Article
Agronomy
Xukai Li, Zhiyong Shi, Jianhua Gao, Xingchun Wang, Kai Guo
Summary: Haplotype blocks reduce genotyping effort and assist in mapping candidate genes. The CandiHap software allows rapid and robust haplotype analysis and candidate identification from sequencing data. It can be used on various operating systems and any species.
MOLECULAR BREEDING
(2023)
Article
Plant Sciences
Cong Feng, Xingwei Wang, Shishi Wu, Weidong Ning, Bo Song, Jianbin Yan, Shifeng Cheng
Summary: Haplotype identification, characterization, and visualization are crucial in population genomics. HAPPE is a user-friendly tool that uses coloring of Excel tables to display genotypes and haplotypes, along with additional information such as phylogenetic trees and GWAS values.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Genetics & Heredity
Ning Ma, Yucheng Sun, Yanan Kong, Yiyao Jin, Fengxue Yu, Lianfeng Liu, Lei Yang, Wenxuan Liu, Xia Gao, Dianwu Liu, Xiaolin Zhang, Lu Li
Summary: In this study, the relationship between single nucleotide polymorphisms in MMR genes and the occurrence and development of HBV infection was investigated. Through case-control studies, key polymorphisms associated with HBV susceptibility, spontaneous clearance, and cancerization were identified. The findings suggest a close association between these genetic variations and the occurrence and development of HBV infection.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Kojin Tsuchiya, Yuna Zayasu, Yuichi Nakajima, Nana Arakaki, Go Suzuki, Noriyuki Satoh, Chuya Shinzato
Summary: Understanding the structure and connectivity of coral populations is crucial for marine conservation. This study reveals the complex migration tendencies and population dynamics of coral populations in the Nansei Islands, influenced by heterogeneity in ocean currents and local environments.
Article
Medicine, General & Internal
Abram Bunya Kamiza, Segun Fatumo, Mwiza Gideon Singini, Chih-Ching Yeh, Tinashe Chikowore
Summary: The study suggests a causal association between chronic hepatitis B virus infection and extrahepatic cancers, particularly cervical and gastric cancers.
Article
Psychiatry
Maria Hernandez-Lorca, Astrid Sevelsted, Jens Richardt Mollegaard Jepsen, Casper-Emil T. Pedersen, Julie B. Rosenberg, Parisa Mohammadzadeh, Morten Arendt Rasmussen, Mikkel Erlang Sorensen, Niels Bilenberg, Birte Glenthoj, Birgitte Fagerlund, Bo Chawes, Jakob Stokholm, Rebecca Kofod Vinding, Bjorn Ebdrup, Klaus Bonnelykke
Summary: This study uses deep neuropsychiatric phenotyping to investigate the impact of COVID-19 lockdown on the mental health outcomes of children. The results suggest that the lockdown has negative consequences for the mental health of children, especially those with a genetic vulnerability to ADHD.
PSYCHIATRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chune Zhu, Youpeng Qi, Xiangyan Wang, Baohong Mi, Changze Cui, Shaopeng Chen, Zhidong Zhao, Fangfang Zhao, Xiu Liu, Jiqing Wang, Bingang Shi, Jiang Hu
Summary: This study identified genetic variations in the ACACB gene that are associated with meat quality traits in Gannan yaks. A missense variation in exon 37 of ACACB resulted in an amino acid change and was correlated with cooking loss rate and yak carcass weight. The presence of different haplotypes also had effects on meat quality, with some haplotypes decreasing Warner-Bratzler shear force and drip loss rate, while others increased cooking loss rate and eye muscle area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yiwen Long, Lanhua Tang, Yangying Zhou, Shushan Zhao, Hong Zhu
Summary: This study suggests a causal association between the gut microbiota and cancer, providing new insights for further research on the mechanisms and clinical implications of microbiota-mediated cancer.
Article
Genetics & Heredity
Mikhail Churnosov, Tatyana Belyaeva, Evgeny Reshetnikov, Volodymyr Dvornyk, Irina Ponomarenko
Summary: This study investigated the association between filaggrin (FLG) gene and atopic dermatitis (AD) in Caucasians from Central Russia. The results showed that multiple SNPs of the FLG gene were associated with AD and had an impact on the disease. Additionally, protective haplotypes were identified. In silico analysis revealed that the AD risk variants and their proxies had effects on various tissue/organs, particularly the skin.
