Article
Psychiatry
Marta Pardo, Jose L. Matali, Jenym Sivoli, Vila-Badia Regina, Anna Butjosa, Montse Dolz, Bernardo Sancgez, Ana Barajas, Nuria Del Cacho, Iris Banos, Susana Ochoa, Judith Usall
Summary: The study found a higher prevalence of cannabis use in EOP patients compared to healthy controls and identified differences in clinical presentation between cannabis users and non-users. The risk of developing EOP was significantly higher in individuals with a history of cannabis use, especially daily users. Early detection and tailored treatment programs for adolescents with cannabis use are necessary.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychology, Clinical
Nina Pocuca, Nicholas Chadi, Francis Vergunst, Sophie Parent, Sylvana M. Cote, Michel Boivin, Richard E. Tremblay, Jean R. Seguin, Natalie Castellanos-Ryan
Summary: Research aims to fill the knowledge gap in adolescent polysubstance use and determines the better explanation for cannabis use outcomes in early adulthood. It finds that youth with early-onset cannabis use show distinct polysubstance use profiles, and those who follow an escalating or frequent (with cigarettes) pattern have consistently higher cannabis use frequency and problems compared to those who started later in adolescence or adulthood.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Neurosciences
Grace Blest-Hopley, Aisling O'Neill, Robin Wilson, Vincent Giampietro, Sagnik Bhattacharyya
Summary: The study found that adolescent-onset cannabis users have slower verbal learning compared to non-users, with disruptions in brain activation in certain regions affecting learning speed.
PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carmen Almodovar-Paya, Maria Guardiola-Ripoll, Maria Giralt-Lopez, Carme Gallego, Pilar Salgado-Pineda, Salvador Miret, Raymond Salvador, Maria J. Munoz, Luisa Lazaro, Amalia Guerrero-Pedraza, Mara Parellada, Maria Carrion, Manuel J. Cuesta, Teresa Maristany, Salvador Sarro, Lourdes Fananas, Luis F. Callado, Barbara Arias, Edith Pomarol-Clotet, Mar Fatjo-Vilas
Summary: This study investigates the association between the Neuritin 1 gene (NRN1) and early-onset schizophrenia (EO). Through genetic association analysis and neuroimaging studies, the researchers found convergent evidence of the association between NRN1 and EO. These findings highlight the role of neurotrophins in the pathophysiology of schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Developmental
William E. Copeland, Sherika N. Hill, Lilly Shanahan
Summary: The objective of this study was to examine the associations between early cannabis use and adult functioning using four commonly used definitions of early cannabis use-related to timing, dose, duration, and associated symptoms. The results showed that daily, continued-over-time cannabis use beginning in adolescence had the most detrimental impact on a range of adult outcomes. Stopping early use did not completely eliminate later risks, but was associated with fewer negative outcomes.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
Dustin Hammers, Sara Nemes, Taylor Diedrich, Ani Eloyan, Kala Kirby, Paul Aisen, Joel Kramer, Kelly Nudelman, Tatiana Foroud, Malia Rumbaugh, Alireza S. Atri, Gregory Day, Ranjan R. Duara, Neill S. Graff-Radford, Lawrence T. Honig, David C. Jones, Joseph F. Masdeu, Mario Mendez, Erik U. Musiek, Chiadi Onyike, Meghan Riddle, Emily Rogalski, Steve J. Salloway, Sharon J. Sha, Raymond Scott Turner, Sandra S. Weintraub, Thomas A. Wingo, David Wolk, Bonnie C. Wong, Maria C. Carrillo, Bradford D. Dickerson, Gil G. Rabinovici, Liana Apostolova
Summary: This study investigated the limitations of learning slopes in early-onset dementias and aimed to highlight the sensitivity of learning slopes in discriminating disease severity in cognitively normal participants and those diagnosed with early-onset dementia. The results showed that learning slopes are highly sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The rating for the importance of this study is 8 out of 10.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Reza Moshfeghinia, Bahare Oji, Mehrnaz Hosseinzadeh, Mohammad Pourfridoni, Jamshid Ahmadi
Summary: This article describes a case of Frontotemporal dementia (FTD) caused by marijuana abuse, highlighting the profound impact of cannabis consumption on brain structure and chemistry, including the potential for neurodegenerative disorders like FTD.
