherine Wagner, Jillian Roche, Cristina Murray-Krezan, Jessica Anderson, Vanessa Jacobsohn, Anne F. Luetkemeyer, Oluwaseun Falade-Nwulia, Kimberly Page
Summary: This study compares two patient-centered models of HCV care among people who inject drugs and finds that both models can effectively improve the success rate of treatment. Although medication adherence is higher in the modified directly observed therapy group, there is no significant difference in treatment success rate between the two groups.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Virology
Anni Winckelmann, Ulrik Fahnoe, Priyanka Shukla Bajpai, Magnus Illum Dalegaard, Andreas Lundh, Lene Ryom, Jens Bukh, Nina Weis
Summary: This study investigates the evolution of HBV during tenofovir treatment and identifies potential resistance mutations. The findings suggest that changes at a conserved residue 35 in the HBV RT may be associated with tenofovir resistance. Further studies are needed to assess resistance in vitro and in vivo.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Virology
Modhusudon Shaha, Sumen Majumder, Md Saddam Hossain, Munira Jahan, Raad Rahmat, Ridwana Asma, Mohammad Ariful Islam, Md. Hadisur Rahman, Keshob Chandra Das, Palash Kumar Sarker, Mamun Al Mahtab, Sheikh Mohammad Fazle Akbar, Md Salimullah
Summary: This study reports a novel variant of HBV in a patient co-infected with HCV, and identifies unusual genomic modifications in the HBV genome associated with liver cirrhosis.
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulze zur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: Bulevirtide treatment reduces HDV RNA and ALT levels in patients with chronic hepatitis D, with a dose-dependent effect.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hyun ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H. Bortz, Ariel S. Wirchnianski, Monika Paroder, Karen Fehn, Leana Serrano-Rahman, Rachelle Babb, Uzma N. Sarwar, Denise Haslwanter, Ethan Laudermilch, Catalina Florez, M. Eugenia Dieterle, Rohit K. Jangra, J. Maximilian Fels, Karen Tong, Margarette C. Mariano, Olivia Vergnolle, George Georgiev, Natalia G. Herrera, Ryan J. Malonis, Jose A. Quiroz, Nicholas C. Morano, Gregory J. Krause, Joseph M. Sweeney, Kelsie Cowman, Stephanie Allen, Jayabhargav Annam, Ariella Applebaum, Daniel Barboto, Ahmed Khokhar, Brianna J. Lally, Audrey Lee, Max Lee, Avinash Malaviya, Reise Sample, Xiuyi A. Yang, Yang Li, Rafael Ruiz, Raja Thota, Jason Barnhill, Doctor Y. Goldstein, Joan Uehlinger, Scott J. Garforth, Steven C. Almo, Jonathan R. Lai, Morayma Reyes Gil, Amy S. Fox, Kartik Chandran, Tao Wang, Johanna P. Daily, Liise-anne Pirofski
Summary: Convalescent plasma therapy may be beneficial for COVID-19 patients, especially those under 65 years old. Pretransfusion antibody titers are associated with treatment efficacy.
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulzezur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: In this study, it was found that bulevirtide is effective in inhibiting the entry of hepatitis D virus and reducing the progression of liver disease in patients with chronic hepatitis B. The recommended dosage of bulevirtide is 2 mg or 10 mg per day.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cell Biology
Fanyun Kong, Fulong Zhang, Xiangye Liu, Suping Qin, Xiaoying Yang, Delong Kong, Xiucheng Pan, Hongjuan You, Kuiyang Zheng, Renxian Tang
Summary: Calcium acts as a ubiquitous second messenger in HBV infection, elevating cytosolic Ca2+ levels through different channels and promoting viral replication. Targeting Ca2+ signaling is an effective approach for the treatment of HBV infection.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Virology
Xuelian Deng, Dan Liu, Maelenn Pailine Delcourt, Huihui Gao, Lu Zhou, Daniel Candotti
Summary: Between 2011 and 2021, a total of 869,633 blood donations were collected from prequalified donors in Dalian, China. Only 0.12% of the samples were confirmed to be positive for hepatitis B virus (HBV). Testing for hepatitis delta virus (HDV) antibodies in 2175 donations revealed that only 0.09% of the samples showed weak reactivity, but they were confirmed to be false positives upon repeat testing. Among the confirmed occult HBV infection (OBI) samples, only one non-Chinese donor showed repeated reactivity to HDV antibodies, suggesting that HDV/HBV coinfection does not play a significant role in the genesis of OBI. Overall, the data indicated a very low prevalence of HDV infection among blood donors in Liaoning province, Northeast China.
Article
Gastroenterology & Hepatology
Jun Zi, Yu-Huan Li, Xiao-Mei Wang, Hong-Qin Xu, Wen-Hui Liu, Jia-Yue Cui, Jun-Qi Niu, Xiu-Mei Chi
Summary: The screening practices for hepatitis D virus (HDV) are diverse and non-standardized worldwide, leading to uncertainty in the exact prevalence of HDV. This study aimed to estimate the prevalence of HDV and investigate the trends in viral marker quantity in patients with hepatitis D in Jilin Province, China. The results showed a correlation between HDV infection and HBsAg level, anti-HDAg level, and HBV DNA level.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Infectious Diseases
Yao Hu, Xia Wu, Yingzi Ye, Lijing Ye, Shuzhen Han, Xiaohong Wang, Hui Yu
Summary: This study investigated the associations between hepatic histology and clinical characteristics in treatment-naive children with chronic hepatitis B (CHB) in Shanghai, China. The results showed substantial heterogeneity in inflammatory and fibrotic levels among these children, with serum ALT levels being a strong indicator of hepatic inflammation and fibrosis severity. Moderate fibrosis and cirrhosis were also observed in children aged 3 years or younger.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Mandana Khalili, Jesse Powell, Helen H. Park, Dylan Bush, Jessica Naugle, Margaret Ricco, Catherine Magee, Grace Braimoh, Barry Zevin, J. Konadu Fokuo, Carmen L. Masson
Summary: The HCV testing and treatment program implemented in large homeless shelters in San Francisco and Minneapolis was successful, with over 80% of patients achieving HCV cure. The study highlights the importance of integrated models in HCV elimination efforts among people experiencing homelessness.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Immunology
Jade Pattyn, Greet Hendrickx, Alex Vorsters, Pierre Van Damme
Summary: The coverage of hepatitis B vaccines is increasing, and the effective implementation of vaccination programs has significantly reduced the morbidity and mortality related to hepatitis B.
JOURNAL OF INFECTIOUS DISEASES
(2021)
