Journal
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
Volume 130, Issue 5, Pages 3271-3281Publisher
ACOUSTICAL SOC AMER AMER INST PHYSICS
DOI: 10.1121/1.3626155
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A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3626155]
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