Article
Psychology, Developmental
Christy R. Rogers, Xi Chen, Seh-Joo Kwon, Nancy L. McElwain, Eva H. Telzer
Summary: This study demonstrates the significant impact of early attachment on adolescent emotion regulation, with insecurely attached adolescents showing greater behavioral and neural dysregulation when confronted with affective cues. Furthermore, parental presence buffers the behavioral and neural dysregulation in early insecurely attached adolescents towards socially aversive cues, emphasizing the importance of caregivers in promoting regulation in their offspring.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Emese Kroon, Lauren Kuhns, Janna Cousijn
Summary: This study found that there was no difference in working memory performance between cannabis users and controls, but the presence of distracting cannabis words reduced working memory load-related brain activity in multiple regions in cannabis users compared to controls.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Ke Jia, Ya Li, Mengyuan Gong, Hui Huang, Yonghui Wang, Sheng Li
Summary: This study investigated the changes in working memory representation induced by training using fMRI and TMS techniques. The results suggest that training does not alter the necessity of sensory area in representing WM information, but may change the coding format of the stored stimulus in this region. Additionally, training can lead to more robust maintenance of WM content in higher-order parietal areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Developmental
Manqi Zhang, Lena Palaniyappan, Mengjie Deng, Wen Zhang, Yunzhi Pan, Zebin Fan, Wenjian Tan, Guowei Wu, Zhening Liu, Weidan Pu
Summary: The study reveals that early-onset schizophrenia patients exhibit thalamic imbalance similar to adult-onset schizophrenia, characterized by increased sensorimotor-thalamic connectivity and decreased prefrontal-thalamic connectivity. Specifically, strengthened connectivity with the salience network and disrupted lateral thalamic nuclear connectivity are prominent features in early-onset schizophrenia.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Psychology, Clinical
Taylor Hatchard, Aziza Byron-Alhassan, Ola Mioduszewski, Katherine Holshausen, Stacey Correia, Allison Leeming, Gladys Ayson, Carley Chiasson, Peter Fried, Ian Cameron, Andra Smith
Summary: This study utilized fMRI to examine neural activation and performance on a working memory task in young adults. While there were no differences in performance, cannabis users showed significant differences in brain activation, including altered functional connectivity. This suggests potential compensatory mechanisms in the brain due to sustained cannabis use.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2021)
Article
Neurosciences
W. Lawn, N. Fernandez-Vinson, C. Mokrysz, G. Hogg, R. Lees, K. Trinci, K. Petrilli, A. Borissova, S. Ofori, S. Waters, P. Michor, M. B. Wall, T. P. Freeman, H. Curran
Summary: This study investigated the association between chronic cannabis use and cognitive function in adolescent and adult users, finding that users had worse verbal episodic memory compared to controls, but no significant differences in spatial working memory or response inhibition. There was no evidence for heightened adolescent vulnerability to cannabis-related cognitive impairment.
PSYCHOPHARMACOLOGY
(2022)
Article
Immunology
Justin P. Yuan, Tiffany C. Ho, Sache M. Coury, Rajpreet Chahal, Natalie L. Colich, Ian H. Gotlib
Summary: Exposure to early life stress may increase the risk of maladaptive outcomes in adolescents by disrupting the association between the immune system and neural processes involved in socioemotional functioning.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Maitane Oscoz-Irurozqui, Carmen Almodovar-Paya, Maria Guardiola-Ripoll, Amalia Guerrero-Pedraza, Noemi Hostalet, Raymond Salvador, Maria Isabel Carrion, Teresa Maristany, Edith Pomarol-Clotet, Mar Fatjo-Vilas
Summary: The study investigates the interaction between cannabis use and genetic variants at the endocannabinoid receptor genes on brain activity in first-episode psychosis. Results suggest a joint effect of cannabinoid receptor genotypes and cannabis use on brain function, particularly in regions relevant to the reward circuit.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Max A. van den Boom, Kai J. Miller, Nick F. Ramsey, Dora Hermes
Summary: The study investigated how the design and surgical placement of electrode grids impact the usability of ECoG measurements, finding that grid configurations with a higher number of densely-packed, large-size electrodes are optimal for capturing the dynamics of hand gesture information. In informative regions of the primary sensorimotor cortex, a grid configuration with 3x3 electrodes, 8 mm inter-electrode distance, and 3 mm electrode size achieved the highest decoding accuracy at around 70% three-class classification accuracy.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Anatomy & Morphology
Alessio Fracasso, Anna Gaglianese, Mariska J. Vansteensel, Erik J. Aarnoutse, Nick F. Ramsey, Serge O. Dumoulin, Natalia Petridou
Summary: This study found that positive blood oxygenation level-dependent (BOLD) responses are correlated with high-frequency band (HFB) responses in electrodes responding to visual stimulation, while negative BOLD responses are associated with an absence of HFB power responses and an unexpected decrease in alpha power responses.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Engineering, Biomedical
L. C. M. Bruurmijn, M. Raemaekers, M. P. Branco, M. J. Vansteensel, N. F. Ramsey
Summary: This study investigates the effects of denervation on the movement representation on the ipsilateral sensorimotor cortex, and the results show that decoding both hands from the same hemisphere is possible even years after denervation. This suggests that implantation of motor-electrodes for BCI control may only need to cover a single hemisphere, making surgery less invasive and providing more options for individuals with lateralized damage to the motor cortex.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Rehabilitation
Mariana P. Branco, Elmar G. M. Pels, Femke Nijboer, Nick F. Ramsey, Mariska J. Vansteensel
Summary: The development of effective Brain-Computer Interfaces (BCIs) relies on collaboration between end-users, caregivers, and researchers. This study compared the opinions of prospective BCI users, caregivers, and BCI researchers regarding BCI applications, mental strategies, and timing of information. The results highlighted the need to align research agendas with the needs of end-users and caregivers to advance the development and implementation of BCIs.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Neurosciences
Mark L. C. M. Bruurmijn, Mathijs Raemaekers, Mariana P. Branco, Nick F. Ramsey, Mariska J. Vansteensel
Summary: There is evidence suggesting the importance of the contralateral sensorimotor areas in movement generation, but the exact role of the ipsilateral sensorimotor cortex in unilateral movement control remains unclear. High-field fMRI data showed hand movement representation in the ipsilateral sensorimotor hand area, supporting the notion of transcallosal integrative processes for optimal coordination of hand movements.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Maxime Verwoert, Mariska J. Vansteensel, Zachary Freudenburg, Erik J. Aarnoutse, Frans S. S. Leijten, Nick F. Ramsey, Mariana P. Branco
Summary: The study demonstrates that four hand gestures can be effectively decoded using a single bipolar pair, showing the potential for further development of motor-based BCIs.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Sumeet Singla, Robert Block
Summary: The purpose of this study is to evaluate the development of tolerance in recreational marijuana users after acute pulmonary administration of THC. The results showed that chronic users develop tolerance to euphoria, requiring higher plasma concentrations compared to occasional users to achieve the same degree of highness.
