Article
Oncology
M. Nakano, R. Kuromatsu, T. Niizeki, S. Okamura, H. Iwamoto, S. Shimose, T. Shirono, Y. Noda, N. Kamachi, H. Koga, T. Torimura
Summary: The neutrophil-to-lymphocyte ratio is an independent prognostic factor for patients with advanced hepatocellular carcinoma receiving molecular-targeted agents as primary treatment, affecting survival significantly. Decreases in the neutrophil-to-lymphocyte ratio after one month of treatment are associated with longer survival among these patients.
Article
Oncology
Zhen Qu, Yun-jie Lu, Jia-Wei Feng, Yu-xiang Chen, Long-qing Shi, Jing Chen, Navin Rambaran, Yun-Fei Duan, Xiao-zhou He
Summary: This study analyzed the data of 215 patients who underwent curative resection for hepatocellular carcinoma (HCC) and found that prognostic nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) were independent prognostic factors for overall survival and recurrence-free survival. A new nomogram based on PNI and NLR may provide individualized predictions of survival and recurrence for HCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hsiang-Ling Wu, Hsien-Cheng Kuo, Chun-Cheng Li, Yu-Ming Wu, Shih-Pin Lin, Kuang-Yi Chang, Ming-Chih Hou, Mei-Yung Tsou, Yih-Giun Cherng, Jui-Tai Chen, Ying-Hsuan Tai
Summary: The study showed that the prognostic nutritional index and perioperative relative change of neutrophil-to-lymphocyte ratio can independently predict postoperative survival in patients with hepatocellular carcinoma. The combination of both markers offers better prognostic performance for overall survival. Additionally, factors like body mass index, liver cirrhosis, chronic kidney disease, and tumor diameter were significantly associated with these markers.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Oncology
Wenlong Wu, Quancheng Wang, Dandan Han, Jianhui Li, Ye Nie, Dongnan Guo, Long Yang, Kaishan Tao, Xuan Zhang, Kefeng Dou
Summary: The study confirmed that the preoperative GPR and ALR-GPR-PLR score models were independent predictors for DFS and OS in patients with HCC, and showed good performance in stratifying patients with different outcomes.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jing-Houng Wang, Yen-Yang Chen, Kwong-Ming Kee, Chih-Chi Wang, Ming-Chao Tsai, Yuan-Hung Kuo, Chao-Hung Hung, Wei-Feng Li, Hsiang-Lan Lai, Yen-Hao Chen
Summary: Atezolizumab plus bevacizumab has been approved as the first-line treatment for unresectable hepatocellular carcinoma. This study examined the efficacy and safety of this treatment in real-world clinical practice and found that it is effective and well-tolerated. In addition, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were identified as independent prognostic factors for progression-free survival (PFS).
Article
Oncology
Philip J. Johnson, Sofi Dhanaraj, Sarah Berhane, Laura Bonnett, Yuk Ting Ma
Summary: The study found that the NLR levels in HCC patients were not significantly different from CLD patients at baseline, but significantly increased close to the end of follow-up. Multivariable Cox regression analysis showed that NLR is an independent prognostic factor for survival in HCC patients, even after adjusting for HCC stage.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Jiyun Park, Jun Park, Jung Hee Shin, Young-Lyun Oh, Hyun-Ae Jung, Man-Ki Chung, Jun-Ho Choe, Yong-Chan Ahn, Sun-Wook Kim, Jae-Hoon Chung, Tae-Hyuk Kim, Jae-Myoung Noh
Summary: The study found that high NLR before and after radiotherapy was associated with poor survival in patients with anaplastic thyroid cancer (ATC), indicating the importance of host immunity in ATC patients. This suggests that this finding may provide important information for designing future investigations on the impact of immune system modulating therapy in ATC.
Article
Oncology
Hanxin Feng, Chunbo Yang, Feng Xu, Yang Zhao, Tianqiang Jin, Zeyuan Wei, Dexin Wang, Chaoliu Dai
Summary: This study compared the therapeutic efficacy of resection (RES) and microwave ablation (MWA) for hepatocellular carcinoma (HCC) within the Milan criteria. The results showed that MWA had similar survival outcomes to RES for HCC within the Milan criteria, but had a lower hospital stay and less blood loss.
Article
Oncology
Riccardo Pravisani, Federico Mocchegiani, Miriam Isola, Dario Lorenzin, Gian Luigi Adani, Vittorio Cherchi, Maria De Martino, Andrea Risaliti, Quirino Lai, Marco Vivarelli, Umberto Baccarani
Summary: Inflammatory biomarkers have prognostic value in surgically treated HCC patients, while nutritional biomarkers predict outcomes after hepatic resection but not liver transplantation. Nutritional status improves significantly in HCC patients post-liver transplant at 1 year, while inflammatory state tends to persist. Post-liver transplant PLR and NLR maintain prognostic value, while CONUT and PNI acquire it.
