Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 109, Issue 4, Pages 383-388Publisher
WILEY-BLACKWELL
DOI: 10.1002/jso.23474
Keywords
isolated hepatic perfusion; percutaneous hepatic perfusion; melphalan
Funding
- Delcath Systems, Inc
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Unresectable hepatic metastases from melanoma present a challenge to the physician. Although there have been advances in systemic therapies for patients with metastatic cutaneous melanoma to the liver, the overall prognosis is poor and is worse in patients with metastatic ocular melanoma. Isolated hepatic perfusion, open or percutaneous, allows high doses of cytotoxic chemotherapy to be delivered directly to the liver while minimizing systemic exposure, and has emerged as a viable treatment options for these complex patients. J. Surg. Oncol. 2014 109:383-388. (c) 2013 Wiley Periodicals, Inc.
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