Journal
PLANTA MEDICA
Volume 81, Issue 3, Pages 241-246Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1396151
Keywords
Perovskia atriplicifolia; Lamiaceae; icetexane diterpenoids; anti-HBV activity
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Funding
- National Natural Science Foundation of China (NSFC) [21162041]
- Education Department of Yunnan Province (IRTSYN)
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Five new icetexane diterpenoids, namely, perovskatones B-D (1, 3, 4), 1-hydroxybrussonol (2), and 1-hydroxypisiferanol (5), were isolated from Perovskia atriplicifolia, together with a new natural product (6) and two known compounds, przewalskin E (7) and brussonol (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D, and 2DNMR data. Compounds 1-8 were assayed for their inhibitory hepatitis B virus activities in the HepG 2.2.15 cell line. The results suggested that compounds 1 and 2 possessed noticeable anti-hepatitis B virus activity in vitro, suppressing the replication of hepatitis B virus DNA with selectivity index values of 154.3 and 137.7, respectively.
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