Article
Cell Biology
Ping Xue, Guopei Zhang, Hongchao Zhang, Su Cui, Liang Zhang, Tao Yu, Mingyang Xiao, Liuli Li, Xiaobo Lu
Summary: Platinum-based chemotherapy is commonly used for treating non-small cell lung cancer (NSCLC), but drug resistance remains a significant challenge. This study investigated the association between polymorphisms in DNA repair genes and the efficacy of platinum-based chemotherapy in NSCLC patients. The researchers found that a specific polymorphism (rs3212986) in the ERCC1 gene was associated with overall survival and chemosensitivity to platinum-based chemotherapy. This suggests that ERCC1 rs3212986 may serve as a predictive biomarker for NSCLC patients receiving platinum-based chemotherapy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
M. Ganzinelli, H. Linardou, M. F. Alvisi, E. Caiola, G. Lo Russo, F. L. Cecere, A. C. Bettini, A. Psyrri, M. Milella, E. Rulli, A. Fabbri, M. De Maglie, P. Romanelli, S. Murray, M. Broggini, M. Marabese, M. C. Garassino
Summary: The absence of the ERCC1/XPF complex in NSCLC tumors may indicate poor outcomes in patients treated with platinum compounds. The lack of ERCC1/XPF might help identify patients who require a different therapeutic approach.
Article
Biochemistry & Molecular Biology
Sidhartha Singh, Anu Gupta, Navneet Singh, Parth Sarthi Sengupta, Saroj Kumar Panda, Siddharth Sharma
Summary: This study examines the association between MGMT and ERCC1 gene polymorphisms and the response to platinum-based drugs among lung cancer patients. The results show that these genetic variations are linked to decreased overall survival. Molecular dynamic simulation suggests that the mutated MGMT protein is more stable than the wild type, but cannot properly repair DNA, leading to lower overall survival.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Otorhinolaryngology
Daniel Z. Hong, Thaned C. C. Ong, Dhayan P. Timbadia, Hui T. A. Tan, Eunice D. Kwa, Wan Q. Chong, Boon C. Goh, Woei S. Loh, Kwok S. Loh, Ene C. Tan, Joshua K. Tay
Summary: The objective of this meta-analysis is to evaluate the impact of genetic polymorphisms on platinum-based chemotherapy-induced ototoxicity. The study identified several polymorphisms that are associated with ototoxic or otoprotective effects in patients undergoing platinum-based chemotherapy. These findings highlight the potential for personalized care through polygenic screening and cumulative risk evaluation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Pharmacology & Pharmacy
Yi-Xin Chen, Juan Chen, Ji-Ye Yin, Hong-Hao Zhou, Bai-Mei He, Zhao-Qian Liu
Summary: This study investigated the association between non-coding RNA polymorphisms and the prognosis of lung cancer patients undergoing platinum-based chemotherapy. Specific polymorphisms in ANRIL and miR-146A genes were found to be significantly associated with patient survival outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Corine de Jong, Gerarda J. M. Herder, Simone W. A. van Haarlem, Femke S. van der Meer, Anne S. R. van Lindert, Alexandra ten Heuvel, Jan Brouwer, Toine C. G. Egberts, Vera H. M. Deneer
Summary: This study investigated the genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN) in non-small cell lung cancer (NSCLC) patients. It revealed that the GG genotype of TRPV1 gene (rs879207) is associated with an increased risk of severe neuropathy. Additionally, concomitant use of paclitaxel and GG genotype also showed a significant association with severe CIPN.
Article
Biotechnology & Applied Microbiology
Parul Sharma, Navneet Singh, Siddharth Sharma
Summary: This study assessed the impact of ABC transporter gene variants on the prognosis and clinical outcomes of lung cancer patients. The results showed that certain gene variants were associated with poor survival outcomes, suggesting that genotype testing is essential for predicting prognosis in lung cancer patients.
JOURNAL OF GENE MEDICINE
(2023)
Article
Pathology
Weiguang Gu, Wenya Zhuang, Mengxia Zhuang, Minhong He, Zhihua Li
Summary: DDR gene mutations are associated with tumor metastasis, TMB, and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients. Specifically, DDR gene mutations are negatively correlated with patient survival rate and disease control rate.
