Article
Materials Science, Biomaterials
Ping Huang, Zihong Li, Li Nong, Jie Cheng, Weiying Lin
Summary: Aging is a natural process characterized by the decline of physiological functions in the body's organs and tissues. Oxidative stress, caused by active nitrogen substances like ONOO-, is considered to be the main cause of aging. Detecting changes in ONOO- in aging cells is important for studying senescence. In this study, we developed a fluorescent probe FLASN based on flavonol that can detect and treat ONOO- in cells. Our results showed that FLASN can effectively detect ONOO- in cells and reduce its production stimulated by metformin. This study provides a new perspective on the role of ONOO- in senescence and the potential therapeutic effect of flavonol.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Tian Hao, Meng Qian, Yating Zhang, Qi Liu, Adam C. Midgley, Yangping Liu, Yongzhe Che, Jingli Hou, Qiang Zhao
Summary: Acute myocardial infarction is the leading cause of death worldwide. Researchers have synthesized a hydrogel that can release nitric oxide to modulate ROS/NO imbalance after ischemia/reperfusion injury, effectively alleviating cardiac damage and improving cardiac function. The hydrogel protects against oxidative stress by activating the antioxidant defense system and reducing inflammation.
Article
Nanoscience & Nanotechnology
Zhiwei Huang, Yannan Shi, Hengcai Wang, Changju Chun, Longwang Chen, Kang Wang, Zhongqiu Lu, Yingzheng Zhao, Xinze Li
Summary: This study utilized chitosan-bilirubin nanoparticles to treat gastric ulcers through anti-inflammatory and antioxidant mechanisms, demonstrating their efficacy in in vitro and in vivo studies. The findings provide a novel approach for prophylaxis against or treatment of gastric ulcers.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Peripheral Vascular Disease
Matthew J. Rossman, Rachel A. Gioscia-Ryan, Jessica R. Santos-Parker, Brian P. Ziemba, Kara L. Lubieniecki, Lawrence C. Johnson, Natalie E. Poliektov, Nina Z. Bispham, Kayla A. Woodward, Erzsebet E. Nagy, Nathan S. Bryan, Julie A. Reisz, Angelo D'Alessandro, Michel Chonchol, Amy L. Sindler, Douglas R. Seals
Summary: Inorganic nitrite supplementation improves endothelial function in older adults by increasing NO, decreasing mitochondrial reactive oxygen species/oxidative stress, and increasing mitochondrial stress resistance.
Article
Plant Sciences
Indrani Manna, Saikat Sahoo, Maumita Bandyopadhyay
Summary: Researchers have found that nickel oxide nanoparticles affect the exposed roots of Allium cepa by disrupting cell membranes and being internalized within cell organelles, leading to disturbances in cellular homeostasis and survival. This external intervention causes changes in the cellular environment, reflected in crucial biochemical profiles.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Physiology
Murilo E. Graton, Bruno H. S. H. Ferreira, Jessica A. Troiano, Simone. R. R. Potje, Gabriel. T. T. Vale, Ana Claudia M. S. Nakamune, Carlos R. Tirapelli, Francis. J. J. Miller, Valdecir. F. F. Ximenes, Cristina Antoniali
Summary: This study compared the effects of apocynin and protocatechuic acid on hypertensive rats and vascular cells. Both compounds showed antioxidant and free radical scavenging abilities, and were able to decrease oxidative stress damage. Additionally, they increased nitric oxide levels and reduced vascular constriction. Therefore, these compounds have potential therapeutic importance in the treatment of vascular diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Hui Chen, Yongxiang Qin, Jiawei Pu, Jinxing Hu, Yuezhong Wen
Summary: This study investigated the toxicity of the chiral synthetic auxin herbicide DCPP to Arabidopsis, as well as the mutual regulation of NO, H2O2, O-2, and phytohormones at the enantiomeric level. The results revealed the important role of ROS in the enantioselective effect of DCPP and the potential redistribution of phytohormones between leaves and roots.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Akihiko Taniguchi, Mitsuru Tsuge, Nobuaki Miyahara, Hirokazu Tsukahara
Summary: COPD is characterized by chronic inflammation of the airways, with oxidative stress playing a crucial role in its development and progression by influencing inflammatory responses through various pathways. Additionally, antioxidative therapy shows promise in the prevention and treatment of COPD, according to recent clinical and experimental studies.
