Article
Oncology
Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, Satoshi Kataoka, Hirotaka Furuke, Wataru Takaki, Kazuya Takabatake, Jun Kiuchi, Takuma Ohashi, Hiroki Shimizu, Yusuke Yamamoto, Shuhei Komatsu, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Eigo Otsuji
Summary: By removing gastric cancer-derived small extracellular vesicles, the proliferative and migrative abilities of gastric cancer cells can be suppressed, reducing their adhesion to peritoneal mesothelial cells. This alteration in gene expression pathways of gastric cancer cells leads to inhibition of gastric cancer cell growth and peritoneal dissemination in vivo, providing insights into a novel therapy for inhibiting peritoneal dissemination of gastric cancer.
Article
Oncology
Zhenhao Zeng, Wenrui He, Yi Jiang, Hao Jiang, Xiaofeng Cheng, Wen Deng, Xiaochen Zhou, Cheng Zhang, Gongxian Wang
Summary: MAPK8IP2 is highly expressed in prostate cancer and is associated with adverse prognosis. Genetic alterations and DNA methylation of MAPK8IP2 are correlated with poor prognosis. MAPK8IP2 may be involved in the MAPK signaling pathway and has been demonstrated to affect cell proliferation, migration, and invasion of prostate cancer cells in vitro.
Article
Medicine, General & Internal
Jong Mi Kim, Gun Oh Chong, Nora Jee-Young Park, Yeong Eun Choi, Juhun Lee, Yoon Hee Lee, Dae Gy Hong, Ji Young Park
Summary: The study evaluated the presence of residual cancer cells (RCCs) in intraoperative peritoneal washes and their correlation with survival and clinicopathological parameters in patients undergoing radical hysterectomy for cervical cancer. Results showed that RCCs were associated with neoadjuvant chemotherapy and large tumor size, but did not significantly impact survival outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xiong Guo, Yujun Wang, Lang Zha, Hui Li, Kun Qian
Summary: In this study, a prognostic model based on DNA methylation regulator-related lncRNAs was established to predict the survival of gastric cancer patients. The study found that a high lncRNA score was associated with poor prognosis, decreased tumor mutation burden, and immunosuppression, while a low lncRNA score was associated with increased neoantigen load and increased response to immunotherapy targeting PDL1/CTLA4. Additionally, a low lncRNA score was associated with significant therapeutic advantage and clinical benefit.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medical Laboratory Technology
Xuan-Yu Hu, Zhe-Nan Ling, Lian-Lian Hong, Qi-Ming Yu, Pei Li, Zhi-Qiang Ling
Summary: The study found that the methylation status of THBS1 in tumor tissues, PPLF, and serum was closely related to peritoneal dissemination in GC patients, suggesting its potential as a predictive biomarker.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Genetics & Heredity
Donghui Liu, Long Li, Liru Wang, Chao Wang, Xiaowei Hu, Qingxin Jiang, Xuyao Wang, Guiqin Xue, Yu Liu, Dongbo Xue
Summary: The study integrated GC DNA methylation data from public databases to identify reliable diagnostic and prognostic markers, and constructed corresponding models. These models can assist in accurate and individualized treatment of GC.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Fen Liu, Zongcheng Yang, Lixin Zheng, Wei Shao, Xiujie Cui, Yue Wang, Jihui Jia, Yue Fu
Summary: Using WGCNA, the study identified hub genes related to gastric cancer progression, constructed a gastric cancer risk model, and identified high-risk patients, demonstrating that the risk score can be used as an independent prognostic factor for gastric cancer. High-risk patients had poorer prognosis and more immune characteristics suitable for immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nuo Chen, Yan Hu, Ren-Ze Huang, Dong-Liang Chen
Summary: Circular RNA TNIK is upregulated in gastric cancer and correlates with aggressive tumor phenotypes and poor prognosis. It acts as a molecular sponge for miR-138-5p to regulate ZEB2 expression, promoting gastric cancer cell proliferation, invasion, tumorigenesis, and metastasis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin, Weihua Fu
Summary: The study revealed that upregulated expression of CDH6 in gastric cancer is associated with diagnosis and prognosis, making it a potential independent molecular biomarker.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kanghui Liu, Peng Xu, Jialun Lv, Han Ge, Zhengyuan Yan, Shansong Huang, Bowen Li, Hao Xu, Li Yang, Zekuan Xu, Diancai Zhang
Summary: Peritoneal metastasis (PM) is a significant mode of metastasis in gastric cancer (GC), associated with poor prognosis. However, the molecular mechanism of PM remains unclear. This study revealed that NSUN2, an RNA modifier, is upregulated in PM and patients with high NSUN2 expression have a worse prognosis. Mechanistically, NSUN2 regulates ORAI2 mRNA stability through m5C modification, promoting ORAI2 expression and resulting in peritoneal metastasis and colonization in GC.
Article
Medicine, General & Internal
Fanqi Wu, Longguo Zhang, Li Wang, Dekui Zhang
Summary: In this study, AGT was found to be significantly overexpressed in GC tissues and correlated with prognosis and immune infiltration in gastric cancer patients. Methylation analysis indicated that hypomethylation may lead to abnormal upregulation of AGT. These findings highlight the important role of AGT in the development of gastric cancer.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Haijiao Yan, Wenyu Chen, Kele Ge, Xizheng Mao, Xiaodong Li, Wensong Liu, Jun Wu
Summary: Methylation of SFRP2 in ctDNA is correlated with clinical outcomes in GC patients, with higher levels associated with poorer prognosis. Dynamic changes in SFRP2 methylation post-treatment are also predictive of survival in advanced GC patients, providing a potential biomarker for prognosis prediction and monitoring.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Oncology
Jinyun Wang, Dingwei Liu, Yong Xie
Summary: This study found that GHRL is expressed at lower levels in gastric cancer patients and is correlated with sample type, cancer stage, and worse survival. It also discovered a correlation between GHRL expression and immune regulatory factors, infiltrating immune cells in gastric cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Gianluca Tedaldi, Chiara Molinari, Celina Sao Jose, Rita Barbosa-Matos, Ana Andre, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Luca Saragoni, Paolo Morgagni, Francesca Rebuzzi, Matteo Canale, Sara Pignatta, Elisa Ferracci, Giovanni Martinelli, Guglielmina Nadia Ranzani, Carla Oliveira, Daniele Calistri, Paola Ulivi
Summary: This study aimed to elucidate the role of genetic variants and DNA methylation of CDH1 promoter and enhancers in the regulation of gene expression in gastric cancer. The results showed that alterations in terms of genetic variants and DNA methylation patterns of both promoter and enhancers are associated with CDH1 expression levels and have a role in its regulation. The study revealed different methylation patterns in patients and controls, GC cell lines and GC tissues, expressing different E-cadherin levels.
Article
Immunology
Zitao Liu, Huakai Tian, Zhengming Zhu
Summary: This study aimed to explore the clinical significance of circulating tumor cells (CTCs) and cytokines in predicting peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients preoperatively. The levels of CTCs and interleukin-6 (IL-6) were found to be higher in AGC patients with PM compared to those without PM. Multivariate logistic regression analysis identified IL-6 > 12.22 pg/mL, CTCs > 4/5mL, CA724 > 6 IU/mL, CA125 > 35 U/mL, and tumor size > 5 cm as independent risk factors for PM in AGC. The nomogram constructed from these risk factors demonstrated good discriminative ability and clinical utility.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
