Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 118, Issue 3, Pages 431-439Publisher
WILEY
DOI: 10.1002/jso.25156
Keywords
biomarker; cirrhosis; hepatocellular carcinoma; liver diseases; microRNA-26
Funding
- Showalter Trust Foundation
- American Cancer Society Institutional Research Grant (ASCIRG grant mechanism)
- IU Simon Cancer Center
- American Cancer Society Research Scholar Grant [RSG-18-105-01-RMC]
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Background and ObjectivesHepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) exhibit lower tumor microRNA-26a (miR-26a) expression which is associated with worse outcomes. It is unknown if similar miR-26a loss occurs inHCC developed in other liver diseases. We examined tumor miR-26a expression and its impact on recurrence and mortality in a North American HCC cohort. MethodsMiR-26a levels from tumor and surrounding nontumor liver tissue in 186 subjects were collected. We defined lower tumor expression of miR-26a as <1-fold that of the adjacent nontumor liver tissue. ResultsViral hepatitis (42%; 40% hepatitis C and 2% HBV), alcohol (19%), and nonalcoholic fatty liver disease (NAFLD) (18%) were the most common causes of liver disease. The prevalence of lower tumor miR-26a expression was 68%, and it was evident in HCCs arising in all etiologies (viral hepatitis 60%, alcohol 61%, and NAFLD 76%). Subjects with lower tumor miR-26a expression had significantly higher tumor recurrence (hazard ratio [HR], 2.45; 95% confidence interval[CI], 1.18 to 5.1; P=0.016) and higher mortality of borderline significance (HR, 1.51; 95% CI, 0.94 to 2.41; P=0.086). ConclusionReduced miR-26a expression is a common phenomenon in HCC arising in North American patients with different underlying liver diseases and may increase recurrence and mortality after surgery.
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