Article
Chemistry, Medicinal
Se-In Choi, Hee-Soo Han, Jae-Min Kim, Geonha Park, Young-Pyo Jang, Yu-Kyong Shin, Hye-Shin Ahn, Sun-Hee Lee, Kyung-Tae Lee
Summary: The study showed that EEB exhibits a photoprotective effect against UVB-induced skin aging by regulating MMP-1 and pro-collagen type I production through MAPK/AP-1 and Smad pathways. This suggests that EEB could be a potential natural remedy for preventing UVB-induced skin damage.
Article
Chemistry, Medicinal
Sofia Pinto, Maria Manuela Gaspar, Lia Ascensao, Pedro Faisca, Catarina Pinto Reis, Rita Pacheco
Summary: This study aimed to design a novel oral formulation of bovine albumin serum nanoparticles loaded with Eisenia bicyclis extract and evaluate its health benefits in preventing hypercholesterolemia and cardiovascular diseases (CVDs). The results showed that the nanoformulation was more effective than the free extract in inhibiting cholesterol biosynthesis and reducing cholesterol permeation. Both in vitro and in vivo assays demonstrated the safety and metabolic effects of the extract and nanoparticle formulation. These preliminary results suggest that seaweed extract and the nanoformulation may provide a safe and simple alternative to reduce cholesterol levels and prevent hypercholesterolemia, a major risk factor for CVDs.
Article
Agriculture, Dairy & Animal Science
Xiaoyu Men, Su Li, Xiaojing Cai, Lian Fu, Yi Shao, Yan Zhu
Summary: Pseudorabies virus (PRV) is a major threat to swine industry and can potentially cause viral encephalitis in humans. Due to emerging variants, finding effective antiviral agents against PRV is crucial. This study evaluated the antiviral activity of luteolin against PRV both in vitro and in vivo. Luteolin demonstrated significant inhibition of PRV replication, reduced viral RNA and protein expression, decreased apoptosis, improved survival rate in mice, and reduced viral loads and brain lesions. These findings suggest that luteolin holds promise as a new alternative antiviral drug for PRV infection.
Article
Pharmacology & Pharmacy
Zhong Li, Jimin Xu, Yuekun Lang, Xiangmeng Wu, Saiyang Hu, Subodh Kumar Samrat, Anil M. Tharappel, Lili Kuo, David Butler, Yongcheng Song, Qing-Yu Zhang, Jia Zhou, Hongmin Li
Summary: Erythrosin B is an effective antiviral against Zika virus both in vitro and in vivo, and its derivatives are non-toxic to human cells.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Medicinal
David Lopez-Tejedor, Rafael Claveria-Gimeno, Adrian Velazquez-Campoy, Olga Abian, Jose M. Palomo
Summary: Tyrosinases extracted and purified from commercial Agaricus bisporus protein extract and white mushrooms demonstrated high antiviral activity against hepatitis C virus. The newly discovered 50 kDa isoform showed even greater antiviral capacity than the well-known 45 kDa isoform. This antiviral activity was directly related to the enzymatic activity of tyrosinases.
Article
Virology
Peiwen Zhou, Zizhao Lao, Haishan Long, Pan Pan, Feng Liao, Wenjiang Zheng, Zonghui Li, Jianfeng Dai, Helu Liu, Yong Jiang, Xiaohong Liu, Wenbiao Wang, Jianguo Wu, Geng Li
Summary: This study found that aloperine, a quinolizidine alkaloid, has antiviral potential against Zika virus (ZIKV) infection. It effectively inhibits ZIKV infection in vitro and in vivo, targeting the domain RNA-dependent RNA polymerase (RDRP) of ZIKV NS5 protein. Aloperine reduced the viral load in mice and improved survival rates. These findings suggest that aloperine could be a promising antiviral drug against ZIKV.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Dong-Hwi Kim, Hee-Seop Ahn, Hyeon-Jeong Go, Da-Yoon Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, In-Soo Choi
Summary: The research demonstrated that heme oxygenase-1 (HO-1) has antiviral activity against Hepatitis A virus (HAV) infection in cells, effectively suppressing viral replication in vitro. HO-1 inducers and inhibitors showed different effects on HAV-infected cells, providing new insights into the development of antiviral drugs targeting HAV.
