Article
Obstetrics & Gynecology
Hanna Ornes Olesen, Susanne Elisabeth Pors, Lea Bejstrup Jensen, Annika Patricia Gronning, Camilla Engel Lemser, Maria Thai Hien Nguyen Heimbuerger, Linn Salto Mamsen, Natalie Getreu, Soren Tvorup Christensen, Claus Yding Andersen, Stine Gry Kristensen
Summary: Daily administration of N-acetylcysteine (NAC) for 7-12 days post-transplantation can reduce ischemia-reperfusion injury and increase follicle survival in human ovarian xenografts. This treatment works by upregulating the antioxidant defense system and exerting anti-inflammatory and antiapoptotic effects.
HUMAN REPRODUCTION
(2021)
Article
Medicine, Research & Experimental
Oner Ulger, Gokhan Burcin Kubat, Zehra Cicek, Ertugrul Celik, Ozbeyen Atalay, Serpil Suvay, Mehmet Ozler
Summary: The study demonstrated the significant therapeutic effects of mitochondrial transplantation in treating liver damage caused by APAP toxicity. Compared to NAC application, mitochondrial transplantation showed more effective improvement in histological and functional aspects, indicating its potential as an important alternative or adjunctive treatment for liver damage.
Article
Biochemistry & Molecular Biology
Tansel Sapmaz, Kubra Sevgin, Sude Topkaraoglu, Muhammetnur Tekayev, Selman Aktas, Gulfidan Coskun, Sait Polat, Ekrem Sapmaz, Oktay Irkorucu
Summary: This study aimed to investigate the effects of melatonin, oxytetracycline, and N-acetylcysteine on ovarian follicle reserves and surface epithelium in autologous intraperitoneal ovarian transplantation in rats. The results suggested that oxytetracycline and melatonin might have more protective effects during ovarian transplantation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Viktorija Zitkute, Mindaugas Kvietkauskas, Vygante Maskoliunaite, Bettina Leber, Diana Ramasauskaite, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: The study showed that melatonin, glycine, and their combination can significantly reduce ischemia/reperfusion injury in a rat model, potentially by protecting tissue from oxidative stress and inflammation. Further clinical studies are needed to evaluate the protective effects of these substances in uterine IRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Zhiyong Guo, Qiang Zhao, Zehua Jia, Changjun Huang, Dongping Wang, Weiqiang Ju, Jian Zhang, Lu Yang, Shanzhou Huang, Maogen Chen, Xiaofeng Zhu, Anbin Hu, Yi Ma, Linwei Wu, Yinghua Chen, Ming Han, Yunhua Tang, Guodong Wang, Linhe Wang, Lifen Li, Wei Xiong, Zhiheng Zhang, Yuekun Shen, Zhaoxia Tang, Caihui Zhu, Xiaoxiang Chen, Xiaoguang Hu, Yiwen Guo, Honghui Chen, Yihao Ma, Tao Zhang, Shunwei Huang, Ping Zeng, Simei Lai, Tielong Wang, Zhitao Chen, Jinlong Gong, Jia Yu, Canhui Sun, Chang Li, Haiyi Tan, Yao Liu, Yuqi Dong, Chengjun Sun, Bing Liao, Jun Ren, Zhenhai Zhou, Schlegel Andrea, Nashan Bjorn, Changjie Cai, Fengqiu Gong, Jian Rong, Wenqi Huang, Xiangdong Guan, Pierre-Alain Clavien, Tullius G. Stefan, Jiefu Huang, Xiaoshun He
Summary: Ischemia-reperfusion injury (IRI) is a significant concern in organ transplantation, but ischemia-free organ transplantation may provide a solution by avoiding IRI and improving outcomes.
JOURNAL OF HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Norbert Nemeth, Katalin Peto, Zsuzsanna Magyar, Zoltan Klarik, Gabor Varga, Mihai Oltean, Anna Mantas, Zoltan Czigany, Rene H. Tolba
Summary: Hepatic ischemia-reperfusion injury is a complex phenomenon with multiple factors involved, and its pathomechanism has not been fully elucidated despite over thirty years of research. Blood flow properties and hemorheological factors play important roles in tissue perfusion and endothelial cell function, and interventions such as antioxidants, anti-inflammatory agents, and organ preservation techniques may provide protection against hepatic IRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yonela Ntamo, Khanyisani Ziqubu, Nireshni Chellan, Bongani B. Nkambule, Tawanda M. Nyambuya, Sithandiwe E. Mazibuko-Mbeje, Kwazikwakhe B. Gabuza, Patrick Orlando, Luca Tiano, Phiwayinkosi V. Dludla
Summary: Liver transplantation is the definitive treatment for complete liver failure, but oxidative stress and inflammation contribute to the damage caused during the procedure. N-acetyl cysteine (NAC) has been studied as a potential therapeutic drug to counteract oxidative stress and inflammation. Clinical evidence suggests that NAC can improve liver function by enhancing endogenous antioxidants and attenuating inflammation, but some studies have shown conflicting results.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Chen Liang, Kazuhiro Takahashi, Kinji Furuya, Tatsuya Oda, Nobuhiro Ohkohchi
Summary: The study found that thrombocytosis can stimulate graft regeneration, prolong survival, and not exacerbate ischemia/reperfusion injury (IRI) after partial liver transplantation. Kupffer cells play a vital role in platelet-derived regeneration.
