Journal
JOURNAL OF SYNCHROTRON RADIATION
Volume 18, Issue -, Pages 88-91Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S0909049510037076
Keywords
prostaglandin D synthase; hematopoietic; H-PGDS; crystal; microgravity; space experiment; anti-inflammation; anti-allergy; JAXA; counter-diffusion
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Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a microgravity environment on protein crystallization, especially in the case of this protein.
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