Article
Biochemistry & Molecular Biology
Teng Zhang, Yunchao Liu, Yumei Chen, Jucai Wang, Hua Feng, Qiang Wei, Shuangshuang Zhao, Suzhen Yang, Hongfang Ma, Dongmin Liu, Gaiping Zhang
Summary: The study identified a novel type I interferon IFN-88 that exhibited significant antiviral effects against pseudorabies virus infection and increased the expression of IFN-stimulated genes to resist viral invasion. This highlights the potential of IFN-88 as an antiviral agent for preventing PRV infection and expanding the function of IFN antiviral drugs in the future.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yoshimasa Sugiura, Masakatsu Usui, Hirotaka Katsuzaki, Kunio Imai, Ryusuke Tanaka, Teruo Matsushita, Masaaki Miyata
Summary: The study isolated dieckol from the brown alga E. nipponica, demonstrating its anti-allergic effects by suppressing the release of various bioactive molecules. With the increasing prevalence of allergies globally, dieckol could serve as a potential health food ingredient to prevent lifestyle-related diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Poliana Gomes da Silva, Aventino H. Fonseca, Malu P. Ribeiro, Taizia D. Silva, Cristiane F. F. Grael, Lindomar J. Pena, Tania M. S. Silva, Eduardo de Jesus Oliveira
Summary: The study conducted bioassay-guided fractionation of bisbenzylisoquinoline alkaloids from Cissampelos sympodialis, identifying warifteine as a potent antiviral compound against Zika virus. Warifteine significantly reduced virus titer in infected cells with selective activity. This suggests the potential of bisbenzylisoquinoline alkaloids as new antiviral agents or pharmacophores for researching ZIKV antiviral activity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Rafayela Grigoryan, Erik Arabyan, Roza Izmailyan, Zaven Karalyan, Nuno Jordao, Fernando Ferreira, Hovakim Zakaryan
Summary: BQR effectively inhibits ASFV replication by depleting pyrimidine pool and inducing cellular antiviral response, showing a promising strategy for developing antiviral agents against ASFV.
Article
Multidisciplinary Sciences
P. Patil, K. Alagarasu, D. Chowdhury, M. Kakade, S. Cherian, S. Kaushik, J. P. Yadav, D. Parashar
Summary: This study demonstrates the antiviral activity of commercially available Carica papaya leaves extract (CPLE) based products and CPLE prepared in different formulations against dengue virus type 2 (DENV-2) and chikungunya virus (CHIKV) in an in-vitro system. Effective formulations were found under different treatment conditions. The results suggest the potential of CPLE formulations as treatments for dengue and chikungunya, but further validation in in-vivo models is needed.
Article
Veterinary Sciences
Xiaojing Cai, Yi Shao, Zhiying Wang, Yongkang Xu, Zhiyuan Ren, Lian Fu, Yan Zhu
Summary: Pseudorabies virus (PRV) is a significant pathogen of swine with potential implications for human health. Dandelion aqueous extract (DAE) was found to have a potent inhibitory capability against PRV infection both in vitro and in vivo. DAE inhibited the multiplication of PRV, the expression of viral genes, and reduced viral load and brain damage in PRV-infected mice. DAE also regulated cytokine levels in PRV-infected mouse serum. These findings suggest that DAE could be a potential traditional Chinese medicine herb for treating PRV infection.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Jeng-Wei Lu, Yen-Chen Chen, Chin-Kai Huang, Kuan-Chih Lin, Yi-Jung Ho
Summary: Anidulafungin exhibits antiviral activity against ZIKV by significantly reducing viral RNA levels and infectivity. Combination therapy with T-1105 shows a synergistic effect in treating ZIKV infection.
ANTIVIRAL RESEARCH
(2021)
Article
Virology
Zheng Chen, Jinfeng Chen, Xiaodong Wei, Huiying Hua, Ruiming Hu, Nengshui Ding, Jinhua Zhang, Deping Song, Yu Ye, Yuxin Tang, Zhen Ding, Shaoyong Ke
Summary: This study found that some carbazole derivatives have inhibitory effects on PEDV replication and exhibit inhibition at the early stage. This provides evidence for these compounds to be potential inhibitors of PEDV, and offers candidates for the development of novel therapeutic agents.