Article
Medicine, General & Internal
Eun Ju Cho, Su Jong Yu, Yun Bin Lee, Jeong-Hoon Lee, Yoon Jun Kim, Jung-Hwan Yoon
Summary: In this study, the researchers investigated the association between baseline inflammation-based scores and serum fibrosis markers with the prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). They found that high baseline NLR and FIB-4 levels were independent factors for disease progression and death in these patients.
Article
Gastroenterology & Hepatology
Jaekyung Cheon, Changhoon Yoo, Jung Yong Hong, Han Sang Kim, Dae-Won Lee, Myung Ah Lee, Jin Won Kim, Ilhwan Kim, Sang-Bo Oh, Jun-Eul Hwang, Hong Jae Chon, Ho Yeong Lim
Summary: This study aimed to investigate the safety and efficacy of Atezolizumab plus bevacizumab in real settings for patients with advanced hepatocellular carcinoma. The results showed that Ate/Bev demonstrated real-life efficacy and safety in Korean patients, consistent with the phase III trial results, but showed unfavorable outcomes in patients with elevated NLR.
LIVER INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xi Li, S. Ali Montazeri, Ricardo Paz-Fumagalli, Carlos A. Padula, Weiping Wang, Kabir Mody, Lewis R. Roberts, Tushar Patel, Sunil Krishnan, Beau Toskich
Summary: This study found that a decrease in lymphocyte count is common after radioembolization, but had little clinical impact. Neither pre-treatment nor post-treatment neutrophil to lymphocyte ratio (NLR) was predictive of survival in the study population. NLR ratio (NLRR) and change in NLR (Delta NLR) were independent predictors for survival in BCLC stage C disease, with positive correlations with volume of liver tissue treated and administered activity.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Xuming Zhu, Hongxing Zhou
Summary: This study evaluated the ability of neutrophil-to-lymphocyte ratio (NLR) in distinguishing cirrhotic hepatocellular carcinoma (HCC) from liver cirrhosis (LC). The results showed that NLR can distinguish LC from healthy controls (HC), but cannot distinguish cirrhotic HCC from LC.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Review
Medicine, General & Internal
Pierluigi Toniutto, Elisa Fumolo, Ezio Fornasiere, Davide Bitetto
Summary: This review discusses the current data on pretransplant criteria for liver transplantation in HCC patients exceeding the Milan Criteria, based on tumor morphological and histological characteristics validated in clinical practice. It also evaluates the role of HCC biological markers and tumor response to downstaging procedures as new tools for selecting patients with a tumor burden outside of the Milan Criteria for liver transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Kaustav P. Shah, Haocan Song, Fei Ye, Douglas B. Johnson
Summary: In patients with BRAF(V600)-mutated melanoma, the number of distinct tumor sites at the initiation of targeted therapy is associated with survival, while serum lactate dehydrogenase values and the absolute lymphocyte count to absolute neutrophil count ratio are strong predictors of prognosis. Using both of these markers can help stratify prognosis for patients with metastatic melanoma receiving targeted therapy.
Article
Food Science & Technology
Fei Yu, Cong Chen, Shuna Chen, Kaixi Wang, Haitao Huang, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: During the processing of black tea, the content of organic acids shows different trends in withering and rolling stages, which are regulated by various enzymes. This study provides insights into the dynamic changes and regulatory mechanisms of organic acids in black tea production.
Article
Food Science & Technology
Hyunuk Kang, Hui Zhou, Yushan Ye, Jiangfan Yang, Zhonghua Liu, Puming He, Bo Li, Yuanyuan Wu, Yaomin Wang, Youying Tu
Summary: Tieguanyin tea extracts have positive effects on the cognitive ability and neuroprotection of APP/PS1 mice by alleviating inflammation and improving antioxidant capacity.
Article
Biochemistry & Molecular Biology
Cong Chen, Huanqing Zhu, Jiaxin Kang, Hasitha Kalhari Warusawitharana, Shuna Chen, Kaixi Wang, Fei Yu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: This study provides a comprehensive understanding of saponin biosynthesis and accumulation in tea plants, identifying key enzymes and transcription factors involved in saponin biosynthesis through analysis of tea flower and seed samples. The mevalonate pathway, along with HMGS, MVD, IDI enzymes, were found to be responsible for saponin accumulation, highlighting the potential regulatory role of ten transcription factors in tea plant saponin biosynthesis.
Article
Biochemistry & Molecular Biology
Youying Tu, Hyunuk Kang, Eunhye Kim, Jiangfan Yang, Puming He, Yuanyuan Wu, Bo Li, Xiaobo Liu, Junsheng Liu
Summary: The study found that Tieguanyin tea extracts could alter fecal metabolites in AD mice, with Tgy-C being the most effective. Metabolomics analysis showed Tgy-C's reduction effect on fecal metabolites in AD mice, which may involve pathways like protein digestion and absorption, and amino acid biosynthesis.
