Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Genetics & Heredity
Jian Zhao, Shi-Zhe Yu, Qiang Cai, Duo Ma, Long Jiang, Ling-Peng Yang, Zhi-Yong Yu
Summary: Key genes involved in cell cycle, DNA replication, and p53 signaling pathway were identified in the early stage of liver regeneration in mice after partial hepatectomy (PH). Ube2c was found to play a crucial role in regulating hepatocyte proliferation by modulating genes such as Ccna2, Cdkn1a, Chek1, and Mcm5.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Sinan Efe Yazici, Mustafa Emre Gedik, Can Berk Leblebici, Kemal Kosemehmetoglu, Gurcan Gunaydin, Ahmet Bulent Dogrul
Summary: In this study, the researchers investigated the mechanisms of liver regeneration and found that Vegf, endocan, endostatin, and eEF2K play important roles in the process of liver regeneration after partial hepatectomy. Specifically, endocan may serve as a useful biomarker for clinical prognosis.
MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Hong Liu, Anqi Zhou, Zhiwen Fan, Xi Zhu, Xiulian Miao
Summary: This study investigated the role of ubiquitin-specific peptidase 47 (USP47) in liver regeneration. The results showed that USP47 expression was up-regulated in hepatocytes isolated from mice subjected to partial hepatectomy or exposed to HGF treatment. E2F1 was identified as the primary regulator of USP47 transcription. USP47 was found to play an essential role in liver regeneration, as its inhibition impaired liver regeneration in mice and its over-expression enhanced hepatocyte proliferation in vitro and promoted liver regeneration in mice. A positive correlation between USP47 expression and hepatocyte proliferation was also observed in patients with acute liver failure.
Review
Biotechnology & Applied Microbiology
Yi Wu, Ning Li, Xinyu Shu, Wang Li, Xiaoyu Zhang, Dongyuan Lu, Mian Long
Summary: The liver is a complex organ with vital functions and regenerative capacity after tissue injury. Mechanical cues play a significant role in liver regeneration, including changes in hemodynamics and mechanical forces within the liver. Understanding the mechanotransductive pathways and mechanocrine responses can contribute to a comprehensive understanding of liver regeneration. Proper adjustment of mechanical loading may serve as an effective therapy for liver injury and diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Dakota R. Robarts, Steven R. McGreal, David S. Umbaugh, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy, Norman Lee, Hartmut Jaeschke, Sumedha Gunewardena, Stephen A. Whelan, John A. Hanover, Natasha E. Zachara, Chad Slawson, Udayan Apte
Summary: This study reveals the critical role of O-GlcNAcylation in the termination of liver regeneration through regulation of HNF4 alpha in hepatocytes.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Yuan-E Lian, Yan-Nan Bai, Jian-Lin Lai, Ai-Min Huang
Summary: The study found that aberrant autophagy in fibrotic liver leads to impaired liver regeneration. Enhancement of autophagy improves hepatocyte proliferative capacity and restricts cellular hypertrophy and binuclearity ratio.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
M. Herranz-Iturbide, J. Lopez-Luque, E. Gonzalez-Sanchez, D. Caballero-Diaz, E. Crosas-Molist, B. Martin-Mur, M. Gut, A. Esteve-Codina, V Jaquet, J. X. Jiang, N. J. Torok, I Fabregat
Summary: NOX4 plays a role in promoting hepatocyte proliferation and repair during liver regeneration, with its deletion leading to accelerated liver recovery. NOX4-deleted mice show faster cell proliferation and better liver weight restoration, suggesting the potential of NOX4 as a therapeutic target for improving liver regeneration.
Article
Biochemistry & Molecular Biology
Mingfei Han, Xian Liu, Wen Zhang, Mengnan Wang, Wenjing Bu, Cheng Chang, Miao Yu, Yingxing Li, Chunyan Tian, Xiaoming Yang, Yunping Zhu, Fuchu He
Summary: TSMiner is an analytical tool that can capture dynamic regulatory events from time-series gene expression profiles, demonstrating superior sensitivity and accuracy compared to existing methods. When applied to a mouse liver regeneration dataset, TSMiner identified numerous transcriptional activators and repressors, revealing temporal dynamics of key biological processes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Article
Biotechnology & Applied Microbiology
Saisai Wei, Qiang Zheng, Yu Pan, Yunwan Xu, Jiacheng Tang, Xiujun Cai
Summary: The study revealed that liver regeneration leads to reprogramming of gene expression profiles, while core clock genes' rhythm remains stable. Performing partial hepatectomy in the evening may result in retarded liver regeneration due to the accumulation of DEC1.
Article
Biochemistry & Molecular Biology
Bo Zhang, Dongyue Lv, Yang Chen, Weijue Nie, Yang Jiao, Junqi Zhang, Xiaoxiao Zhou, Xiao Wu, Siqing Chen, Tonghui Ma
Summary: This study reports the crucial role of AQP9 in liver regeneration. AQP9 deficiency leads to delayed liver regeneration, increased mortality, aggravated liver injury, and abnormal glucose metabolism. AQP9 deficiency also results in H2O2 accumulation and oxidative injury.
Article
Gastroenterology & Hepatology
Joaquim Javary, Nathalie Allain, Zakaria Ezzoukhry, Sylvaine Di Tommaso, Jean-William Dupuy, Pierre Costet, Nathalie Dugot-Senant, Frederic Saltel, Violaine Moreau, Pierre Dubus, Samira Benhamouche-Trouillet
Summary: Previous studies have shown that Reptin is crucial for hepatocyte proliferation in vivo and liver regeneration, as observed in the Reptin(LKO) mouse model. The impaired liver regeneration in Reptin(LKO) mice post partial hepatectomy is associated with decreased cyclin-A expression and mTORC1 and MAPK signaling. The progressive loss of Reptin invalidation in the model leads to atypical liver regeneration, with hypertrophic and proliferative hepatocytes replacing hypotrophic ones.
LIVER INTERNATIONAL
(2021)
Article
Engineering, Environmental
Fan Li, Guili Song, Xiaochen Wang, Yumiao Sun, Shanqi Zhou, Yindan Zhang, Jianghuan Hua, Biran Zhu, Lihua Yang, Wei Zhang, Bingsheng Zhou
Summary: This study reveals the adverse effects of DBDPE on liver development and regeneration in zebrafish. The underlying mechanisms involving disturbed signaling pathways and cell cycle arrest were identified. These findings have implications for ecological and health risk assessment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Gene G. Lamanilao, Murat Dogan, Prisha S. Patel, Shafquat Azim, Disha S. Patel, Syamal K. Bhattacharya, James D. Eason, Canan Kuscu, Cem Kuscu, Amandeep Bajwa
Summary: Surgical modalities can be used to treat advanced liver disease due to the liver's ability to regenerate. Mitochondria play crucial roles in liver regeneration by coordinating energy production, driving cellular processes, and mediating apoptosis to terminate the regenerative process. Attenuation of mitochondrial activity delays liver regeneration, and mitochondrial dysfunction is associated with liver failure following resection. Mitochondria therapy strategies involve transplanting healthy donor mitochondria to promote regeneration.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)