Review
Biochemistry & Molecular Biology
Quan Gu, Qingqing Xiao, Ziping Chen, Yi Han
Summary: Melatonin acts as a multifunctional molecule in plants, particularly in protecting against abiotic stresses. It interacts with signaling molecules such as reactive oxygen species (ROS), nitric oxide (NO), and hydrogen sulfide (H2S) to modulate plant responses to abiotic stresses and enhance plant tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Wei Cai, Wenshu Wang, Hui Deng, Bin Chen, Guo Zhang, Ping Wang, Tingting Yuan, Yongsheng Zhu
Summary: This study shows that rice plants overexpressing rat neuron nitric oxide synthase (nNOS) have higher endogenous NO levels and exhibit higher tolerance to cadmium stress. The overexpression of nNOS leads to reduced cadmium accumulation in the roots and shoots and upregulation of antioxidant enzyme genes, resulting in decreased accumulation of hydrogen peroxide (H2O2) under cadmium stress. Furthermore, the overexpression of nNOS also induces the upregulation of melatonin biosynthetic genes, resulting in increased melatonin content under cadmium treatment. Overall, this study suggests that nNOS overexpression improves the cadmium tolerance of rice seedlings through reducing cadmium accumulation, enhancing antioxidant capacity, and increasing melatonin biosynthesis.
Article
Biochemistry & Molecular Biology
Miriam M. Cortese-Krott
Summary: In addition to their role as oxygen carriers, red blood cells also contribute to NO and sulfide metabolism and act as potent circulating antioxidant cells. The concept of the reactive species interactome can help understand the redox physiology of RBCs, including how reactive species are generated and detoxified, their interactions, and their targets. Hemoglobin plays a key role in the reactive species interactome within RBCs. Further research should explore how modulation of this interactome can regulate RBC biology, physiology, and their systemic effects.
Article
Plant Sciences
Julia Renata Schneider, Mariele Muller, Andressa Carlot De Bona, Geraldo Chavarria
Summary: This study aimed to investigate the combined stress effect of water deficit and xenobiotic on soybean plants, specifically in terms of nitric oxide and proline content, and to explore the potential mitigation of this stress through biostimulant treatment. Two experiments were conducted in 2017 and 2018, with varying soil water potential levels (-0.96 to -0.02 MPa and -3.09 to -0.14 MPa) and xenobiotic treatments (control, fungicide, biostimulant, and fungicide plus biostimulant). It was found that the combined stress of xenobiotic application and water deficit increased nitric oxide and proline content in soybean plants, suggesting a threshold for deleterious effects caused by oxidative stress. Additionally, biostimulant treatment showed promise in inducing defenses against severe water deficit.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Endocrinology & Metabolism
Terry C. Lairmore, Diana Diesen, Melanie Goldfarb, Mira Milas, Anita K. Ying, Jyotirmay Sharma, Bryan McIver, Richard J. Wong, Greg Randolph
ENDOCRINE PRACTICE
(2015)
Review
Surgery
Hanna Alemayehu, Matthew Clifton, Matthew Santore, Diana Diesen, Timothy Kane, Mikael Petrosyan, Ashanti Franklin, Dave Lal, Todd Ponsky, Margaret Nalugo, George W. Holcomb, Shawn D. St Peter
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2015)
Article
Surgery
Aimee K. Gardner, Diana L. Diesen, Deborah Hogg, Sergio Huerta
AMERICAN JOURNAL OF SURGERY
(2016)
Review
Pediatrics
Sara C. Fallon, Jacob C. Langer, Shawn D. St. Peter, KuoJen Tsao, Caroline M. Kellagher, Dave R. Lal, Jill S. Whitehouse, Diana L. Diesen, Michael D. Rollins, Elizabeth Pontarelli, Marcus M. Malek, Corey W. Iqbal, Jeffrey S. Upperman, Charles M. Leys, Mark L. Wulkan, Sarah J. Hill, Martin L. Blakely, Timothy D. Kane, David E. Wesson
JOURNAL OF PEDIATRIC SURGERY