LIVER TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Joris Blondeel, Nicholas Gilbo, Veerle Heedfeld, Tine Wylin, Louis Libbrecht, Ina Jochmans, Jacques Pirenne, Hannelie Korf, Diethard Monbaliu
Summary: During normothermic machine perfusion (NMP), livers procured after warm ischemia (WI) exhibit a distinct innate immune response compared to directly procured (DP) livers. The cytokine profile in WI livers shifts towards an anti-inflammatory phenotype during NMP and whole blood (WB) reperfusion, while pro-apoptotic signaling is stronger during NMP. WB reperfusion results in a blunted cytokine release in livers, suggesting a reconditioning effect of NMP, regardless of ischemic damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Asa Noren, Mihai Oltean, Styrbjorn Friman, Antonio Molinaro, Johan Molne, Carina Sihlbom, Gustaf Herlenius, Annika Thorsell
Summary: Acute kidney injury (AKI) is common after liver transplantation (LT) and is related to the later development of chronic kidney disease. This study found that grafts from LT recipients who develop early AKI have distinct proteomic alterations, primarily dominated by an early yet prominent activation of innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jedson R. Liggett, Jiman Kang, Suman Ranjit, Olga Rodriguez, Katrina Loh, Digvijay Patil, Yuki Cui, Anju Duttargi, Sang Nguyen, Britney He, Yichien Lee, Kesha Oza, Brett S. Frank, DongHyang Kwon, Heng-Hong Li, Bhaskar Kallakury, Andrew Libby, Moshe Levi, Simon C. Robson, Thomas M. Fishbein, Wanxing Cui, Chris Albanese, Khalid Khan, Alexander Kroemer
Summary: This study investigated the role of Type 1 Natural Killer T-cells (NKT1 cells) in hepatic ischemia-reperfusion injury (IRI) and found that hepatic steatosis exacerbates the damage. Through experiments and analysis, it was observed that a high-fat diet increases the frequency of NKT1 cells and enhances interferon-gamma expression. The study also demonstrated that oral NAC supplementation can improve liver function and glycolysis, while reducing interferon-gamma expression. Lipidomic analysis revealed that NAC downregulates the PPAR-gamma pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
George Clarke, Jingwen Mao, Yiyu Fan, Angus Hann, Amita Gupta, Anisa Nutu, Erwin Buckel, Kayani Kayani, Nicholas Murphy, Mansoor N. Bangash, Anna L. Casey, Isla Wootton, Alexander J. Lawson, Bobby V. M. Dasari, M. Thamara P. R. Perera, Hynek Mergental, Simon C. Afford
Summary: The addition of antioxidant N-acetylcysteine (NAC) in normothermic machine perfusion (NMP) can effectively limit the formation and accumulation of methaemoglobin, prolonging the duration of perfusion.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Saemann, Sevil Korkmaz-Icoz, Fabio Hoorn, Gabor Veres, Patricia Kraft, Adrian-Iustin Georgevici, Maik Brune, Yuxing Guo, Sivakkanan Loganathan, Folker Wenzel, Matthias Karck, Gabor Szabo
Summary: The study showed that using HTK-N solution for machine perfusion can improve contractility of CD-hearts, reduce oxidative and nitrosative stress, and prevent cardiomyocyte swelling and necrosis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Review
Gastroenterology & Hepatology
Jiang Liu, Kwan Man
Summary: Ischemia/reperfusion injury is an inevitable process during liver transplantation, leading to high rates of dysfunction and failure. The mechanism involves microcirculation dysfunction, hypoxia, oxidative stress, and cell death. The immune response also plays a crucial role. Studies on living donor liver transplantation have identified specific mitochondrial and metabolic dysfunction in certain types of graft injury. These findings have paved the way for new biomarkers and potential therapeutics, but further validation and clinical trials are needed. This review emphasizes the importance of the spatiotemporal microenvironment resulting from various factors in liver ischemia/reperfusion injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Ryohei Takei, Tomoharu Miyashita, Satoshi Takada, Hidehiro Tajima, Itasu Ninomiya, Hiroyuki Takamura, Sachio Fushida, Ai Harashima, Seiichi Munesue, Shintaro Yagi, Noriyuki Inaki, Tetsuo Ohta, Yasuhiko Yamamoto