Review
Psychology, Clinical
Isabell Brikell, Christie Burton, Nina Roth Mota, Joanna Martin
Summary: ADHD is a common and highly heritable neurodevelopmental disorder, with recent research showing a complex genetic architecture involving multiple genes and neurobiological processes. Genetic studies suggest that ADHD diagnosis shares a large proportion of genetic risks with continuously distributed traits of ADHD in the population, as well as with genetic risks implicated in other neurodevelopmental, psychiatric, and somatic phenotypes.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Zhenwei Yang, Zhiquan Lian, Guangbin Liu, Ming Deng, Baoli Sun, Yongqing Guo, Dewu Liu, Yaokun Li
Summary: This study selected 90 SNPs associated with milk production traits in dairy cows and verified 36 loci as genetic markers, presenting new and effective haplotypes for further breeding strategies.
ANIMAL BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hueng-Chuen Fan, Kuo-Liang Chiang, Kuang-Hsi Chang, Chuan-Mu Chen, Jeng-Dau Tsai
Summary: Comorbidities are common in children with epilepsy, and ADHD is one of the most prevalent comorbidities. The burden of ADHD in children with epilepsy is high and can negatively impact their clinical outcomes, psychosocial aspects, and quality of life. Stimulants have shown effectiveness and safety in treating comorbid ADHD, but further research is needed to establish their safety in randomized, double-blinded, placebo-controlled trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Triin Laisk, Maarja Lepamets, Mariann Koel, Erik Abner, Andres Metspalu, Reedik Maegi
Summary: Pernicious anemia is a rare condition with a clear autoimmune basis, often caused by autoimmune gastritis, and associated with a higher risk of other autoimmune disorders. A genome-wide association study meta-analysis identified significant associations between pernicious anemia and genetic risk factors in genes such as PTPN22, PNPT1, HLA-DQB1, IL2RA, and AIRE.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
David Wragg, Sonia E. Eynard, Benjamin Basso, Kamila Canale-Tabet, Emmanuelle Labarthe, Olivier Bouchez, Kaspar Bienefeld, Malgorzata Bienkowska, Cecilia Costa, Ales Gregorc, Per Kryger, Melanie Parejo, M. Alice Pinto, Jean-Pierre Bidanel, Bertrand Servin, Yves Le Conte, Alain Vignal
Summary: Honey bee subspecies originate from specific geographical areas and have been imported to different regions. To better understand Western European honey bee populations, researchers conducted a genome sequence and SNP genotype analysis.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Pharmacology & Pharmacy
F. H. M. Ali, M. K. Smatti, M. A. Elrayess, A. A. Al Thani, H. M. Yassine
Summary: Autoimmune diseases are common conditions in which the immune system attacks healthy cells. They have a high prevalence, especially among women. Genetic and environmental factors play a role in their development. Various diagnostic and treatment methods are available, but they can have side effects and high costs. Recent studies have identified genetic factors associated with susceptibility to these diseases.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Psychology, Developmental
Emma Sciberras, Pooja Patel, Mark A. Stokes, David Coghill, Christel M. Middeldorp, Mark A. Bellgrove, Stephen P. Becker, Daryl Efron, Argyris Stringaris, Stephen V. Faraone, Susannah T. Bellows, Jon Quach, Tobias Banaschewski, Jane McGillivray, Delyse Hutchinson, Tim J. Silk, Glenn Melvin, Amanda G. Wood, Anna Jackson, George Loram, Lidia Engel, Alicia Montgomery, Elizabeth Westrupp
Summary: The study found that COVID-19 restrictions had negative impacts on children with ADHD, leading to reduced physical activity and outdoor time, decreased enjoyment in activities, and increased screen time and negative emotions. However, some parents reported positive changes in their children, such as increased family time during this period.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Psychology, Developmental
Ann C. Childress, Henry C. Foehl, Jeffrey H. Newcorn, Stephen Faraone, Benjamin Levinson, Akwete L. Adjei
Summary: The study on the long-term safety and symptom control of extended-release methylphenidate in children aged 4 to <6 years showed that most treatment-emergent adverse events were of mild or moderate severity, weight and height z scores as well as obesity rates decreased significantly, with insomnia reported in 9% and hypertension in 6.7%, while ADHD symptom control was maintained.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychology, Developmental
Corentin J. Gosling, Samuele Cortese, Eric Konofal, Michel Lecendreux, Stephen V. Faraone
Summary: This study examined the association between sleep disturbances and ADHD symptoms over a 9-year period, finding that sleep disturbances at age 13 predicted increased ADHD symptoms at age 18, while ADHD symptoms at age 9 predicted increased sleep disturbances at age 13. The findings highlight the importance of identifying these issues for preventive interventions.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Alessio Bellato, John Perna, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Samuele Cortese, Stephen Faraone
