Article
Surgery
Franka Messner, Joanna W. Etra, Jaimie T. Shores, Christopher J. Thoburn, Hubert Hackl, Marcos Iglesias Lozano, Samuel A. J. Fidder, Yinan Guo, Ketevan Kambarashvili, Kemal Alagol, Richa Kalsi, Sarah E. Beck, Carisa Cooney, Georg J. Furtmueller, Johanna Krapf, Byoung Chol Oh, Gerald Brandacher
Summary: Noninvasive immune monitoring using tape-stripping in VCA shows differences in cytokine expression between rejecting and nonrejecting grafts in human patients and swine studies, indicating its feasibility and potential clinical application.
TRANSPLANT INTERNATIONAL
(2021)
Review
Immunology
Lei Zhang, Isabel Arenas Hoyos, Cedric Zubler, Robert Rieben, Mihai Constantinescu, Radu Olariu
Summary: Joint allotransplantation (JA) in vascularized composite allotransplantation (VCA) has the potential for functional reconstruction of severely damaged joints. However, immune rejection limits its clinical use. A systematic review identified 14 relevant articles, showing success in small animal models and failure in human patients with knee allotransplantations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hui Peng, Juping Wang, Xuhong Song, Jiangni Huang, Haoming Hua, Fanlu Wang, Ziyun Xu, Jing Ma, Jie Gao, Jing Zhao, Anna Nong, Dongyang Huang, Bin Liang
Summary: PHLDA1 is involved in the regulation of TLR4 signaling pathway and functions as a negative regulator of LPS-induced proinflammatory cytokine production. It attenuates the production of proinflammatory cytokines by inhibiting the phosphorylation levels of key molecules in TLR4/MyD88-mediated MAPK and NF-kappa B signaling pathways, and by impairing the translocation and responsive element activities of NF-kappa B and AP1. PHLDA1 also represses LPS-induced proinflammatory cytokine production by binding to Tollip and restraining TLR4 signaling pathway. These findings suggest that PHLDA1 may serve as a potential therapeutic target for the treatment of endotoxemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Alireza Soltani Khaboushan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Neuroinflammation plays a fundamental role in the development of epilepsy, and proinflammatory cytokines (PICs) are crucial contributors. Understanding the role of PICs in epilepsy could provide promising targets for treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Genetics & Heredity
Siavash Bolourani, Max Brenner, Ping Wang
Summary: Pulmonary fibrosis is a chronic condition characterized by progressive deposition of connective tissue, leading to a decline in lung elasticity and function. Common causes include inhalation of foreign particles, infections, autoimmune diseases, and idiopathic pulmonary fibrosis. Current therapeutics only modestly slow disease progression. This review focuses on the interplay of DAMP molecules, TLR4, and inflammatory cytokines in the pathogenesis of pulmonary fibrosis and explores potential avenues for developing effective therapeutics.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Chien-Kuo Han, Wei-Fang Lee, Chin-Jung Hsu, Yuan-Li Huang, Chih-Yang Lin, Chun-Hao Tsai, Chien-Chung Huang, Yi-Chin Fong, Min-Huan Wu, Ju-Fang Liu, Chih-Hsin Tang
Summary: DPP4 plays a crucial role in rheumatoid arthritis, with its expression levels closely associated with the development of inflammatory diseases. Increasing DPP4 expression can reduce levels of inflammatory cytokines.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kazuya Nishimura, Tatsuhide Tanaka, Shoko Takemura, Kouko Tatsumi, Akio Wanaka
Summary: The study highlights the role of SNX25 in regulating proinflammatory cytokine expression in macrophages through inhibition of the NF-kappa B signal.
Article
Immunology
Xiaogao Jin, Yanlin Wang
Summary: The study revealed that globular adiponectin induced the production of inflammatory cytokines in Raw 264.7 cells, while full-length adiponectin promoted macrophage migration.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sadaf Jamal Gilani, May Nasser Bin-Jumah, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Muhammad Afzal, Sami Alzarea, Nadeem Sayyed, Imran Kazmi
Summary: The study aimed to confirm the anti-diabetic activity and mechanism of rosinidin in a laboratory setting. Treatment with rosinidin showed positive effects on diabetes, including lower blood glucose levels, increased serum insulin levels, and improved pancreatic function in rats induced with streptozotocin.
Article
Immunology
Jenna L. Riis, Hedyeh Ahmadi, Katrina R. Hamilton, Tracey Hand, Douglas A. Granger
Summary: The study found that IL-1 beta, IL-6, and IL-8 in saliva were more robust to changes in sample collection and cold chain management procedures than TNF-alpha, and all cytokines were positively associated with other oral health-related measures. Based on these findings, analyte-specific guidance for measuring and interpreting salivary cytokine concentrations is recommended.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Qiaoling Wei, Xiaonan Zhuang, Jiawen Fan, Rui Jiang, Qing Chang, Gezhi Xu, Zhiqiang Yu
Summary: The concentrations of proinflammatory cytokines and angiogenesis-related growth factors were found to be elevated in the vitreous humor of highly myopic patients, indicating an increased inflammatory status and higher levels of angiogenic factors in these eyes.