Article
Environmental Sciences
Ang Li, Bo Li, Bin Lu, Dong Yang, Suxia Hou, Xiaolong Song
Summary: The generation estimation of retired mobile phones in China is calculated based on sales data and subscriber numbers. The study also analyzes the mass and material characteristics of retired mobile phones, and proposes policy implications for improving the sustainable management system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Applied
Cong Chen, Fei Yu, Xinli Wen, Shuna Chen, Kaixi Wang, Feiquan Wang, Jianming Zhang, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: This study reveals the formation and mechanisms of (E)-2-hexenal during tea processing, and identifies the role of CsHI in this process. Additionally, it shows that abiotic stresses can regulate the proportions of (Z)-3-hexenal and (E)-2-hexenal in torn tea leaves by modulating CsHI expression levels. The findings of this study are important for the development of tea flavor and plant defense against abiotic stresses.
Editorial Material
Ecology
Ming Nie, Wenwen Liu, Steven C. Pennings, Bo Li
Article
Nutrition & Dietetics
Huanqing Zhu, Kaixi Wang, Shuna Chen, Jiaxin Kang, Na Guo, Hongbo Chen, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: Tea seed saponins can stimulate GIP expression via SGLT1 and TGR5, and have potential effects on improving metabolism and related diseases.
Letter
Multidisciplinary Sciences
Xinxin Wang, Xiangming Xiao, Qiang He, Xi Zhang, Jihua Wu, Bo Li
Review
Biochemistry & Molecular Biology
Shuna Chen, Jiaxin Kang, Huanqing Zhu, Kaixi Wang, Ziyi Han, Leyu Wang, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: L-theanine is the main amino acid in tea leaves and has both flavor and health benefits. Its immunomodulatory effects, particularly on reducing immunosuppression and improving immunity, have been studied in clinical and epidemiological research. Numerous studies on cells and animals have also shown that theanine plays a role in regulating inflammation, nerve damage, the intestinal tract, and tumors by regulating certain cellular functions.
Review
Biochemistry & Molecular Biology
Hongbo Chen, Fei Yu, Jiaxin Kang, Qiao Li, Hasitha Kalhari Warusawitharana, Bo Li
Summary: The composition and contents of organic acids vary in different types of tea. They play important roles in the metabolism of tea plants, nutrient absorption and growth regulation, as well as the aroma and taste quality of tea. However, the research on organic acids in tea is still limited. This article reviewed the progress made in studying organic acids in tea, including analysis methods, physiological functions, composition and influencing factors, sensory contributions, as well as health benefits like antioxidation and digestion promotion. It aims to provide references for further research on organic acids in tea.
Article
Plant Sciences
Yuanfei Pan, Mu Liu, Alejandro Sosa, Bo Li, Mang Shi, Xiaoyun Pan
Summary: This study investigates the metacommunities of endophytic fungi in the leaves of an invasive plant and finds that the structure of these fungal communities is influenced by multiple spatial scales and different drivers. These findings are important for understanding the global patterns of fungal diversity.
Article
Computer Science, Interdisciplinary Applications
Xian Song, Bo Li, Pengyu Wang, Yizhao Zhou, Jian Wang, Yaqun Wang, Chengbing Fang, Meiyuan Jin
Summary: This article fabricated a flexible piezoelectric sensor to gather data for the pulse-taking procedure and used it to recognize whether a woman is pregnant. The pulse signal was processed by GoogleNet and achieved a 90.48% correction rate, which solidified the objectivity of pulse diagnosis and raised the digitalization level of TCM.
ENGINEERING REPORTS
(2023)
Article
Remote Sensing
Xi Zhang, Xiangming Xiao, Xinxin Wang, Xiao Xu, Shiyun Qiu, Lianghao Pan, Jun Ma, Ruiting Ju, Jihua Wu, Bo Li
Summary: Biological invasions, especially by Spartina alterniflora, are significantly impacting the structure and functions of coastal ecosystems in China. Urgent efforts to control the spread of this invasive species are hindered by the lack of time-series data. By using satellite images, this study successfully generated annual maps of Spartina saltmarshes from 1985 to 2020, revealing a continuous expansion of Spartina along the coast. The invasion history and frequency of changes were found to be influenced by latitude, with low latitudes experiencing longer and more frequent invasions. Human interventions have contributed to the decline in certain areas, but natural spread remains the primary driver of its extensive invasion.
INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION
(2023)
Article
Instruments & Instrumentation
W. Liu, Z. Zhang, J. Wu, T. Ma, Y. Zhang, Y. M. Hu, Y. Q. Zhang, Y. Y. Huang, H. X. Jiang, X. K. Jiang, D. Y. Chen
Summary: This article focuses on the pre-launch characterization of the HXI spectrometer, including detection efficiency, energy resolution, and energy to ADC channel relationship. The characterization results show that the HXI spectrometer meets the performance requirements and is capable of performing on-orbit observation activities.
JOURNAL OF INSTRUMENTATION
(2022)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)