Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 58, Issue 5, Pages 802-809Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2008.01.005
Keywords
-
Categories
Ask authors/readers for more resources
Background: The relationship between herpesvirus reactivation and graft-versus-host disease (GVHD) after allogeneic stern cell transplantation (allo-SCT) is unclear. Objective: We sought to examine the relationship between human herpesvirus (HHV) reactivation and rash/GVHD after allo-SCT by prospective evaluation. Methods: Fifteen patients who had received allo-SCT underwent prospective serial examinations for human herpesvirus 6 (HHV-6), HHV-7, cytomegalovirus, and Epstein-Barr virus DNA in the blood by polymerase chain reaction and real-time polymerase chain reaction. Serum interferon gamma, interleukins 4 and 10, tumor necrosis factor alpha, and soluble interleukin 2 receptor (sIL-2R) were also measured. Results: In 10 of 15 patients, macular/papular eruptions were seen after allo-SCT and GVHD was diagnosed. in 8 patients with rash, HHV-6 DNA levels correlated with the cutaneous manifestation. Interleukin 10 and sIL-2R also increased in association with rash. Limitations: The number of patients in our study was relatively small. Not all patients were examined for cytokines and sIL-2R. Conclusions: HHV-6 reactivation may be involved in the pathogenesis of rash/GVHD after allo-SCT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available