Article
Dermatology
Yun-Zhu Yao, Zhi-Kai Liao, Shan Jiang, Bing-Qi Dong, Long-Fei Luo, Fang Miao, Tie -Chi Lei
Summary: This study investigated the effects of psoriasis-related proinflammatory cytokines on the proliferation and melanogenesis of melanocytes. The increased expression of IL8 and BD3 was associated with an increased number of melanocytes and reduced melanin content. IL8-CXCR2 activation promoted melanocyte proliferation, while BD3 upregulation inhibited melanin synthesis, suggesting that active psoriasis tends to prefer hypopigmentation despite chronic inflammation.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Rheumatology
Takahisa Gono, Yuka Okazaki, Masataka Kuwana
Summary: An antiviral proinflammatory network orchestrated primarily by activated monocytes/macrophages might be responsible for cytokine storm in patients with anti-MDA5-associated interstitial lung disease.
Article
Biotechnology & Applied Microbiology
Junfeng Gao, Yapeng Li, Xiaoyu Guan, Zahraa Mohammed, Gregorio Gomez, Yvonne Hui, Dianzheng Zhao, Carole A. Oskeritzian, Hua Huang
Summary: Our study shows that IL-33 priming significantly enhances the transcription of proinflammatory cytokine and chemokine genes in MCs in response to antigenic stimulation, shedding light on the exacerbation of skin MC-mediated allergic inflammation by epithelial cell-derived cytokine IL-33.
Article
Medicine, General & Internal
Elzbieta Malujlo-Balcerska, Tadeusz Pietras
Summary: This study evaluated the expression levels of certain molecules in patients with depressive disorders and controls. The results showed decreased expression of DIO2 and increased expression of IL1B, IL6, and TNFA in patients. Protein concentrations also showed corresponding changes. The AUC of IL-1 beta, IL-6, DIO1, and DIO3 proteins was >0.7, suggesting their potential as biomarkers for distinguishing patients with depressive disorders. Further studies are recommended to understand the exact role of these molecules.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Chia-An Yang, Jiun-Lu Lin, Shuen-Han Dai, Shih-Ping Cheng
Summary: Water-clear cell parathyroid adenoma is an uncommon cause of primary hyperparathyroidism with certain unique features, including a higher prevalence of complications such as nephrolithiasis and skeletal presentations, and a relatively higher rate of localization on ultrasound examination.
Article
Oncology
Chi-Yu Kuo, Yuan-Ching Chang, Ming-Nan Chien, Jie-Yang Jhuang, Yi-Chiung Hsu, Shih-Yuan Huang, Shih-Ping Cheng
Summary: Aberrant lipid metabolism plays a crucial role in providing energy, building materials, and oxidative stress resistance to cancer cells. This study found that high expression of SREBP1 in invasive thyroid cancer is associated with extrathyroidal extension, advanced disease stage, and shorter disease-specific survival. SREBP1 overexpression promotes cancer cell invasiveness through the upregulation of CYR61/CTGF via the Hippo-YAP pathway.
ENDOCRINE-RELATED CANCER
(2022)
Article
Oncology
Tung-Sun Huang, Jie-Jen Lee, Shih-Yuan Huang, Shih-Ping Cheng
Summary: The study found that the expression of SREBP1 in thyroid cancer cells is affected by various specific inhibitors, among which, Lenvatinib and a MEK inhibitor can suppress SREBP1 expression in BRAF mutant cells, while a galectin-3 inhibitor can reduce SREBP1 expression in both cells in a time- and dose-dependent manner.
ANTICANCER RESEARCH
(2022)
Article
Nutrition & Dietetics
Chien-Liang Liu, Ming-Nan Chien, Yi-Chiung Hsu, Shih-Ping Cheng
Summary: This study analyzed RNA sequencing data of normal thyroid tissues and identified gene expression changes associated with aging. The findings shed light on molecular mechanisms underlying thyroid disorders in the geriatric population.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Chi-Yu Kuo, Jie-Yang Jhuang, Wen-Chien Huang, Shih-Ping Cheng
Summary: This study found that TMSB4X expression was aberrantly increased in various types of thyroid cancer, and higher expression was correlated with advanced disease characteristics.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ming-Chieh Tsai, Cheng-Tzu Hsieh, Hsin-Yin Hsu, Tzu-Lin Yeh, Wen-Chung Lee, Chun-Ju Chiang, Bo-Yu Hsiao, Jing-Rong Jhuang, Wen-Hsuan Tsai, Shih-Ping Cheng, Chao-Liang Chou, Chun-Chuan Lee, Sung-Chen Liu, Po-Jung Tseng, Kuo-Liong Chien
Summary: This study aimed to compare the incidence of coronary heart disease, ischemic stroke, and atrial fibrillation among adults with thyroid cancer compared to the general population. The study found that thyroid cancer patients had a significantly higher risk of coronary heart disease, but no significant association with ischemic stroke, cardiovascular disease, or atrial fibrillation. The risk of coronary heart disease was higher in younger patients with thyroid cancer, and the risk persisted for 5 years after cancer diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Chung-Hsin Tsai, Chi-Yu Kuo, Yi-Shing Leu, Jie-Jen Lee, Shih-Ping Cheng
Summary: While an increasing number of patients undergo lobectomy for low-risk differentiated thyroid cancer, completion thyroidectomy may be needed for some patients to receive radioactive iodine therapy. This study found that completion thyroidectomy requires a longer hospital stay compared to the initial operation. However, there were no differences in operating time, intraoperative blood loss, perioperative drop in calcium levels, and postoperative hospital stay between surgeries. Patients reported higher pain scores on the day of operation and the first postoperative day. Occult papillary microcarcinomas were identified in the contralateral thyroid lobe in 21% of patients.