Summary: This study conducted a systematic review and meta-analysis to investigate the association between attention-deficit/hyperactivity disorder (ADHD) and eye disorders as well as altered visual function. The findings suggest that ADHD is associated with an increased risk of certain vision problems and visual function impairments, but not with structural changes in the eye.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Renee Kleine Deters, I. Hyun Ruisch, Stephen Faraone, Catharina A. Hartman, Marjolein Luman, Barbara Franke, Jaap Oosterlaan, Jan K. Buitelaar, Jilly Naaijen, Andrea Dietrich, Pieter J. Hoekstra
Summary: Genetic risk for antisocial and aggressive behaviors is related to amygdala shape alterations, indicating genetic sharing across different DBD and ASB and aggression-related phenotypes. Additionally, vertex-based shape analysis is useful in genetic studies of ASB, aggression, and DBDs.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Stephen V. Faraone, Roberto Gomeni, Joseph T. Hull, Soumya A. Chaturvedi, Gregory D. Busse, Zare Melyan, Welton O'Neal, Jonathan Rubin, Azmi Nasser
Summary: Early response to viloxazine ER treatment predicts efficacy outcome in ADHD patients, and the predictive model is consistent across different age groups.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Developmental
Yanli Zhang-James, Ali Shervin Razavi, Martine Hoogman, Barbara Franke, Stephen V. Faraone
Summary: This systematic review examines the literature on the development of magnetic resonance imaging (MRI)-based diagnostic classifiers for attention-deficit/hyperactivity disorder (ADHD) using machine learning (ML). It found variations in MRI modalities, ML models, cross-validation and testing methods, and sample sizes among the studies. The review also highlights the importance of large multi-modal imaging datasets and the potential combination with other types of data to develop clinically useful imaging classification tools for ADHD in the future.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Psychiatry
Mai Uchida, Qasim Bukhari, Maura DiSalvo, Allison Green, Giulia Serra, Chloe Hutt Vater, Satrajit S. Ghosh, Stephen V. Faraone, John D. E. Gabrieli, Joseph Biederman
Summary: This study developed a quantitative predictive model for bipolar disorder using machine learning algorithms and clinical data. The predictors included behavioral problems, school functioning, and anxiety/depression and aggression scales. The results have important clinical and scientific implications for assessing the risk of bipolar disorder in children.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Biographical-Item
Neurosciences
Stephen V. Faraone
BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Nevena V. Radonjic, Alessio Bellato, Nayla M. Khoury, Samuele Cortese, Stephen V. Faraone
Summary: This study conducted a systematic review and meta-analysis to assess the efficacy, acceptability, and tolerability of nonstimulants in adults with ADHD. The results showed that atomoxetine, guanfacine, and viloxazine ER were significantly more effective than placebo in treating ADHD. However, atomoxetine had poorer tolerability compared to placebo.
Article
Psychology, Developmental
Elisabeth F. Callen, Tarin L. Clay, Jillian Alai, David W. Goodman, Lenard A. Adler, Joel Shields, Stephen V. Faraone
Summary: This study aimed to assess the changes in quality care for adults with ADHD from 2010 to 2020. The results showed an increase in the achievement of quality measures over time, but none of the patients achieved more than six out of ten measures in any year. Small but significant effects were observed for sex, race, ethnicity, practice ownership, practice type, and age.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Endocrinology & Metabolism
Ali Zare Dehnavi, Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Summary: This study found that approximately 49.2% of adults with type 2 diabetes (T2D) met the diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD). However, there was no direct association between these symptoms and cardiovascular diseases or diabetic control. Further research is needed to clarify the relationship between ADHD symptoms, diabetic control, and comorbidities.
JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
John Perna, Alessio Bellato, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Stephen V. Faraone, Samuele Cortese
Summary: This study conducted a systematic review and meta-analysis to investigate the association between vision and/or eye disorders and Autism Spectrum Disorder (ASD). The findings suggest that ASD is associated with functional vision problems and structural alterations of the eye. However, further research is needed to clarify the causal relationship between ASD and vision problems.
MOLECULAR PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
John Perna, Alessio Bellato, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Stephen V. Faraone, Samuele Cortese
MOLECULAR PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Lisa O'Connor, Stephanie Carbone, Anthony Gobbo, Hilary Gamble, Stephen Faraone
Summary: This article provides an overview of pharmacological treatment options for pediatric attention-deficit disorder (ADHD), including stimulant and non-stimulant medications. It offers detailed information on new medication options, such as anesthetic agents, extended-release forms, and novel adjunctive medications. These additions are beneficial for clinicians in their treatment toolbox.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)