Article
Multidisciplinary Sciences
Pierre Bourgeois, E. Peters, A. Van Mieghem, A. Vrancken, G. Giacalone, A. Zeltzer
Summary: Facial edemas not caused by head and neck cancer treatment are uncommon. A retrospective analysis of lymphoscintigraphic and SPECT-CT investigations in patients with such edema revealed four main lymphatic pathways and the potential for assessing and diagnosing facial lymphedema through lymphoscintigraphy.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Arin K. Greene, Christopher L. Sudduth
Summary: This study found significant differences in BMI and cellulitis history between patients with obesity-induced lymphedema and obesity without lymphedema, while patients with lipedema were associated with BMI. Patients with higher BMI were more likely to develop lower extremity lymphedema, and severely obese patients needed to lose weight before considering surgical treatment.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hye Ok Kim, Kyong-Je Woo, Bom Sahn Kim, Seo Young Kang, Byung Seok Moon, Hai-Jeon Yoon
Summary: This study evaluated the utility of lymphoscintigraphy in predicting outcomes of lymphaticovenous anastomosis (LVA) for extremity lymphedema. The results showed that the extent of dermal backflow and lymphatic flow patterns were significantly associated with clinical outcomes after LVA surgery. Furthermore, dermal backflow and lymphatic flow patterns were identified as independent predictors of circumferential reduction rate after LVA surgery for extremity lymphedema.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jorge A. Castorena-Gonzalez
Summary: Research has established a two-way connection between obesity and lymphatic dysfunction, indicating that obesity may lead to lymphedema, with lymphatic valve dysfunction potentially being a critical component of obesity-induced lymphedema.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Christopher L. Sudduth, Arin K. Greene
Summary: Obesity-induced lymphedema (OIL) is a secondary lymphedema that may occur once an individual's BMI exceeds 40, with patients also at risk of developing massive localized lymphedema (MLL). The relationship between obesity and lymphedema is complex, with weight loss being the fundamental treatment for OIL.
ADVANCES IN WOUND CARE
(2022)
Article
Medicine, General & Internal
Sue Pavord, Marie Scully, Beverley J. Hunt, William Lester, Catherine Bagot, Brian Craven, Alex Rampotas, Gareth Ambler, Mike Makris
Summary: Phenotypes of VITT were defined in 220 patients in the United Kingdom who presented a median of 14 days after the first ChAdOx1 nCoV-19 vaccination. Half had cerebral venous sinus thrombosis, a third of whom also had intracranial hemorrhage. Mortality was 22%. Intravenous immune globulin may reverse VITT.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rachelle Crescenzi, Paula M. C. Donahue, Maria Garza, Niral J. Patel, Chelsea Lee, Kelsey Guerreso, Greg Hall, Yu Luo, Sheau-Chiann Chen, Karen L. Herbst, Michael Pridmore, Aaron W. Aday, Joshua A. Beckman, Manus J. Donahue
Summary: 3T MR lymphangiography can distinguish lipedema from obesity or lymphedema. This study used MRI technology to identify characteristic features in patients with lipedema.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Dermatology
Laila Tsaqilah, Nadia Octavia, Risa Miliawati Nurul Hidayah, Erda Avriyanti, Hartati Purbo Dharmadji
Summary: This article presents a case report of a 52-year-old female with Elephantiasis nostras verrucosa (ENV) and provides information about her medical history and treatment. Obesity is identified as a risk factor for ENV, and acitretin is highlighted as a potential treatment option.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Braden Miller, Hunter Chalfant, Alexandra Thomas, Elizabeth Wellberg, Christina Henson, Molly W. McNally, William E. Grizzle, Ajay Jain, Lacey R. McNally
Summary: Obesity, diabetes, and inflammation increase the risk of breast cancer, with imaging-based screening being essential for early detection. Conventional imaging modalities in obese and diabetic women may lead to increased sensitivity but decreased specificity. Novel molecular imaging techniques offer potential to improve breast cancer diagnosis in these high-risk patients, but further validation in clinical practice is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Ana Maria Sanchez-Bao, Alfonso Soto-Gonzalez, Manuel Delgado-Blanco, Vanesa Balboa-Barreiro, Diego Bellido
Summary: T2DM patients have an increased risk of developing MAFLD and advanced fibrosis. Liver fibrosis is positively correlated with BMI, AC, and HOMA2-IR. Non-invasive fibrosis markers, especially the NAFLD Fibrosis score, are useful for screening.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Khairunnisa' Md Yusof, Kira Groen, Rozita Rosli, Kelly A. Avery-Kiejda
Summary: Secondary lymphedema is characterized by lymphatic fluid retention and tissue swelling, often occurring after loss, obstruction, or blockage of lymphatic vessels. MicroRNAs may play pivotal roles in regulating secondary lymphedema, potentially serving as biomarkers for diseases and providing insights into the mechanisms underlying this debilitating condition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chunjiang Wang, Yulu Zhou, Weijin Fang, Zuojun Li, Shaoli Zhao
Summary: This study explores the clinical characteristics of Kounis syndrome (KS) induced by amoxicillin. The findings show that the number of patients receiving amoxicillin treatment is slightly higher than those receiving amoxicillin-clavulanate. The main symptoms include chest pain and allergic reactions, and diagnostic evaluation reveals elevated troponin and coronary artery stenosis with thrombosis. Most patients completely recover after discontinuation of the medication.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Angelika Chachaj, Ilona Dudka, Malgorzata Jeziorek, Monika Sowicz, Agnieszka Adaszynska, Andrzej Szuba
Summary: This study aims to compare lymphoscintigraphy in women with lipedema and women with overweight/obesity. The results show that lymphatic alterations are present in both groups and are associated with weight and body composition parameters. Therefore, lymphoscintigraphy cannot distinguish between lipedema and overweight/obesity.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stanley G. Rockson
Summary: In recent years, significant advancements have been made in the research and clinical approaches to lymphedema, particularly focusing on genetics, lymphatic imaging, and lymphatic surgery. New molecular insights and the relationships between lymphedema, obesity, and other comorbidities have been explored, providing valuable information for current and future responses to patients with lymphedema.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Leah M. Schumacher, Samantha G. Farris, J. Graham Thomas, Richard B. Lipton, Jelena Pavlovic, Angeliki Vgontzas, Dale S. Bond
Summary: Obesity and migraine often coexist, and poor sleep quality is common among individuals with comorbid migraine and obesity. This study evaluated the associations between migraine characteristics and sleep quality in women with comorbid migraine and overweight/obesity. The presence of phonophobia and greater monthly migraine days were associated with poorer sleep quality. Obesity severity did not independently affect sleep quality in this population. These findings can inform further research on the migraine-sleep link and guide clinical care.
JOURNAL OF CLINICAL MEDICINE
(2023)