UPDATES IN SURGERY
(2023)
Article
Medicine, Research & Experimental
Chien-Liang Liu, Shih-Ping Cheng, Wen-Chien Huang, Ming-Jen Chen, Chi-Hsin Lin, Shan-Na Chen, Yuan-Ching Chang
Summary: A study found that SLC35A2 is associated with poor prognosis in breast cancer patients. SLC35A2 transports a specific compound from the cytosol to the endoplasmic reticulum and Golgi. The study also showed that the migratory and invasive capacity of breast cancer cells is influenced by the expression of SLC35A2.
Article
Otorhinolaryngology
Yi-Chiung Hsu, Sheena Yi-Hsin Cheng, Ming-Nan Chien, Shih-Ping Cheng
Summary: The purpose of this study was to explain the burden of thyroid cancer globally by incorporating social and economic factors. The study found that the incidence of thyroid cancer was closely related to the Human Development Index (HDI) of countries, while the disparities in mortality rates were mainly influenced by HDI, current health expenditure, and fine particulate matter (PM2.5) concentrations.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wen-Hsuan Tsai, Yi-Hong Zeng, Chun-Chuan Lee, Ming-Nan Chien, Sung-Chen Liu, Kuo-Liong Chien, Shih-Ping Cheng, Po-Jung Tseng, Ming-Chieh Tsai
Summary: The study aimed to investigate the association between thyroid cancer and coronary artery disease, atrial fibrillation, cerebrovascular disease, and cardiovascular disease mortality. The results showed that the risk of coronary artery disease and atrial fibrillation was significantly increased in patients with thyroid cancer. However, the hazard risk for cardiovascular disease mortality did not differ between patients with and without radioactive iodine treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yi-Chiung Hsu, Wen-Chien Huang, Chi-Yu Kuo, Ying-Syuan Li, Shih-Ping Cheng
Summary: Cellular retinoic acid binding protein 1 (CRABP1) is downregulated in thyroid cancer, and this downregulation promotes epithelial-mesenchymal transition through modulating epidermal growth factor receptor signaling.
MOLECULAR CARCINOGENESIS
(2023)
Article
Endocrinology & Metabolism
Jie-Jen Lee, Yi-Chiung Hsu, Wen-Chien Huang, Shih-Ping Cheng
Summary: This study identified DCSTAMP as a prognostic gene involved in dendritic cell differentiation for thyroid cancer. DCSTAMP was found to be overexpressed in various types of thyroid cancers and associated with poor clinical outcomes. Further studies are needed to explore the potential immunomodulatory role of DCSTAMP in thyroid cancer.
Article
Endocrinology & Metabolism
Chien-Liang Liu, Yi-Chiung Hsu, Chi-Yu Kuo, Jie-Yang Jhuang, Ying-Syuan Li, Shih-Ping Cheng
Summary: CRABP2 expression is upregulated in thyroid cancer and associated with adverse prognosis. CRABP2 expression is related to the invasion capacity of thyroid cancer cells and may promote invasion through the integrin/focal adhesion kinase/AKT pathway.
Article
Surgery
Hui-Ju Tsou, Shou-Sen Huang, Chung-Hsin Tsai, Shih-Ping Cheng, Tun-Pang Chu
Summary: This study investigated whether there were differences in the perioperative outcomes of laparoscopic appendectomy during the COVID-19 pandemic and found no significant differences between different years.
FORMOSAN JOURNAL OF SURGERY
(2022)
Review
Endocrinology & Metabolism
Chia-An Yang, Jiun-Lu Lin, Shuen-Han Dai, Shih-Ping Cheng
Summary: Water-clear cell parathyroid adenoma is a rare cause of primary hyperparathyroidism. It is characterized by larger tumor size, relatively indolent biochemical profile, high prevalence of complications and nonspecific symptoms, an isoechoic appearance on ultrasonography, and reduced scintigraphic sensitivity.
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)