Article
Clinical Neurology
Hanne Lie Kjaerstad, Karin Schioler Hellum, Nora Hilde Haslum, Mads Nathaniel Lopes, Thomas Saaby Noer, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: This study used virtual reality technology to explore emotion regulation ability in bipolar disorder patients and their unaffected first-degree relatives. The results showed that patients with bipolar disorder had difficulties in down-regulating negative emotions in the virtual reality task compared to healthy controls, while unaffected relatives did not differ from healthy controls. This suggests that virtual reality technology may provide a more sensitive measure compared to traditional tasks.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Batuhan Ayik, Hatice Kaya, Rumeysa Tasdelen, Neslihan Sevimli
Summary: This study investigated retinal changes in patients with bipolar disorder and their healthy siblings using optical coherence tomography (OCT), and explored these findings as potential endophenotype candidates. The results showed that GCL+IPL thicknesses were significantly correlated with functionality of patients and severity of the disorder.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Anne Bjertrup, Julian Macoveanu, Heidemarie Laurent, Mala Moszkowicz, Megan Kate Finnegan, Ida Egmose, Patrick MacDonald Fisher, Rene Ernst Nielsen, Anne Katrine Pagsberg, Lars Vedel Kessing, Mette Vaever, Kamilla Miskowiak
Summary: The study found that mothers with bipolar disorder exhibit abnormal neural responses when viewing their own infants' faces, including lower dlPFC response and abnormal fronto-limbic connectivity. This may affect their emotional responses and caregiving behavior towards their infants in real-life interactions.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neuroimaging
Natania A. Crane, Fini Chang, Kerry L. Kinney, Heide Klumpp
Summary: The study found that greater putamen activity and less amygdala activity in response to angry faces were related to greater social anxiety severity in individuals with Social Anxiety Disorder. However, there was no relationship between brain activity in response to fearful faces and social anxiety severity. Clinical features revealed that levels of anhedonia and general anxiety symptoms may contribute to social anxiety severity.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Hailin Ai, Yuwei Cui, Nihong Chen
Summary: The human ability to process multiple items simultaneously is affected by whether those items are represented by distinct neural populations. In this study, using fMRI, we found that adding a second face to occupy both visual hemifields increased the neural response, but adding more faces within the same visual field decreased the response. This pattern was observed in various regions of the brain involved in visual processing. A similar trend was also found in behavior, indicating a limited perceptual bandwidth for processing multiple faces simultaneously. These findings suggest that adding signals with nonoverlapping cortical representation enhances perception, while adding signals that compete for representation resources impairs perception.
Review
Clinical Neurology
Ellie Xu, Lynn Nguyen, Rebecca Hu, Caitlin M. Stavish, Ellen Leibenluft, Julia O. Linke
Summary: This meta-analysis investigates the role of the uncinate fasciculus (UF) in bipolar disorder (BD). The findings suggest aberrant UF microstructure, potentially related to alterations in myelination, as a mechanism of BD. However, the results regarding first-degree relatives (REL) are inconsistent. Further studies examining the role of UF in individuals at familial risk for BD are warranted.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Peter A. Kirk, Avram J. Holmes, Oliver J. Robinson
Summary: Previous research has suggested a link between the amygdala-dorsomedial prefrontal circuit, trait anxiety/vigilance, and anxiogenic stimuli. This study aimed to investigate if this circuit is chronically engaged in individuals with high anxiety and threat vigilance. While no evidence of this relationship was found in the analysis of resting-state fMRI data, a relationship was observed between threat vigilance behavior and intrinsic amygdala-periaqueductal gray connectivity in exploratory analyses.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Mareike Bayer, Oksana Berhe, Isabel Dziobek, Tom Johnstone
Summary: Recent research suggests that personal relevance of faces can be decoded within 100 ms, with representations starting prior to structural encoding in the visual cortex and involving prefrontal and midline regions. The study highlights the importance of updating models of face perception to include rapid detection of personal relevance in cortical circuitry.
