Article
Chemistry, Physical
Christian T. McHugh, Phillip G. Durham, Sebastian Atalla, Michele Kelley, Nicholas J. Bryden, Paul A. Dayton, Rosa T. Branca
Summary: Recent research has demonstrated the detection of bare gas microbubbles at low concentrations typically used in clinical contrast-ultrasound studies using hyperCEST. However, in vivo translation faces challenges due to saturation of the gas-phase hyperpolarized Xe-129 within the lungs. This study shows that perfluorocarbon nanodroplets, when acoustically reverted back into microbubble form, can serve as a phase-change contrast agent for dual-modality MR/US imaging.
Article
Chemistry, Multidisciplinary
Sidhartha Jandhyala, Austin Van Namen, Catalina-Paula Spatarelu, Geoffrey P. Luke
Summary: In this study, a new strategy was demonstrated to synthesize antibody-conjugated perfluorohexane nanodroplet ultrasound contrast agents that targeted cells overexpressing the epidermal growth factor receptor. The developed nanodroplets showed a significantly higher increase in ultrasound amplitude compared to non-targeted nanodroplets, indicating their potential for molecular imaging cancer diagnostics.
Review
Chemistry, Physical
Phillip G. Durham, Paul A. Dayton
Summary: Low-boiling point phase change contrast agents have enhanced medical ultrasound imaging and therapy, offering new possibilities and a wide range of potential applications in the field.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Review
Acoustics
Ranran Guo, Na Xu, Ying Liu, Guixia Ling, Jia Yu, Peng Zhang
Summary: PFC NDs are promising in tumor theranostics due to their unique properties, including tumor ablation, anti-vascular therapy, drug release, and overcoming tumor hypoxia. They can be transformed into microbubbles for imaging and exhibit high oxygen solubility.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Acoustics
Catalina-Paula Spatarelu, Sidhartha Jandhyala, Geoffrey P. Luke
Summary: Phase-changing nanodroplets are nanometric sized constructs that can be vaporized via external stimuli to generate visible bubbles in ultrasound. Our study develops a perfluoropentane core nanodroplet that can load and release paclitaxel and doxorubicin in response to an acoustic trigger. We investigate their loading, release, and biological effects on a breast cancer mouse model, showing enhanced drug-delivery effect and delayed tumor growth rate. Overall, phase-changing nanodroplets are a useful platform for on-demand delivery of drug combinations.
Review
Chemistry, Multidisciplinary
Weiqi Zhang, Yuhong Shi, Shazwan Abd Shukor, Aaran Vijayakumaran, Stavros Vlatakis, Michael Wright, Maya Thanou
Summary: Nanodroplets, as emerging phase-changing sonoresponsive materials, have gained significant attention in the field of biomedical applications. Their unique response to ultrasound, particularly cavitation through acoustic droplet vaporization (ADV), has been found to promote drug delivery into deeper tissues where tumors are located. This review summarizes the commonly used materials and preparation methods of nanodroplets. Moreover, it provides examples of the variable chemical components in nanodroplets that are linked to their efficiency as ultrasound-multimodal imaging agents and drug delivery monitors.
Review
Optics
Heechul Yoon
Summary: Laser-activated perfluorocarbon nanodroplets have the potential to provide high contrast in ultrasound and photoacoustic imaging, and can be used for various imaging approaches as well as therapeutic applications such as drug delivery and photothermal therapy. They also demonstrated blood barrier opening for neurological applications.
Article
Acoustics
Marvin Xavierselvan, Jason Cook, Jeanne Duong, Nashielli Diaz, Kimberly Homan, Srivalleesha Mallidi
Summary: The research presented a unique theranostic approach using perfluorocarbon nanodroplets as a triple carrier for oxygen, photosensitizer, and indocyanine green to enhance image-guided PDT. This approach effectively addresses hypoxia in solid tumors, improving treatment outcomes by delivering sufficient photosensitizer for ROS generation. The in vivo studies showed higher treatment efficacy compared to a clinically available formulation, demonstrating its substantial potential for patient-specific photodynamic therapy-based treatments.