(2017)
Article
Pediatrics
Elisabeth T. Tracy, Kyla M. Bennett, Melissa E. Danko, Diana L. Diesen, Tammy J. Westmoreland, Paul C. Kuo, Theodore N. Pappas, Henry E. Rice, John E. Scarborough
JOURNAL OF PEDIATRIC SURGERY
(2010)
Article
Pediatrics
Elisabeth T. Tracy, Sarah E. Mears, P. Brian Smith, Melissa E. Danko, Diana L. Diesen, Kimberley A. Fisher, Jeff C. Hoehner, Ronald N. Goldberg, C. Michael Cotten, Henry E. Rice
JOURNAL OF PEDIATRIC SURGERY
(2010)
Article
Pediatrics
Stephanie K. Bezner, Erica I. Hodgman, Diana L. Diesen, Joshua T. Clayton, Robert K. Minkes, Jacob C. Langer, Li Ern Chen
JOURNAL OF PEDIATRIC SURGERY
(2014)
Editorial Material
Pediatrics
Diana L. Diesen, Steve Megison
JOURNAL OF PEDIATRICS
(2014)
Article
Education, Scientific Disciplines
Diana L. Diesen, Loretta Erhunmwunsee, Kyla M. Bennett, Kfir Ben-David, Basil Yurcisin, Eugene P. Ceppa, Philip A. Omotosho, Alexander Perez, Aurora Pryor
JOURNAL OF SURGICAL EDUCATION
(2011)
Article
Multidisciplinary Sciences
James D. Reynolds, Kyla M. Bennett, Anthony J. Cina, Diana L. Diesen, Matthew B. Henderson, Faisal Matto, Andrew Plante, Rachel A. Williamson, Keivan Zandinejad, Ivan T. Demchenko, Douglas T. Hess, Claude A. Piantadosi, Jonathan S. Stamler
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Pediatrics
Diana L. Diesen, Michael A. Skinner
SEMINARS IN PEDIATRIC SURGERY
(2012)
Article
Surgery
Martin L. Blakely, Jon E. Tyson, Kevin P. Lally, Susan R. Hintz, Barry Eggleston, David K. Stevenson, Gail E. Besner, Abhik Das, Robin K. Ohls, William E. Truog, Leif D. Nelin, Brenda B. Poindexter, Claudia Pedroza, Michele C. Walsh, Barbara J. Stoll, Rachel Geller, Kathleen A. Kennedy, Reed A. Dimmitt, Waldemar A. Carlo, C. Michael Cotten, Abbot R. Laptook, Krisa P. Van Meurs, Kara L. Calkins, Gregory M. Sokol, Pablo J. Sanchez, Myra H. Wyckoff, Ravi M. Patel, Ivan D. Frantz, Seetha Shankaran, Carl T. D'Angio, Bradley A. Yoder, Edward F. Bell, Kristi L. Watterberg, Colin A. Martin, Carroll M. Harmon, Henry Rice, Arlet G. Kurkchubasche, Karl Sylvester, James C. Y. Dunn, Troy A. Markel, Diana L. Diesen, Amina M. Bhatia, Alan Flake, Walter J. Chwals, Rebeccah Brown, Kathryn D. Bass, Shawn D. St Peter, Christina M. Shanti, Walter Pegoli, David Skarda, Joel Shilyansky, David G. Lemon, Ricardo A. Mosquera, Myriam Peralta-Carcelen, Ricki F. Goldstein, Betty R. Vohr, Isabell B. Purdy, Abbey C. Hines, Nathalie L. Maitre, Roy J. Heyne, Sara B. DeMauro, Elisabeth C. McGowan, Kimberly Yolton, Howard W. Kilbride, Girija Natarajan, Kelley Yost, Sarah Winter, Tarah T. Colaizy, Matthew M. Laughon, Satyanarayana Lakshminrusimha, Rosemary D. Higgins
Summary: The study found that initial surgical treatment of necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP) did not result in overall differences in death or neurodevelopmental impairment (NDI) rates in premature infants. However, the impact of initial treatment varied depending on the preoperative diagnosis of NEC or IP.
Review
Pediatrics
Samuel M. Alaish, Marjorie J. Arca, Brian T. Bucher, Cathi Cooney, Diana L. Diesen, Peter F. Ehrlich, Barbara A. Gaines, Cornelia L. Griggs, Patrick J. Javid, Sanjay Krishnaswami, William Middlesworth, Cynthia L. Wong, Laura Edgar
Summary: The Milestones is an educational outcomes assessment tool used to evaluate the competency of graduate medical students. The pediatric surgery Milestones evolved from version 1.0 to version 2.0, which is simpler and incorporates harmonized milestones and subcompetencies across medical and surgical specialties. Its development aims to improve patient care and maintain public trust in the self-regulation of graduate medical education.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Surgery
Lauren E. McClain, Imran N. Mir, Vishal S. Kapadia, Joseph T. Murphy, Diana L. Diesen
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)