Exploring the Interaction of SV2A with Racetams Using Homology Modelling, Molecular Dynamics and Site-Directed Mutagenesis

Expression of SV2 isoforms during rodent brain development

(2013) Julie Crèvecœur et al.   BMC NEUROSCIENCE

Modulation of the conformational state of the SV2A protein by an allosteric mechanism as evidenced by ligand binding assays

(2013) V Daniels et al.   BRITISH JOURNAL OF PHARMACOLOGY

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Combining modelling and mutagenesis studies of synaptic vesicle protein 2A to identify a series of residues involved in racetam binding

(2012) Jiye Shi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lactose Permease and the Alternating Access Mechanism

(2011) Irina Smirnova et al.   BIOCHEMISTRY

Monotherapy for partial epilepsy: focus on levetiracetam

(2011) Antonio Gambardella   Neuropsychiatric Disease and Treatment

SV2 regulates neurotransmitter release via multiple mechanisms

(2010) Amy Nowack et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Toward the estimation of the absolute quality of individual protein structure models

(2010) Pascal Benkert et al.   BIOINFORMATICS

g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation

(2010) Maarten G. Wolf et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structure of a fucose transporter in an outward-open conformation

(2010) Shangyu Dang et al.   NATURE

SV2 Acts via Presynaptic Calcium to Regulate Neurotransmitter Release

(2010) Qun-Fang Wan et al.   NEURON

Down-regulation Synaptic Vesicle Protein 2A in the Anterior Temporal Neocortex of Patients with Intractable Epilepsy

(2009) Guibo Feng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis

(2009) W.-P. Chang et al.   JOURNAL OF NEUROSCIENCE

SVOP Is a Nucleotide Binding Protein

(2009) Jia Yao et al.   PLoS One

QMEANclust: estimation of protein model quality by combining a composite scoring function with structural density information

(2009) Pascal Benkert et al.   BMC STRUCTURAL BIOLOGY

Visualization of SV2A conformations in situ by the use of Protein Tomography

(2008) Berkley A. Lynch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy

(2008) Erwin A. van Vliet et al.   EPILEPSIA

Synaptic Vesicle Protein 2 Binds Adenine Nucleotides

(2008) Jia Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

The Jpred 3 secondary structure prediction server

(2008) C. Cole et al.   NUCLEIC ACIDS RESEARCH