Article
Psychology, Multidisciplinary
Daniela Ballotta, Riccardo Maramotti, Eleonora Borelli, Fausta Lui, Giuseppe Pagnoni
Summary: This study aimed to identify the neural circuits involved in processing positive and negative valence of facial expressions and words. Using fMRI, the researchers found that early visual cortices were the only areas showing differential response to negative and positive valence, with faces eliciting stronger activations. The effect was mediated by the amygdala for positive faces and the fusiform face area for negative faces, while for words, it was mainly imputable to the primary visual cortex.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Guangfei Li, Yu Chen, Shefali Chaudhary, Clara S. Li, Dongmei Hao, Lin Yang, Chiang-Shan R. Li
Summary: This study examines the relationship between hypothalamic resting state functional connectivity (rsFC), sleep dysfunction, cognitive performance, and subjective mood states. The results show that sleep dysfunction is associated with negative emotions and altered hypothalamic-insula rsFC, particularly in men.
Article
Psychology, Multidisciplinary
Abigail L. Hogan, Molly Winston, Jamie Barstein, Molly Losh
Summary: This study found differences in pupillary responses to emotional faces in parents of autistic individuals compared to controls. The timing of pupillary response was associated with ASD-related features in ASD parents, and there were correlations between pupillary responses in parents and their autistic children.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Electrochemistry
Yuuka Kokubo, Hidetaka Asoh
Summary: This study demonstrated the formation of titanium with two chemically distinct faces through two-step direct current bipolar anodization. Different thicknesses of oxide films on the front and back of the titanium bipolar electrode (BPE) resulted in different colors. Site-selective film formation could be achieved even on a ball-shaped BPE.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Neurosciences
Jessica Taubert, Susan G. Wardle, Clarissa T. Tardiff, Amanda Patterson, David Yu, Chris I. Baker
Summary: The study found that clutter diminishes the selectivity of the face-selective network for peripheral faces, although information about their retinal location is still retained.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Ryan Elson, Denis Schluppeck, Alan Johnston
Summary: Previous brain imaging studies have examined the cortical responses to object categories and faces. However, the brain's response to faces that deviate substantially from average has not been extensively investigated. This study used a face space based on PCA to generate faces ranging from average to heavily caricatured, and found that increasing caricature level resulted in more consistent patterns of fMRI response in the right fusiform face area (FFA). These findings suggest a potential recruitment of object-selective regions in processing caricatured faces.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychiatry
Timea Csulak, Gyorgyi Csabi, Robert Herold, Viktor Voros, Sara Jeges, Andras Hajnal, Marton Aron Kovacs, Maria Simon, Marton Herold, Akos Levente Toth, Tamas Tenyi
Summary: Minor physical anomalies are somatic markers of aberrant neurodevelopment, and the higher prevalence of these signs among the relatives of bipolar I patients confirms them as endophenotypes. The study found that minor physical anomalies were more common in specific regions like the ear, head, mouth and trunk among the relatives of bipolar I patients, indicating a potential genetic component.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Developmental
Simone P. Haller, Joel Stoddard, Christian Botz-Zapp, Michal Clayton, Caroline MacGillivray, Gretchen Perhamus, Kelsey Stiles, Katharina Kircanski, Ian S. Penton-Voak, Yair Bar-Haim, Marcus Munafo, Kenneth E. Towbin, Melissa A. Brotman
Summary: The study aimed to examine the effect of interpretation bias training on youths with chronic irritability. While engaging the proposed behavioral target, there was no statistically significant improvement in clinical outcomes.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychology, Developmental
Jodi Zik, Christen M. Deveney, Jarrod M. Ellingson, Simone P. Haller, Katharina Kircanski, Elise M. Cardinale, Melissa A. Brotman, Joel Stoddard
Summary: Despite being distinct from aggression, irritability is highly correlated with anger. Child-reported outward expression of anger overlaps significantly with irritability, providing empirical support for the clinical categorization of irritability as a proneness to express anger outwardly. The informant source explains a substantial portion of response variance.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychology, Clinical
Maria K. Wilson, Danielle Cornacchio, Melissa A. Brotman, Jonathan S. Comer
Summary: In this age range, ARI-P scores showed large associations with other irritability index and small-to-large associations with aggression, anxiety, depression, and attention problems, supporting the convergent and concurrent validity of the ARI-P when used with children in this younger age range.