Summary: Chronic inflammation plays a role in tumor development, including esophageal cancer. The study found that metformin could potentially suppress esophageal cancer by improving the immunosuppressive tumor microenvironment and immune evasion.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Tadahiro Takada, Shuji Isaji, Masahiro Yoshida, Akihiko Horiguchi, Hisami Ando, Shuichi Miyakawa, Seiki Kiriyama, Harumi Gomi, Shuntaro Mukai, Ryota Higuchi, Yuta Abe, Kohji Okamoto, Kenji Suzuki, Naoyuki Toyota, Shutaro Hori, Yuki Homma, Hiroyuki Kato, Akiko Umezawa, Jiro Hata, Dai Inoue, Motoyuki Kobayashi, Toshio Tsuyuguchi, Hirotoshi Maruo, Yusuke Kumamoto, Yukio Asano, Yuka Kondo, Satoshi Arakawa, Koji Asai, Yasuhisa Mori, Yukiko Nagamachi, Shugo Mizuno, Shintaro Yagi, Tetsuji Ohyama, Takeyuki Misawa, Keiji Sano, Takao Itoi, Nobuhiko Taniai, Michiaki Unno, Masakazu Yamamoto, Toshihiko Mayumi
Summary: This study introduced a modified Socratic method for educational seminars, focusing on a clinical scenario of moderate acute cholecystitis. By using lectures, videos, and interactive tools, participants engaged in repeated questioning and discussions, leading to a significant increase in the recognition rate of the topic. The method received high praise and is likely to be adopted by other academic societies in the future.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Correction
Gastroenterology & Hepatology
Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik-Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Mariza de Andrade, Aris Baras, Julie Horowitz, Manuel A. R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Jinyoung Byun, Younghun Han, Richard N. Sandford, Konstantinos N. Lazaridis, Christopher I. Amos, Gideon M. Hirsch, Michael F. Seldin, Pietro Invernizzi, Katherine A. Siminovitch, Xiong Ma, Minoru Nakamura, George F. Mells
JOURNAL OF HEPATOLOGY
(2022)
Article
Orthopedics
Makoto Kurimoto, Satoru Seo, Tomoaki Yoh, Hironori Shimizu, Yuki Masano, Satoshi Ogiso, Takayuki Anazawa, Takamichi Ishii, Koichiro Hata, Toshihiko Masui, Kojiro Taura, Etsuro Hatano
Summary: This report presents a case of dissecting aneurysm of the proper hepatic artery (PHA) possibly associated with the Pringle maneuver during laparoscopic hepatectomy, that was successfully treated by transcatheter arterial embolization (TAE).
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Nadja Kroeger, Zoltan Czigany, Jipin Jiang, Mamdouh Afify, Pascal Paschenda, Kazuyuki Nagai, Shintaro Yagi, Rene H. Tolba
Summary: This study investigated the effects of fibrinolysis combined with Venous Systemic Oxygen Persufflation (VSOP) on the preservation of livers retrieved from donors after circulatory death (DCD). The results showed that the combination treatment improved microvascular flow, microperfusion velocity, and portal venous flow. It also reduced enzyme release and lactate dehydrogenase levels, indicating improved organ integrity and viability. The findings suggest that SK + VSOP combination treatment may be a potential therapeutic approach for DCD in the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Koichiro Hata, Takahiro Nishio, Shoichi Kageyama, Satoshi Ogiso, Ken Fukumitsu, Motoyuki Kumagai, Hideo Kanemitsu, Kazuhiro Yamazaki, Kenji Minatoya, Etsuro Hatano
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tetsuya Tajima, Koichiro Hata, Jiro Kusakabe, Hidetaka Miyauchi, Kimiko Yurugi, Rie Hishida, Eri Ogawa, Tatsuya Okamoto, Mari Sonoda, Shoichi Kageyama, Xiangdong Zhao, Takashi Ito, Satoru Seo, Hideaki Okajima, Miki Nagao, Hironori Haga, Shinji Uemoto, Etsuro Hatano
Summary: This study shows that HLA mismatch significantly affects recipient survival and the incidence of rejection in adult liver transplantation but not in pediatric cases.
