Article
Medicine, General & Internal
Pawel Lawicki, Pawel Malinowski, Joanna Motyka, Michal Lawicki, Aleksandra Kicman, Monika Kulesza, Ewa Gacuta, Tomasz Guszczyn, Marcin Januszkiewicz, Monika Zbucka-Kretowska, Slawomir Lawicki
Summary: The aim of this study was to assess the plasma concentrations and diagnostic utility of MMP-3 and MMP-7 in early-stage breast cancer patients. The results showed that plasma levels of MMP-7 were significantly higher in Luminal A and Luminal B HER2-negative subtype breast cancer patients compared to the healthy group. MMP-7 demonstrated comparable or higher values of diagnostic sensitivity, specificity, positive and negative predictive values, and AUC compared to CA 15-3 or MMP-3. Therefore, combining MMP-7 with CA 15-3 may improve the diagnostic accuracy of breast cancer, particularly in Luminal B HER2-negative subtype patients, and MMP-7 could be a potential new tumor marker.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Albraa Mohamed AbdelDayem, George Abdelfady Nashed, Hany Armia Balamoun, Mohamed Saber Mostafa
Summary: A study showed that negative pressure wound therapy can effectively reduce the incidence of surgical site infection, seroma, and delayed wound healing in closed abdominal incisions, while also reducing hospital stay.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Orthopedics
E. B. Gausden, M. B. Shirley, M. P. Abdel, R. J. Sierra
Summary: Patients who experienced traumatic wound dehiscence following TKA had a 6.5-fold increase in the risk of developing periprosthetic joint infection (PJI). Urgent irrigation and debridement with component retention (IDCR) and postoperative antibiotic therapy are recommended to decrease the risk of PJI.
BONE & JOINT JOURNAL
(2021)
Article
Environmental Sciences
P. Bhanot, S. M. Celin, A. Kalsi, S. K. Singh, S. K. Sahai, P. Sharma
Summary: The study evaluated treatment methods for wastewater from a HMX production facility, successfully degrading HMX and RDX, and reducing COD and nitrate levels. Among the different treatment systems, the photo-Fenton treatment system showed the highest reduction in COD and nitrate content.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Immunology
Yao Tong, Chengrong Bao, Yi-Qiong Xu, Lei Tao, Yao Zhou, Lei Zhuang, Ying Meng, Hui Zhang, Jingjing Xue, Weijun Wang, Lele Zhang, Qingbo Pan, Zhenzhen Shao, Tianran Hu, Qian Guo, Qingsheng Xue, Han Lu, Yan Luo
Summary: The study revealed the crucial role of integrins and matrix metalloproteinases in the pathophysiology of ALI, regulating excessive inflammation and endothelial permeability.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Chenchen Yang, Can Shi
Summary: This meta-analysis aimed to study the correlation between four polymorphisms in the matrix metalloproteinase (MMP) gene and risk of cervical cancer. The results showed that MMP-7 rs11568818 G/A and MMP-3 rs3025058 5A/6A were significantly associated with cervical cancer susceptibility.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Engineering, Biomedical
Sebastian Huth, Laura Huth, Yvonne Marquardt, Maria Cheremkhina, Ruth Heise, Jens Malte Baron
Summary: The study investigated the role of MMP-3 and its regulation by calcium pantothenate in wound healing after ablative fractional laser treatment. Results showed that aftercare treatment with calcium pantothenate accelerated wound closure in MMP-3 expressing models faster than in MMP-3 knockdown models. This study provides evidence for the first time that calcium pantothenate promotes wound healing at least partly via MMP-3.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Critical Care Medicine
Qinghe Meng, Xiaojing Wang, Dandan Guo, Changying Shi, Raymond Gu, Julia Ma, Gary Nieman, Michaela Kollisch-Singule, Juntao Luo, Robert N. Cooney
Summary: This study found that intratracheal nano-formulation of CMT-3 can attenuate LPS-induced acute lung injury and inflammation through multiple mechanisms, demonstrating significant anti-inflammatory effects.