Article
Neurosciences
Gang Chen, Daniel S. Pine, Melissa A. Brotman, Ashley R. Smith, Robert W. Cox, Paul A. Taylor, Simone P. Haller
Summary: Trials play a crucial role in task-based neuroimaging, impacting statistical efficiency and condition-level generalizability. Increasing both trial and subject sample sizes can improve statistical efficiency more effectively than focusing on subjects alone, and trial-level modeling may be necessary for accurately assessing effect estimates with small trial size.
Review
Psychiatry
Melissa M. Batt, Aviva K. Olsavsky, Shaleah Dardar, Celeste St John-Larkin, Rachel L. Johnson, Mary D. Sammel
Summary: This review provides an update on the course of illness and treatments for bipolar disorder in the perinatal period, highlighting unique presentation of postpartum mood episodes, treatment risk balance, and the need for further research on medication safety and efficacy.
CURRENT PSYCHIATRY REPORTS
(2022)
Editorial Material
Psychology, Developmental
Melissa A. Brotman, Katharina Kircanski
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Psychology, Developmental
Ka Shu Lee, Cheyanne N. Hagan, Mina Hughes, Grace Cotter, Eva McAdam Freud, Katharina Kircanski, Ellen Leibenluft, Melissa A. Brotman, Wan-Ling Tseng
Summary: This study aims to summarize the methods and results of using functional magnetic resonance imaging (fMRI) to investigate neural dysfunction in childhood irritability. The findings showed small sample sizes, heterogeneous sample characteristics, and a lack of neural activation convergence. Therefore, there is a need for standardized irritability assessments and more homogeneous fMRI tasks to study the neural mechanisms of irritability.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Meeting Abstract
Psychology, Developmental
Hanna Stevens, Aviva K. Olsavsky, Paula Riggs
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Review
Psychology, Developmental
Alecia C. Vogel, Melissa A. Brotman, Amy Krain Roy, Susan B. Perlman
Summary: This study highlights the importance of studying positive emotion dysregulation and proposes a developmental approach to examining it within the context of temperament. The research findings suggest that dysregulation of positive emotion is associated with externalizing symptoms and clinical impairment in youth.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Editorial Material
Psychology, Developmental
Douglas K. Novins, Robert R. Althoff, Melissa A. Brotman, Samuele Cortese, Melissa DelBello, Alysa Doyle, Stacy S. Drury, Lisa Fortuna, Jean A. Frazier, Mary Fristad, Schuyler W. Henderson, Elizabeth McCauley, Christel Middeldorp, Wanjiku F. M. Njoroge, Cynthia E. Rogers, Tonya White
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Wan-Ling Tseng, Reut Naim, Amanda Chue, Shannon Shaughnessy, Jennifer Meigs, Daniel S. Pine, Ellen Leibenluft, Katharina Kircanski, Melissa A. Brotman
Summary: This study used a network analytic approach and smartphone-based ecological momentary assessment to investigate the relationship between irritability and other anxiety and mood symptoms. The results showed that frustration was the most central node in the networks of between-prompt symptoms, while sadness and anger were the most central nodes in the networks of momentary symptoms. Furthermore, anger was broadly positively related to sadness, mood lability, and worry across individuals.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Aviva K. Olsavsky, C. Neill Epperson
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Meeting Abstract
Neurosciences
Isaac Morales, Olufunmilayo Telli, Kyunghun Lee, Ramaris German, Katharina Kircanski, Melissa A. Brotman, Ellen Leibenluft, Daniel Pine, Elise Cardinale
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Reut Naim, Shannon Shaughnessy, Ashley Smith, Katharina Kircanski, Melissa A. Brotman
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Theodore Doykos, Matt Jones, Simone Haller, Melissa A. Brotman, Joel Stoddard
BIOLOGICAL PSYCHIATRY
(2022)