Article
Multidisciplinary Sciences
Vuk Aleksic, Jovana Todorovic, Nenad Miladinovic, Nemanja Aleksic, Vojislav Bogosavljevic, Marko Durovic, Svetlana Kocic, Radmila Aleksic, Milos Jokovic
Summary: This observational cohort study examined the ligamentum flavum in patients with lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) to investigate the pathophysiology of neurogenic claudication. The thickening of ligamentum flavum in LSS patients was found to be the main cause of stenosis, and histological analysis revealed differences in the amount of collagen and elastic fibers between the groups. These findings support the inflammatory theory of spinal neurogenic claudication.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Baoliang Zhang, Guanghui Chen, Xiaoxi Yang, Tianqi Fan, Xi Chen, Zhongqiang Chen
Summary: Pathological changes in the ligamentum flavum, including hypertrophy and ossification, have unclear pathogenesis. MicroRNAs play a crucial role in regulating gene expression and revealing the pathological mechanisms of these changes. Studies have shown the importance of miRNAs in regulating ligamentum flavum pathology.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Yang Duan, Jianjun Li, Sujun Qiu, Songjia Ni, Yanlin Cao
Summary: This study identifies TCF7 as an important factor in the formation of HLF. TCF7 expression is elevated in HLF tissues and cells and is positively correlated with the severity of HLF. Inhibition of TCF7 reduces hyper-proliferation and fibrosis in HLF cells, while overexpression of TCF7 enhances these processes. The study further reveals the involvement of SNAI2 and miR-4306 in the TCF7-mediated regulation of HLF. These findings suggest that TCF7 could be a potential therapeutic target for HLF.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Joohyun Kim, Woo-Keun Kwon, Hyunwook Cho, Subum Lee, Jang-Bo Lee, Jung-Yul Park, Dong Uk Jin, Eui Yub Jung, Junseok W. Hur
Summary: This study reveals that ligamentum flavum hypertrophy is an important factor in lumbar spinal canal stenosis and has a significant impact on clinical symptoms and outcomes compared to other components such as disc bulging and facet hypertrophy.
Article
Medicine, General & Internal
Kei Ito, Hideki Kise, Satoshi Suzuki, Sota Nagai, Kurenai Hachiya, Hiroki Takeda, Soya Kawabata, Daiki Ikeda, Keiyo Takubo, Shinjiro Kaneko, Nobuyuki Fujita
Summary: Oxidative stress plays a role in degenerative musculoskeletal conditions, including lumbar spinal canal stenosis. This study aimed to investigate the connection between oxidative stress and hypertrophy of the ligamentum flavum (LF) in the lumbar spine. The findings suggest that oxidative stress may be a therapeutic target for LF hypertrophy, and the antioxidant N-acetylcysteine shows potential as a treatment for lumbar spinal canal stenosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Yanlin Cao, Jianjun Li, Sujun Qiu, Songjia Ni, Yang Duan
Summary: This study investigates the role and potential mechanism of ACSM5 in the accumulation of lipids in the ligamentum flavum (LF), a major cause of lumbar spinal canal stenosis (LSCS). The findings show that ACSM5 plays an important role in regulating LF lipid accumulation and suggests potential therapeutic interventions for the treatment of LF hypertrophy-induced LSCS by targeting lipid deposition.
Article
Radiology, Nuclear Medicine & Medical Imaging
Komakech Richard Lukecha, Erem Geoffrey, Mubuuke A. Gonzaga, Bugeza Sam
Summary: MRI lumbar spine evaluation findings among young adult patients with low back pain in Uganda showed a higher rate of disc degeneration compared to previous reports. Age and pain distribution were predictors of developing disc desiccation.