Article
Oncology
Honglei Guo, Yangyang Ji, Bo Zhang, Xin Huang
Summary: Oral squamous cell carcinoma (OSCC) is a common malignancy in the oral cavity with unclear molecular mechanism. This study reveals the important role of Tiam1 in OSCC development, as it competes with Fibulin-3 for nuclear β-catenin translocation, leading to the activation of MMP-7 and promotion of epithelial-mesenchymal transition (EMT) in OSCC.
Article
Oncology
Joshua F. Zeidner, Daniel J. Lee, Mark Frattini, Gil D. Fine, Judy Costas, Kathryn Kolibaba, Stephen P. Anthony, David Bearss, B. Douglas Smith
Summary: Alvocidib, when combined with 7+3 induction therapy, shows promising clinical activity in newly diagnosed acute myeloid leukemia patients, indicating the potential for further investigation of Alvocidib combinations in this population.
CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tzu-Hung Hsiao, Ren Ching Wang, Tsai-Jung Lu, Chien-Hung Shih, Yu-Chen Su, Jia-Rong Tsai, Pei-Pei Jhan, Cai-Sian Lia, Han-Ni Chuang, Kuang-Hsi Chang, Chieh-Lin Teng
Summary: In patients with de novo acute myeloid leukemia (AML), higher levels of Myc gene expression were associated with poor response to the 7 + 3 induction regimen. However, c-Myc protein expression, particularly c-Myc-immunopositivity, could serve as a surrogate marker for predicting the response to 7 + 3 induction chemotherapy. Additionally, c-Myc-immunopositivity improved the specificity of cytogenetics in predicting the chemoresponse to 7 + 3 induction.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Kenny Tang, Andre C. Schuh, Karen W. L. Yee
Summary: With the recent approval of multiple new drugs for AML treatment, the landscape of AML treatment is becoming more targeted, with specific subtypes being treated with specific drugs. While the use of 3+7 alone is decreasing as a standalone treatment option, it still remains the backbone for combination therapy in certain patients.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Oncology
Neil Palmisiano, Grace Jeschke, Lindsay Wilde, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Dolores Grosso, Thomas Klumpp, Ubaldo Martinez, John Wagner, Martin P. Carroll, Alexander Perl, Margaret Kasner
Summary: Relapsed or refractory AML remains common and difficult to treat, with no standard of care. The PI3K/AKT/mTOR pathway demonstrates broad activation across a wide variety of subtypes of AML. Sirolimus is a highly mTORC1-selective allosteric kinase inhibitor that has been extensively studied and used as antirejection prophylaxis in solid organ transplantation.
Article
Hematology
Andrew H. Matthews, Alexander E. Perl, Selina M. Luger, Saar I. Gill, Catherine Lai, David L. Porter, Sarah Skuli, Ximena Jordan Bruno, Martin P. Carroll, Craig W. Freyer, Alison Carulli, Daria V. Babushok, Noelle V. Frey, Elizabeth O. Hexner, Mary Ellen Martin, Shannon R. McCurdy, Edward A. Stadtmauer, Alison W. Loren, Vikram R. Paralkar, Ivan P. Maillard, Keith W. Pratz
Summary: Intensive chemotherapy with cytarabine and anthracycline remains the standard therapy for fit AML patients, but the assessment of fitness remains controversial. Venetoclax and hypomethylating agent combination therapy has improved outcomes in unfit patients, but its efficacy in fit patients has not been well studied. This retrospective study compared outcomes between patients receiving 7 & 3 and ven/HMA as initial therapy, and found that intensive chemotherapy had superior overall survival, but a subset of patients had similar outcomes with ven/HMA.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Megan Othus, Guillermo Garcia-Manero, John Godwin, James Weick, Derek Stirewalt, Frederick Appelbaum, Harry Erba, Elihu Estey
Summary: In a study of 1247 AML patients over four decades, the decade of therapy was found to be the most important factor affecting long-term survival, while achieving CR within 100 days was the second most important variable. Additionally, the protocol/decade of therapy was identified as a significant predictor of survival at year 2 or 3.