LIVER TRANSPLANTATION
(2022)
Article
Surgery
Yuji Yoshioka, Yohei Oshima, Koichiro Hata, Susumu Sato, Ryota Hamada, Tatsuya Sato, Toshimi Kaido, Fumiaki Munekage, Takashi Ito, Ryosuke Ikeguchi, Shinji Uemoto, Etsuro Hatano, Shuichi Matsuda
Summary: This study found that preoperative muscle strength and early postoperative walking were associated with early posttransplant exercise tolerance. Maintaining preoperative muscle strength and allowing for early postoperative mobilization might help enhance the recovery of physical function and facilitate the patient's social reintegration after living-donor liver transplantation (LDLT).
CLINICAL TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Siyuan Yao, Shintaro Yagi, Masaaki Hirata, Yosuke Miyachi, Eri Ogawa, Ryuji Uozumi, Takuya Sugimoto, Takashi Asahara, Shinji Uemoto, Etsuro Hatano
Summary: This prospective study investigated the changes in gut microbiota and associated intestinal environment during the early period after liver transplantation. The recipients showed dysbiosis and depletion of organic acid before transplantation, which were related to the severity of liver disease. The transplantation procedure caused minimal changes in gut microbiota and organic acid concentrations in the donors, while the recipients exhibited delayed recovery in these factors.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Takahiro Nishio, Takashi Ito, Koichiro Hata, Kojiro Taura, Etsuro Hatano
Summary: Non-B non-C chronic liver diseases, including alcoholic liver disease and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, have increased significantly worldwide. Liver transplantation is an effective treatment for hepatocellular carcinoma and decompensated liver cirrhosis. Efforts to unify the indications for eligibility of HCC patients for liver transplantation have been made in Japan, leading to the development of 5-5-500 criteria. The management of patients with various comorbidities during the peri-transplant period and risk assessment for liver transplantation are crucial for improving post-transplant outcomes.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Surgery
Masaaki Hirata, Shintaro Yagi, Takashi Ito, Yuki Masano, Shinya Okumura, Siyuan Yao, Yosuke Miyachi, Hikaru Aoki, Kaoru Katano, Etsuro Hatano
Summary: The present study describes an efficient five-step training protocol for rat liver transplantation (LT), which can be mastered within 3 months through continuous training. The training includes watching videos, performing actual operations, and achieving specific goals. Systematizing the training increases its efficiency, and determining the specific number of operations in advance helps maintain motivation.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Tetsuya Tajima, Koichiro Hata, Hironori Haga, Jiro Kusakabe, Shoichi Kageyama, Kimiko Yurugi, Rie Hishida, Xiangdong Zhao, Momoko Nishikori, Miki Nagao, Akifumi Takaori-Kondo, Shinji Uemoto, Etsuro Hatano
Summary: Antibody-mediated rejection (AMR) is a difficult-to-treat rejection that occurs after ABO blood-type incompatible (ABOi) or donor-specific antibody (DSA)-positive liver transplantation. The use of pretransplant rituximab has reduced the development of AMR, but the risk factors for AMR in the rituximab era are still unclear in both ABOi living-donor LT and preformed DSA-positive LT.
LIVER TRANSPLANTATION
(2023)
Letter
Gastroenterology & Hepatology
Tetsuya Tajima, Koichiro Hata, Jiro Kusakabe, Etsuro Hatano
LIVER TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Tetsuya Tajima, Jung-Ho Shin, Susumu Kunisawa, Noriko Sasaki, Koichiro Hata, Kiyohide Fushimi, Etsuro Hatano, Yuichi Imanaka
Summary: This study conducted a cost-effectiveness analysis of living-donor liver transplantation (LDLT) compared to conservative management (CM) for adult patients using the Japanese nationwide database. The results showed that LDLT was cost-effective for patients with Child-Pugh class C, while it was not cost-effective for patients with Child-Pugh class B.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Kosuke Tanaka, Satoshi Ogiso, Tomoaki Yoh, Ahmed Hussein Abdelhafez, Yuki Masano, Shinya Okumura, Shoichi Kageyama, Takashi Ito, Koichiro Hata, Etsuro Hatano
Summary: This study aims to explore the relationship between donor body shape and surgical outcomes of laparoscopic-assisted donor hepatectomy (LADH). The study found that thoracic depth is associated with massive blood loss in right-lobe donors, and anthropometric parameters are helpful for predicting surgical outcomes.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)