DIAGNOSTIC PATHOLOGY
(2023)
Review
Reproductive Biology
Yuqiang Zhang, Sufen Cao, Chunyu Zhuang, Jiacheng Chen, Xiaojing Chen, Hong Sun, Shengying Lin, Bailang Lin
Summary: The ERCC1 rs11615 polymorphism is associated with chemosensitivity in patients with ovarian cancer, especially in the Asian population, with statistically significant genotypes in all models in the Asian population but not in the Caucasian population.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Jonathan E. Rosenberg, Se Hoon Park, Vadim Kozlov, Tu V. Dao, Daniel Castellano, Jian-Ri Li, Som D. Mukherjee, Kathryn Howells, Hannah Dry, Mark C. Lanasa, Ross Stewart, Dean F. Bajorin
Summary: This study evaluated the efficacy and safety of durvalumab and olaparib combination therapy in patients with metastatic urothelial carcinoma (UC). The results showed that there was no significant difference in progression-free survival and overall survival between the combination therapy group and the placebo group. However, secondary analysis results suggest a potential role for PARP inhibition in patients with UC harboring HRRm.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Aristotelis Bamias, Konstantinos Koutsoukos, Nikos Gavalas, Roubini Zakopoulou, Kimon Tzannis, Nikos Dedes, Anna Boulouta, Charalampos Fragkoulis, Eythymios Kostouros, Athanasios Dellis, Iraklis Mitsogiannis, Ioannis Adamakis, Ioannis Anastasiou, Andreas Skolarikos, Athanasios Papatsoris, Konstantinos Stravodimos, Nikolaos Ferakis, Stamatina Pagoni, Konstantinos Ntoumas, Dionysios Mitropoulos, Charalambos Deliveliotis, Constantinos A. Constantinides, Meletios A. Dimopoulos
Summary: The ERCC1 19007 C>T polymorphism was not associated with survival outcomes in patients with advanced urothelial cancer after platinum-based chemotherapy, but interacted significantly with the use of modern immunotherapy, showing different prognostic significance based on treatment modalities.
Article
Medicine, General & Internal
Qi Xiao, Chenxue Mao, Ying Gao, Hanxue Huang, Bing Yu, Lulu Yu, Xi Li, Xiaoyuan Mao, Wei Zhang, Jiye Yin, Zhaoqian Liu
Summary: A platinum chemotherapy response prediction model was established to evaluate the efficacy of platinum-based chemotherapy in non-small cell lung cancer (NSCLC). A discovery cohort of 217 samples and a validation cohort of 216 samples were selected for genome-wide association analysis (GWAS). SNPs with p < 10(-3) and p < 10(-4) were selected for modeling. The final model includes four SNPs and two clinical factors, with an AUC of 0.726.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Tamio Okimoto, Yukari Tsubata, Ryosuke Tanino, Mika Nakao, Takamasa Hotta, Megumi Hamaguchi, Shunichi Hamaguchi, Asuka Araki, Takeshi Isobe
Summary: The study explored the relationship between ERCC1 expression levels and the efficacy of platinum-containing chemotherapy, revealing that patients with low ERCC1 expression had better disease control rates. However, inconsistencies were observed in the immunohistochemical assessment results at different time points, highlighting the need for standardized technology to evaluate ERCC1 expression.
ANTICANCER RESEARCH
(2021)
Article
Clinical Neurology
Xiao-Dong Deng, Jian-Lin Ke, Tai-Yu Chen, Qin Gao, Zhuo-Lin Zhao, Wei Zhang, Huan Liu, Ming-Liang Xiang, Li-Zhen Wang, Ying Ma, Yun Liu
Summary: In this study, the ERCC1 rs3212986 polymorphism was found to be associated with susceptibility to ischemic stroke in a Chinese Han population. The A allele of rs3212986 was found to be related to increased risk of ischemic stroke. The altered expression of the ERCC1 gene caused by the rs3212986 polymorphism may be involved in the pathophysiological process of ischemic stroke.
FRONTIERS IN NEUROLOGY
(2023)
Review
Chemistry, Multidisciplinary
Paula Alfonso-Triguero, Julia Lorenzo, Ana Paula Candiota, Carles Arus, Daniel Ruiz-Molina, Fernando Novio
Summary: Current therapies for glioblastoma and brain tumours are inefficient and face numerous challenges. Chemotherapy and radiotherapy, along with surgical resection, are currently used as standard treatments. However, these treatments have limited efficacy and patients still face a poor prognosis. To overcome these challenges, researchers have developed and tested various platinum complexes, particularly platinum (IV)-based prodrugs, with the aim of improving anticancer activity. Nanomedicines that encapsulate these platinum-based drugs, cross the blood-brain barrier, and specifically target cancer cells show promise in increasing therapeutic effectiveness and reducing side effects.
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)