LEUKEMIA & LYMPHOMA
(2021)
Review
Medicine, General & Internal
A. J. Lamparello, R. A. Namas, G. Constantine, T. O. McKinley, E. Elster, Y. Vodovotz, T. R. Billiar
JOURNAL OF INTERNAL MEDICINE
(2019)
Article
Cell Biology
Anthony D. Foster, Diego Vicente, Nicholas Clark, Crystal Leonhardt, Eric A. Elster, Thomas A. Davis, Matthew J. Bradley
MEDIATORS OF INFLAMMATION
(2019)
Article
Education, Scientific Disciplines
Colin F. Mackenzie, Samuel A. Tisherman, Stacy Shackelford, Nick Sevdalis, Eric Elster, Mark W. Bowyer
JOURNAL OF SURGICAL EDUCATION
(2019)
Article
Surgery
Felipe A. Lisboa, Christopher J. Dente, Seth A. Schobel, Vivek Khatri, Benjamin K. Potter, Allan D. Kirk, Eric A. Elster
Editorial Material
Medicine, General & Internal
Justin Bare, Leopoldo C. Cancio, David J. Smith, Matthew J. Bradley, Eric A. Elster
Article
Surgery
Matthew Bradley, Christopher Dente, Vivek Khatri, Seth Schobel, Felipe Lisboa, Audrey Shi, Hannah Hensman, Allan Kirk, Timothy G. Buchman, Eric Elster
WORLD JOURNAL OF SURGERY
(2020)
Article
Surgery
Sherry M. Wren, Hannah B. Wild, Jennifer Gurney, Mohana Amirtharajah, Zachary W. Brown, Eileen M. Bulger, Frederick M. Burkle, Eric A. Elster, Joseph D. Forrester, Kent Garber, Richard A. Gosselin, Reinou S. Groen, Gary Hsin, Manjul Joshipura, Adam L. Kushner, Ian Norton, Inga Osmers, Heather Pagano, Tarek Razek, Jesus-Manuel Saenz-Terrazas, Lilli Schussler, Barclay T. Stewart, Abd Al-Rahman Traboulsi, Miguel Trelles, John Troke, Christopher A. VanFosson, Paul H. Wise
Article
Critical Care Medicine
Christopher John Dente, Edda Styrmisdottir, Audrey Shi, Seth Schobel, Vivek Khatri, Benjamin K. Potter, Jonathan A. Forsberg, Timothy Buchman, Allan D. Kirk, Eric Elster
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2020)
Review
Education, Scientific Disciplines
Colin F. Mackenzie, Eric A. Elster, Mark W. Bowyer, Nick Sevdalis
JOURNAL OF SURGICAL EDUCATION
(2020)
Correction
Surgery
Matthew Bradley, Christopher Dente, Vivek Khatri, Seth Schobel, Felipe Lisboa, Audrey Shi, Hannah Hensman, Allan Kirk, Timothy G. Buchman, Eric Elster
WORLD JOURNAL OF SURGERY
(2020)
Editorial Material
Surgery
M. Margaret Knudson, Lenworth M. Jacobs, Eric A. Elster
Article
Surgery
Beau Munoz, Seth A. Schobel, Felipe A. Lisboa, Vivek Khatri, Scott F. Grey, Christopher J. Dente, Allan D. Kirk, Timothy Buchman, Eric A. Elster
Editorial Material
Surgery
Eric Elster, Benjamin K. Potter, Kevin Chung
Article
Emergency Medicine
Patrick F. Walker, Joseph D. Bozzay, Luke R. Johnston, Eric A. Elster, Carlos J. Rodriguez, Matthew J. Bradley
BMC EMERGENCY MEDICINE
(2020)
Review
Oncology
Yuan Gao, Qingyao Shang, Wenyu Li, Wenxuan Guo, Alexander Stojadinovic, Ciaran Mannion, Yan-gao Man, Tingtao Chen
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)