BMC MEDICAL IMAGING
(2022)
Article
Medicine, General & Internal
Kaifan Yang, Yanlin Chen, Xin Xiang, Yanling Lin, Chengshuo Fei, Zesen Chen, Zhongming Lai, Yongpeng Yu, Ruiqian Tan, Jiale Dong, Junxiong Zhang, Peng Li, Liang Wang, Zhongmin Zhang
Summary: This study investigated the role of EGF in ligamentum flavum hypertrophy (LFH) and its potential molecular mechanism. The results showed that EGF promotes the synthesis of collagen I and collagen III via the TGF-01/Smad3 signaling pathway, contributing to LFH.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Neurosciences
Tarush Rustagi, Ehud Mendel, Sue A. Ferguson, Abhinandan Reddy Mallepally, William J. Thomas, Riley E. Splittstoesser, Jonathan S. Dufour, William S. Marras
Summary: This study compared spine structure measures between different postures and found significant differences. The additional information gathered from upright MRI may be beneficial for accurate diagnosis and future spine research.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Peng Li, Chunlei Liu, Lei Qian, Zhenyu Zheng, Chenglong Li, Zhengnan Lian, Jie Liu, Zhongmin Zhang, Liang Wang
Summary: The study identified that miR-10396b-3p suppresses progression of LFH by inhibiting IL-11, leading to decreased expression of collagen I and III. The mechanical stress-miR-10396b-3p-IL-11 axis plays a key role in the pathological progression of LFH.
Article
Biochemistry & Molecular Biology
Kai Zhang, Xin Wang, Li-Ting Zeng, Xiao Yang, Xiao-Fei Cheng, Hai-Jun Tian, Chen Chen, Xiao-Jiang Sun, Chang-Qing Zhao, Hui Ma, Jie Zhao
Summary: This study aimed to investigate the role of circular RNAs and microRNAs in the pathogenesis of hypertrophic ligamentum flavum (LF) and lumbar spinal stenosis (LSS), with a focus on circPDK1. The results showed that overexpression of circPDK1 promoted the proliferation, migration, and fibrosis-related protein expression in LF, while miR-4731-5p had opposite effects.
Article
Immunology
Peng Li, Cheng-shuo Fei, Yan-lin Chen, Ze-sen Chen, Zhong-ming Lai, Rui-qian Tan, Yong-peng Yu, Xin Xiang, Jia-le Dong, Jun-xiong Zhang, Liang Wang, Zhong-min Zhang
Summary: This study identified six potential autophagy-related genes (ARGs) that participate in the fibrosis process of ligamentum flavum hypertrophy (LFH) and play a crucial role in its molecular mechanism. These potential genes, including FN1, TGF beta 1, NGF, HMOX1, CAT, and SIRT1, may serve as specific therapeutic targets for the treatment of LFH.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hamidullah Salimi, Akinobu Suzuki, Hasibullah Habibi, Kumi Orita, Yusuke Hori, Akito Yabu, Hidetomi Terai, Koji Tamai, Hiroaki Nakamura
Summary: Hypertrophy of the ligamentum flavum is associated with disrupted elastic fibers, increased cellularity, collagen, and calcification. The upregulated expression of biglycan (BGN) in hypertrophied ligamentum flavum promotes cell proliferation, morphological changes, myofibroblastic differentiation, and cell migration. BGN plays a crucial role in the pathophysiology of ligamentum flavum hypertrophy.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Iria Da Cuna-Carrera, Alejandra Alonso-Calvete, Eva M. Lantaron-Caeiro, Mercedes Soto-Gonzalez
Summary: Chronic low back pain is a common dysfunction in the spine, and studies have found changes in the thickness of abdominal muscles in patients with this condition.
