Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Rumysa Saleem Khan, Anjum Hamid Rather, Taha Umair Wani, Muheeb Rafiq, Sami-Ullah Rather, Arvind H. Jadhav, M. Hemavathi, Muzafar A. Kanjwal, Faheem A. Sheikh
Summary: In this study, silk fibroin and silver nanoparticles were successfully coated on polyurethane fibers to enhance their biocompatibility and antibacterial activity. The treated fibers showed improved water contact angle and moisture regain. The composite materials exhibited good mineralization and antimicrobial ability, as well as enhanced cell proliferation and attachment.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Review
Cell & Tissue Engineering
Hesham Soliman, Marine Theret, Wilder Scott, Lesley Hill, Tully Michael Underhill, Boris Hinz, Fabio M. Rossi
Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.
Review
Cell Biology
Vadim I. Chechekhin, Konstantin Yu. Kulebyakin, Romesh I. Kokaev, Pyotr A. Tyurin-Kuzmin
Summary: Adipose tissue relies on the regulation of multipotent mesenchymal stromal cells (MSCs), which serve as both precursors for new adipocytes and key paracrine regulators of adipose tissue homeostasis. The activity of MSCs is tightly controlled, regulating aspects such as proliferation, differentiation, and signal molecule production through modulation of hormonal sensitivity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz, Marc G. Jeschke
Summary: This study suggests that for full-thickness burn excised wound regeneration, the optimal cell dosage range is the low dose range of 200 to 40,000 cells/cm(2), rather than the traditional belief that more cells lead to better healing outcomes.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Engineering, Biomedical
Deboki Naskar, Sunaina Sapru, Ananta K. Ghosh, Rui L. Reis, Tuli Dey, Subhas C. Kundu
Summary: Silkworm silk and its extracted silk proteins exhibit excellent biocompatibility and biodegradability, making them promising for tissue engineering and regenerative medicine applications. Wild nonmulberry silkworm species also show potential as biomaterials with unique properties and functions.
BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Marina Bekic, Marina Radanovic, Jelena Dokic, Sergej Tomic, Mile Erakovic, Dusan Radojevic, Milos Duka, Dejan Markovic, Milan Markovic, Bashkim Ismaili, Dejan Bokonjic, Miodrag Colic
Summary: Gingiva-derived mesenchymal stromal cells play a significant role in periodontitis. This study investigated how the key etiological agent, P. gingivalis, affects the function and expression of healthy and periodontitis gingiva-derived mesenchymal stromal cells. The results revealed differences in proliferation, immunosuppressive potential, and gene expression between the two cell types, highlighting the impact of P. gingivalis on periodontitis-related inflammation and immune regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Promita Bhattacharjee, Mark Ahearne
Summary: There is a need to develop tissue engineering methods to address the shortage of donor corneas for transplantation. A novel approach using free-radical polymerization to fabricate three-dimensional hydrogels for corneal stromal tissue regeneration was investigated. The hydrogels showed rapid gelation, good porosity, enhanced cellular adhesion and proliferation, and no cytotoxicity. This study provides an initial step towards developing clinically applicable ocular implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell & Tissue Engineering
Diego Noe Rodriguez-Sanchez, Giovana Boff Araujo Pinto, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira, Ana Livia Carvalho Bovolato, Marcio de Carvalho, Jorge Vicente Lopes da Silva, Janaina de Andrea Dernowsek, Marjorie Golim, Benedito Barraviera, Rui Seabra Ferreira, Elenice Deffune, Mathues Bertanha, Rogerio Martins Amorim
Summary: The study demonstrated that the combination of 3D-printed PLC-NGCs with AdMSCs derived from adipose tissue exerted neuroregenerative effects on rats with sciatic nerve injury, improving motor function and nerve conduction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Article
Cell Biology
Janina Burk, Michaela Melzer, Alina Hagen, Katrin Susanne Lips, Katja Trinkaus, Ariane Nimptsch, Jenny Leopold
Summary: This study investigated the applicability of lipid phenotyping for MSC characterization and discrimination, finding differences in phospholipid species diversity between MSC from different species, and identified potentially suitable lipid markers across culture conditions. Phospholipid profiling could be a promising approach for MSC characterization, allowing for some heterogeneity within MSC while still achieving clear discrimination from fibroblasts.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Rose Triantafillia Psaroudis, Urvashi Singh, Maximilien Lora, Peter Jeon, Abigail Boursiquot, Ursula Stochaj, David Langlais, Ines Colmegna
Summary: This study identifies DPP4 gene expression and CD26 protein abundance as markers of replicative senescence in MSC(AT). MSCs with high CD26 expression have reduced immunopotency, and senolytic treatment can decrease the frequency of CD26(high) MSCs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alice Blufstein, Christian Behm, Barbara Kubin, Johannes Gahn, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov
Summary: This study reveals the immunomodulatory properties of GMSCs towards PMNs, with IL-1 beta enhancing their anti-apoptotic effects. However, GMSCs did not affect the ROS production of PMNs.
