Article
Chemistry, Analytical
Fahime Shahsavari, Mohsen Bakhshi Kashi, Saeed Farzanefar, Elisabeth Eppard, Nasim Vahidfar
Summary: Breast cancer is a deadly malignancy, and early and accurate diagnosis is crucial for long-term survival. Nuclear medicine has recently introduced a novel method for evaluating breast cancer at both early and advanced stages. This method is based on sentinel lymph node scintigraphy, which is preferable to axillary lymphadenectomy due to its lower postoperative complications. Radiocolloids have shown superior effectiveness in detecting metastatic lymph nodes. In this short review, we will introduce the important role of radiopharmaceuticals in the clinical application of breast cancer lymphoscintigraphy.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Francesco Giammarile, Sergi Vidal-Sicart, Diana Paez, Olivier Pellet, Estrada-Lobato Enrique, Miriam Mikhail-Lette, Olga Morozova, Navarro Marulanda Maria Camila, Rodriguez Sanchez Diana Ivonne, Roberto C. Delgado Bolton, Renato A. Valdes Olmos, Giuliano Mariani
Summary: Breast cancer is the most common cancer in women worldwide, and sentinel lymph node biopsy is a highly reliable method for detecting lymph node metastasis. Despite some variations and differences, improved accuracy can be achieved with the accumulation of experience.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Francesca Magnoni, Giovanni Corso, Laura Gilardi, Eleonora Pagan, Giulia Massari, Antonia Girardi, Federico Ghidinelli, Vincenzo Bagnardi, Viviana Galimberti, Chiara Maria Grana, Paolo Veronesi
Summary: This study investigated the clinical significance of nonvisualized sentinel lymph nodes in axillary surgery for breast cancer, analyzing their incidence, identification rate during surgery, factors associated with them, and related axillary management. Patients with non-vSLNs had an increased risk for SLN metastasis, highlighting the importance of consistent detection during surgery in reducing unnecessary axillary dissection.
Article
Medicine, Research & Experimental
Nir Hirshoren, Narmeen abd el Qadir, Jeffrey M. Weinberger, Ron Eliashar, Simona Ben-Haim
Summary: This retrospective cohort study investigates the importance of different phases of lymphoscintigraphy, particularly focusing on the late static phase and the discovery of distal echelon solitary positive sentinel nodes that may have been overlooked by other methods.
Review
Health Care Sciences & Services
Vincenzo Cuccurullo, Marco Rapa, Barbara Catalfamo, Giuseppe Lucio Cascini
Summary: With the advancements in sentinel lymph node technology, histopathological staging can be done using lymphatic mapping and selective lymphadenectomy. Structural imaging techniques like US, CT, and MR allow precise measurement of lymph node volume, which is strongly linked to cancerous involvement. While hybrid imaging has shown higher accuracy than standard imaging in visualizing the sentinel lymph node, it hasn't impacted surgical detection. Non-radiological fields such as ophthalmology and dermatology are introducing alternatives like fluorescence or opto-acoustic imaging. This paper analyzes the advantages and limitations of innovative methods in sentinel lymph node detection, including the continued importance of lymphoscintigraphy techniques.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Piotr Kedzierawski, Artur Bocian, Agnieszka Radowicz-Chil, Anna Huruk-Kuchinka, Ryszard Mezyk
Summary: The purpose of this study was to determine the correlation between the biological subtype of breast cancer and the risk of metastasis to a sentinel lymph node. In the analyzed group of 1018 women with breast cancer, 57% were classified as Luminal A subtype. A positive sentinel lymph node was found in 26.5% of the women.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Oncology
Swadha D. Guru, Tanya L. Hoskin, Dana H. Whaley, Mark A. Nathan, James W. Jakub
Summary: There are limited data on the optimal injection technique for repeat sentinel lymph node (rSLN) surgery. Preoperative lymphoscintigraphy is beneficial in patients with recurrent breast cancer. Periareolar and peritumoral injections had similar incidence of sentinel lymph node identification and aberrant drainage.
CLINICAL BREAST CANCER
(2021)
Review
Medicine, General & Internal
Alexandra Maria Lazar, Mario-Demian Mutuleanu, Paula Monica Spiridon, Cristian Ioan Bordea, Tatiana Lucia Suta, Alexandru Blidaru, Mirela Gherghe
Summary: This study investigates the role of SLNB in breast cancer patients who underwent prior NAC and compares the results with other studies. The findings show that SLNB accurately determines lymph node status with low recurrence rates.
Article
Multidisciplinary Sciences
Miaomiao Zhao, Yan Zheng, Jian Chu, Zhenhua Liu, Fenglin Dong
Summary: This study developed a novel non-invasive method to predict sentinel lymph node metastasis in breast cancer by analyzing ultrasound imaging characteristics and peripheral blood T-cell subsets. The constructed combined model showed good performance and can be used to guide clinical decisions in breast surgery.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Anastasia Bothou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Georgia Margioula-Siarkou, Stefanos Zervoudis, Alexandros Sotiriadis, Frederic Amant, Konstantinos Dinas
Summary: Sentinel lymph node biopsy (SLNB) appears to be a safe and effective technique for breast cancer during pregnancy, according to this systematic review. A total of 63 articles were included, with 47 strongly in favor of SLNB in pregnancy-related breast cancer (PABC), 4 partially in favor, 10 strongly against, and 2 partially against. Sub-categorization based on study type showed that the majority of studies in favor had higher levels of evidence. In total, 382 women with PABC underwent SLNB, and full data were reported for 237 cases. The overall live birth rate was 95.8%, while the overall neonatal complication rate was 3.4%. No cases of maternal side effects or anaphylactic reaction, maternal death, stillbirth, or neonatal death were reported (0%).
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Amy K. Schulze, Tanya L. Hoskin, Mary M. Mrdutt, Robert W. Mutter, Tina J. Hieken
Summary: This study explores the feasibility and therapeutic impact of repeat sentinel lymph node surgery in patients with local recurrence post-mastectomy. The results show that this approach is successful and informative, reducing axillary dissection rates and potentially guiding adjuvant radiation target volumes and systemic therapies.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Tibor A. Zwimpfer, Fabienne D. Schwab, Daniel Steffens, Felix Kaul, Noemi Schmidt, James Geiger, Franziska Geissler, Viola Heinzelmann-Schwarz, Walter P. Weber, Christian Kurzeder
Summary: In this case report, a 37-year-old patient with CALNM in a ipsilateral relapse of breast cancer is described. The use of delayed lymphoscintigraphy and the sentinel procedure aided in accurate staging and treatment. The findings suggest that CALNM without evidence of systemic metastasis should be considered a regional event in recurrent breast cancer, allowing for a curative approach.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francisco M. Canete-Sanchez, Xavier L. E. Boulvard-Chollet, Xabier Chamorro, Pablo Javier Marrodan, Puy Garrastachu Zumaran, Rafael Ramirez Lasanta, Patrick M. Colletti, Francesco Giammarile, Roberto C. Delgado Bolton
Summary: This study designed two concave lead shields that significantly reduce the scatter point of injection and the need for repositioning in sentinel lymph node lymphoscintigraphy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)