Article
Medicine, Research & Experimental
Bin Pan, Tianqun Huo, Menghan Cao, Li Jing, Xuanxiang Luo, Zhe Qu, Hu Feng, Feng Yuan, Kaijin Guo
Summary: The study identified ADAM10 as a key gene in the development of ligamentum flavum hypertrophy (LFH), showing that it promotes cell proliferation through the activation of the PI3K/AKT pathway. These findings contribute to a better understanding of the cellular mechanisms of LFH and suggest a novel therapeutic target and clinical approach.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Wataru Narita, Ryota Takatori, Yuji Arai, Masateru Nagae, Hitoshi Tonomura, Tatsuro Hayashida, Taku Ogura, Hiroyoshi Fujiwara, Toshikazu Kubo
JOURNAL OF NEUROSURGERY-SPINE
(2016)
Article
Clinical Neurology
Gen Mori, Yasuo Mikami, Yuji Arai, Takumi Ikeda, Masateru Nagae, Hitoshi Tonomura, Ryota Takatori, Koshiro Sawada, Hiroyoshi Fujiwara, Toshikazu Kubo
JOURNAL OF NEUROSURGERY-SPINE
(2016)
Article
Medicine, General & Internal
Masateru Nagae, Yasuo Mikami, Kentaro Mizuno, Tomohisa Harada, Takumi Ikeda, Hitoshi Tonomura, Ryota Takatori, Hiroyoshi Fujiwara, Toshikazu Kubo
Article
Rheumatology
Daigo Taniguchi, Ryo Oda, Kazuya Ikoma, Shogo Toyama, Ryota Takatori, Kan Imai, Yusuke Hara, Koshiro Sawada, Daisaku Tokunaga, Hiroyoshi Fujiwara, Toshikazu Kubo
MODERN RHEUMATOLOGY
(2017)
Article
Medicine, General & Internal
Kunihiko Hosoi, Hitoshi Tonomura, Ryota Takatori, Masateru Nagae, Yasuo Mikami, Toru Osawa, Yuji Arai, Hiroyoshi Fujiwara, Toshikazu Kubo
Article
Clinical Neurology
Shingo Nagashima, Masateru Nagae, Yuji Arai, Hitoshi Tonomura, Ryota Takatori, Tsuyoshi Sukenari, Hiroyoshi Fujiwara, Koshiro Sawada, Yasuo Mikami, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2017)
Article
Cell & Tissue Engineering
Munehiro Sakata, Hitoshi Tonomura, Tomonori Itsuji, Hidenobu Ishibashi, Ryota Takatori, Yasuo Mikami, Masateru Nagae, Ken Ichi Matsuda, Yasuhiko Tabata, Masaki Tanaka, Toshikazu Kubo
TISSUE ENGINEERING PART A
(2018)
Article
Orthopedics
Munehiro Sakata, Hitoshi Tonomura, Tomonori Itsuji, Hidenobu Ishibashi, Ryota Takatori, Yasuo Mikami, Masateru Nagae, Ken Ichi Matsuda, Masaki Tanaka, Toshikazu Kubo
JOURNAL OF ORTHOPAEDIC SURGERY
(2018)
Article
Clinical Neurology
Shigeyuki Kitanaka, Ryota Takatori, Yuji Arai, Masateru Nagae, Hitoshi Tonornura, Yasuo Mikarni, Nozornu Inoue, Taku Ogura, Hiroyoshi Fujiwara, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2018)
Article
Clinical Neurology
Ryota Takatori, Taku Ogura, Wataru Narita, Tatsuro Hayashida, Hitoshi Tonomura, Yasuo Mikami, Masateru Nagae, Kazuya Ikoma, Toshikazu Kubo
CLINICAL SPINE SURGERY
(2019)
Article
Orthopedics
Chien-Chou Pan, Peter Simon, Alejandro A. Espinoza Orias, Ryota Takatori, Howard S. An, Gunnar B. J. Andersson, Nozomu Inoue
SKELETAL RADIOLOGY
(2020)
Article
Orthopedics
Tomonori Itsuji, Hitoshi Tonomura, Hidenobu Ishibashi, Yasuo Mikami, Masateru Nagae, Ryota Takatori, Takashi Tanida, Ken-Ichi Matsuda, Masaki Tanaka, Toshikazu Kubo
Summary: This study demonstrates that HGF promotes NP cell proliferation under hypoxic conditions through HIF-1α, MAPK, PI3K/Akt, and STAT3-mediated signaling pathways. Inhibiting these pathways may be a potential therapeutic strategy for disc degeneration in hypoxic conditions.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Surgery
Yoichiro Hatta, Hitoshi Tonomura, Masateru Nagae, Ryota Takatori, Yasuo Mikami, Toshikazu Kubo
SPINE SURGERY AND RELATED RESEARCH
(2019)
Article
Surgery
Ryota Takatori, Taku Ogura, Wataru Narita, Tatsuro Hayashida, Kazuya Tanaka, Hitoshi Tonomura, Masateru Nagae, Yasuo Mikami, Toshikazu Kubo
SPINE SURGERY AND RELATED RESEARCH
(2018)