Article
Biochemistry & Molecular Biology
Miodrag Colic, Natasa Miljus, Jelena Dokic, Marina Bekic, Aleksandra Krivokuca, Sergej Tomic, Dusan Radojevic, Marina Radanovic, Mile Erakovic, Bashkim Ismaili, Ranko Skrbic
Summary: This study tested the effect of pomegranate peel extract (PoPEx) on gingiva-derived mesenchymal stromal cells (GMSCs) and found that it has a complex modulatory effect on gene expression, depending on the concentration, cell type, and inflammatory stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Melina Ramallo, Irene Carreras-Sanchez, Alba Lopez-Fernandez, Roberto Velez, Marius Aguirre, Sara Feldman, Joaquim Vives
Summary: Compliance with regulations requires testing candidate therapies in translational animal models before human use. Challenges arise when the drug contains cells due to potential xenogeneic responses. Procedures have been developed to isolate species-specific cell types for preclinical studies, addressing pharmacodynamics, pharmacokinetics, and toxicology.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kyungdo Han, Jun-Beom Park
Summary: The study suggests an association between oral health, depicted by number of natural teeth, and the increased risk of kidney diseases. The risk of end-stage renal disease was found to be higher with lower number of natural teeth and longer follow-up periods. Factors such as age, body mass index, and smoking status were also significantly associated with this relationship.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Hyunjin Lee, Youngmin Song, Yoon-Hee Park, Md. Salah Uddin, Jun-Beom Park
Summary: The study investigated the effects of Cuminum cyminum extract on the cellular viability and osteogenic differentiation of human mesenchymal stem cells. The results showed that the extract enhanced the expressions of specific genes related to osteogenesis, indicating a potential beneficial impact on stem cell mineralization. Nonetheless, no significant changes were observed in cell morphology and alkaline phosphatase activity.
MEDICINA-LITHUANIA
(2021)
Article
Engineering, Biomedical
Shobha Regmi, Yoojin Seo, Ji-Su Ahn, Shiva Pathak, Suman Acharya, Tiep Tien Nguyen, Simmyung Yook, Jong-Hyuk Sung, Jun-Beom Park, Jong Oh Kim, Chul Soon Young, Hyung-Sik Kim, Jee-Heon Jeong
Summary: The tissue repairing capacity and immunomodulatory effects of mesenchymal stem cells (MSCs) have been utilized for treating various inflammatory disorders, but low survival rates after transplantation limit their clinical potential; a novel strategy involving heterospheroids (HS) comprising MSCs and quercetin-loaded microspheres (MSCHS) was designed to improve the microenvironment of MSCs and achieve better therapeutic outcomes in a murine model of colitis. MSCHS displayed enhanced survival capacity and better therapeutic outcomes compared to 3D-cultured MSCs (MSC3D), partially due to their superior PGE2 secretion in promoting tissue repair.
Article
Medicine, Research & Experimental
Sae Kyung Min, Minji Kim, Jun-Beom Park
Summary: This study demonstrated that the application of IGF-2 increased alkaline phosphatase activity, Alizarin red staining, and Runx2 and Col1 expression of stem cell spheroids.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Dermatology
Ju Hee Han, Jin Woo Park, Kyung Do Han, Jun Beom Park, Miri Kim, Ji Hyun Lee
Summary: The study found that patients with periodontitis have a significantly higher risk of developing psoriasis compared to those without periodontitis. Non-smokers with periodontitis had an 11% increase in risk of psoriasis, while smokers with periodontitis had a 26.5% increase in risk of psoriasis compared to non-smokers without periodontitis.