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Mansoureh Fahimi Hnazaee, Maxime Verwoert, Zachary Freudenburg, Sandra M. A. van der Salm, Erik J. Aarnoutse, Sacha Leinders, Marc M. Van Hulle, Nick F. Ramsey, Mariska J. Vansteensel
Summary: This study investigates whether non-invasive scalp electroencephalography (EEG) can predict the performance of brain-computer interfaces (BCIs) based on electrocorticography (ECoG). By analyzing the experimental results of participants with locked-in syndrome (LIS) and healthy participants, it was found that EEG can detect the characteristics observed in ECoG signals. These findings provide new insights for predicting the performance of ECoG-BCIs.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Iris I. A. Groen, Giovanni Piantoni, Stephanie Montenegro, Adeen Flinker, Sasha Devore, Orrin Devinsky, Werner Doyle, Patricia Dugan, Daniel Friedman, Nick F. Ramsey, Natalia Petridou, Jonathan Winawer
Summary: Neural responses to visual stimuli exhibit complex temporal dynamics, which can be captured by a computational model. This study demonstrates the integration of various temporal features, such as subadditive temporal summation, adaptation, and slower dynamics at low contrast, within the same experiment. The model accurately captures the temporal dynamics in different regions of the visual cortex.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Julia Berezutskaya, Zachary Freudenburg, Mariska J. Vansteensel, Erik J. Aarnoutse, Nick F. Ramsey, Marcel A. J. van Gerven
Summary: This study optimized and validated a decoding approach for speech reconstruction from sensorimotor cortex recordings, demonstrating the importance of machine learning model optimization for achieving high accuracy reconstruction and the potential of sensorimotor cortex reconstruction for intelligible speech. This has significant implications for the development of next-generation BCI technology.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Mariska J. Vansteensel, Mariana P. Branco, Sacha Leinders, Zac F. Freudenburg, Anouck Schippers, Simon H. Geukes, Michael A. Gaytant, Peter H. Gosselaar, Erik J. Aarnoutse, Nick F. Ramsey
Summary: Implantable brain-computer interfaces (BCIs) can be used to restore communication with individuals with locked-in syndrome (LIS). However, further validation and speed improvement are needed for future clinical implementation. This article provides procedures and recommendations for recruitment, inclusion, implantation, and training of participants with LIS, aiming to contribute to the methodological standardization of implantable BCI research.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Psychology, Multidisciplinary
Robert I. Block, Gerry Jager, Maartje Luijten, Nick F. Ramsey
Summary: The study found that long-term marijuana use can affect memory function in American adolescents, but not in Dutch adolescents. Furthermore, more marijuana use was associated with lower total recall and more perseverative errors. The influence of nationality on marijuana's cognitive effects should be further examined in future studies comparing effects across different nationalities or cultures.
PSYCHOLOGICAL REPORTS
(2022)
Article
Clinical Neurology
Mariana P. Branco, Elmar G. M. Pels, Ruben H. Sars, Erik J. Aarnoutse, Nick F. Ramsey, Mariska J. Vansteensel, Femke Nijboer
Summary: The research assessed the preferences of potential cBCI users regarding applications, control strategies, and timing of information, finding that there was not much difference in opinions between individuals diagnosed with progressive and sudden onset disorders.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Psychology, Multidisciplinary
Robert Block, Heather L. Bair, James F. Carillo
PSYCHOLOGICAL REPORTS
(2020)
Letter
Psychology, Clinical
Robert I. Block, Heather L. Bair, James F. Carillo
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2020)