Article
Acoustics
Austin Van Namen, Sidhartha Jandhyala, Tomas Jordan, Geoffrey P. Luke
Summary: Superheated perfluorocarbon nanodroplets are emerging ultrasound imaging contrast agents with biocompatible components and unique phase-change dynamics. They provide high contrast ultrasound images by undergoing a liquid-to-gas phase change upon exposure to a high-intensity pulse. However, their single-use limitation has been addressed by using a perfluorohexane core that allows the microbubbles to recondense back into their stable form, overcoming this drawback.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Acoustics
Yang Cao, Diego S. Dumani, Kristina A. Hallam, Stanislav Y. Emelianov, Haitao Ran
Summary: Optical-responsive nanodroplets are investigated as a new mode of remotely controlled drug delivery. NIR-absorber-loaded perfluorocarbon nanodroplets can be converted into gas bubbles through laser stimulation, known as optical droplet vaporization (ODV), providing a potential strategy to deliver therapeutic agents to solid tumors on demand. This study applies ultrasound and photoacoustic imaging technology to directly monitor drug-loaded nanodroplets in tissue, enabling the control of drug release and determining the optimal time point for laser activation.
Article
Chemistry, Multidisciplinary
Andrew X. X. Zhao, Yiying I. I. Zhu, Euisuk Chung, Jeehyun Lee, Samuel Morais, Heechul Yoon, Stanislav Emelianov
Summary: This study investigates the vaporization thresholds of PFCnDs (perfluorocarbon nanodroplets) through optical stimulation, and discovers a phenomenon called preconditioning. The impact of surfactants on the vaporization threshold and imaging lifetime is also studied, and a correlation between PFC critical temperatures and vaporization thresholds is observed.
Article
Acoustics
Jinwook Kim, Kathlyne Jayne B. Bautista, Ryan M. Deruiter, Leela Goel, Xiaoning Jiang, Zhen Xu, Paul A. Dayton
Summary: The thrombolysis potential of low-boiling-point perfluorocarbon phase-change nanodroplets has been found to be effective for both aged and retracted clots. In this study, the researchers compared the sonothrombolysis efficacy of nanodroplets and microbubbles on unretracted and retracted clots. The results showed that nanodroplets had better efficacy in both types of clots, with higher levels of cavitation in retracted clots. The study concluded that nanodroplet-mediated sonothrombolysis outperforms microbubble-mediated therapy, especially for retracted clots.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Review
Chemistry, Multidisciplinary
Chun-Pei Shih, Xiaofang Tang, Chiung Wen Kuo, Di-Yen Chueh, Peilin Chen
Summary: In the past two decades, there have been significant advancements in nanotechnology, specifically in biomedical applications. Biocompatibility is a critical factor in the fabrication and synthesis of nanomaterials for biomedical use, and surface engineering is commonly used to improve their specific recognition properties. This mini-review provides an overview of different approaches and design strategies for enhancing the interfaces of nanomaterials.
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Environmental
Yu-Hsiang Lee, Uyen Nu Thu Pham
Summary: In this study, a new type of nanoparticle droplets called IPLPNDs, loaded with ICG and alpha PD-L1, were developed for photoimmunotherapy of colorectal cancer. The results showed that IPLPNDs can stabilize alpha PD-L1 and generate hyperthermia and increased production of singlet oxygen, leading to enhanced cell killing upon NIR irradiation. Animal experiments further demonstrated that IPLPNDs can effectively inhibit tumor growth and enhance tumor immunogenicity. Therefore, this study is of great importance for clinical CRC treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Acoustics
Ronald H. Silverman, Raksha Urs, Mark Burgess, Jeffrey A. Ketterling, Gulgun Tezel
Summary: Elevated intraocular pressure is a major risk factor for glaucoma progression, and introducing perfluorocarbon nanodroplets into the eye may help increase permeability in the aqueous outflow track, potentially offering a treatment for the condition.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