Article
Multidisciplinary Sciences
Eunkyung Jeong, Jun-Beom Park, Yong-Gyu Park
Summary: The study examined the association between periodontitis and incident Parkinson's disease in the South Korean population. The presence of periodontitis was positively correlated with the incidence probability of Parkinson's disease, with the highest risk seen in individuals with both periodontitis and metabolic syndrome. Adjusting for confounding factors suggested a weak association between periodontitis and Parkinson's disease.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Abdullah Zaki Alnahash, Young-Min Song, Sae-Kyung Min, Hyun-Jin Lee, Min-Ji Kim, Yoon-Hee Park, Je-Uk Park, Jun-Beom Park
Summary: The study showed that the addition of CTGF can enhance osteogenic differentiation of stem cell spheroids, leading to a significant increase in the mRNA expression levels of RUNX2, BSP, OCN, and COL1A1.
APPLIED SCIENCES-BASEL
(2021)
Article
Nutrition & Dietetics
Im-kyung Kim, Yun Sun Lee, Hyung Sun Kim, So Young Jun, Seung Eun Oh, Hyung Mi Kim, Jin Hong Lim, Young-Tae Lee, Ju Young Park, Minchul Seo, Mi-Ae Kim, Jae-Sam Hwang, Joon Seong Park
Summary: The clinical application of a protein-enhanced diet using mealworms improved the activity of immune cells in patients undergoing hepato-pancreato-biliary surgeries, but did not significantly enhance their nutritional status.
Article
Medicine, Research & Experimental
Young-Min Song, Hyun-Jin Lee, Sae-Kyung Min, Yoon-Hee Park, Jae-Kwen Oh, Ji-Youn Kim, Jun-Beom Park
Summary: The present study aimed to investigate the effects of noni extract on the cellular morphology, viability, and osteogenic differentiation of stem cells. The results showed that noni extract enhanced cellular viability and osteogenic differentiation without significant morphological changes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
JaeHyung Lim, Ji Eun Lee, Chang-Joo Park, Jun-Beom Park
Summary: This study found that commercially available mouthwashes, regardless of their ingredients and treatment time, can alter the morphology of osteoblast-like cells and decrease their viability.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Young-Min Song, Kyung-Hwan Na, Hyun-Jin Lee, Jun-Beom Park
Summary: This study aimed to evaluate the effects of transforming growth factor-beta on the differentiation and mRNA expression of organoids made out of human mesenchymal stem cells. The results showed that transforming growth factor-beta 1 increased the differentiation of cell organoids and increased alkaline phosphatase activity and COL1A1 mRNA expression without affecting cell viability.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Jimin Kim, Seul Ki Lee, Minyoung Jung, Seon-Yeong Jeong, Haedeun You, Ji-Yeon Won, Sang-Deok Han, Hye Jin Cho, Somi Park, Joonghoon Park, Tae Min Kim, Soo Kim
Summary: IFN-gamma-iMSC-EVs can improve symptoms of atopic dermatitis (AD), suppress inflammation, and restore skin barrier function.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Hyun-Jin Lee, Young-Min Song, Seunghoon Baek, Yoon-Hee Park, Jun-Beom Park
Summary: The study observed the effects of vitamin D on osteogenic differentiation and mineralization of human mesenchymal stem cells, finding that vitamin D could enhance the osteogenicity of stem cell spheroids. Alkaline phosphatase activity and gene expression levels like RUNX2 were increased with the addition of vitamin D, while no significant changes were observed in cell viability and spheroid diameter.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, General & Internal
Hyun-Jin Lee, Hyuna Lee, Chae-Bin Na, In-Seok Song, Jae-Jun Ryu, Jun-Beom Park
Summary: This study investigated the effects of age and sex on the cellular viability and osteogenic potential of human bone marrow-derived mesenchymal stem cells (BMSCs) cultured in osteogenic media. Results showed no significant differences in cell viability, stem cell marker expression, VEGF secretion, or osteogenic differentiation potential among different age groups or between males and females.BMSCs exhibited no age-related decreases in cellular viability or osteogenic differentiation potential.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, General & Internal
Jong-Ho Lee, Young-Min Song, Sae-Kyung Min, Hyun-Jin Lee, Hye-Lim Lee, Min-Ji Kim, Yoon-Hee Park, Je-Uk Park, Jun-Beom Park
Summary: The study demonstrates that NELL-1 promotes osteogenic differentiation of stem cell spheroids, significantly increasing alkaline phosphatase activity and anthraquinone dye staining. Different concentrations of NELL-1 did not affect spheroid morphology and cell viability.
MEDICINA-LITHUANIA
(2021)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)