Article
Medicine, Research & Experimental
Ju-Yeon Kim, Eun Jung Jung, Jae-Myung Kim, Youngsim Son, Han Shine Lee, Seung-Jin Kwag, Ji-Ho Park, Jin-Kyu Cho, Han-Gil Kim, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong, Young-Tae Ju
Summary: miR-221 and miR-222 play a significant role in the progression and invasion of breast cancer cells by regulating the target gene ANXA3. The expression levels of miR-221/222 are associated with aggressive characteristics of breast cancer, and downregulation of ANXA3 through increased expression of miR-221/222 reduces breast cancer progression and increases the effectiveness of chemotherapy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Oncology
Sayed Shahabuddin Hoseini, Mallika Vadlamudi, Madelyn Espinosa-Cotton, Hoa Tran, Yi Feng, Hong-Fen Guo, Hong Xu, Irene Cheung, Nai-Kong Cheung
Summary: This study presented data on three bispecific antibodies against the CD33 IgV and IgC domains, showing their effect on AML cell lines through in vitro binding and cytotoxicity assays. The findings support further clinical development of these BsAbs for potential first-in-human phase I clinical trial.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Hyeonseo Hwang, Hee Ryung Chang, Daehyun Baek
Summary: MicroRNAs (miRNAs) play important roles in regulating biological pathways and processes. Previous studies have used large-scale datasets to predict the functional targets of miRNAs, but current prediction tools have limited accuracy and high false positive rates. Utilizing additional determinants, such as RNA modifications and RNA-binding protein binding sites, may improve miRNA target prediction accuracy.
MOLECULES AND CELLS
(2023)
Review
Chemistry, Medicinal
Abolfazl Shakeri, Mohsen Gahnbari, Aida Tasbandi, Amirhossein Sahebkar
Summary: Natural products are a focus of research due to their pharmacological applications, chemical diversity, and low side effects, with some compounds showing anticancer activity and serving as sources for current anticancer drugs. The anticarcinogenic effects of natural products are partly mediated through microRNA-21 expression modulation.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Qiong Fan, Ting Huang, Xiao Sun, Xiaoming Yang, Jing Wang, Yao Liu, Ting Ni, Shenglan Gu, Yuhong Li, Yudong Wang
Summary: This study showed that miR-130a-3p may contribute to cervical cancer progression by suppressing ERα and AR, and could be a promising target for cervical cancer treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chen-Kai Chou, Shun-Yu Chi, Yi-Yung Hung, Yi-Chien Yang, Hung-Chun Fu, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Summary: The study revealed that dysregulated expression of miR-146b and androgen receptor (AR) played critical roles in the tumorigenesis of papillary thyroid carcinoma (PTC). It was confirmed that miR-146b expression was significantly inversely correlated with AR expression. Further experiments showed that AR might bind to the androgen receptor element on the promoter region of miR-146b, leading to repression of miR-146b expression and reduction of PTC tumor aggressiveness. PTC patients with low AR/high miR-146b expression were associated with advanced tumor characteristics.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Amirhossein Davoodvandi, Pouya Mahdavi Sharif, Parisa Maleki Dana, Zatollah Asemi
Summary: Gastrointestinal (GI) cancers are prevalent worldwide with increasing incidence. Treatment options for these cancers are limited and new strategies are needed. Resveratrol, a natural product found in fruits and plants, has been studied for its effects on microRNAs in neoplastic disorders. This review aims to illustrate the molecular pathways related to resveratrol and evaluate its impacts on microRNAs in the prevention and treatment of GI cancers.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Food Science & Technology
Fatemeh Sadoughi, Parisa Maleki Dana, Zatollah Asemi, Bahman Yousefi
Summary: Curcumin, as a beneficial plant compound, has the ability to modulate miRNA expression and have impacts on cancer hallmarks. MiRNAs are capable of regulating gene expression and signaling, as well as modulating cell differentiation and cell cycle, making them great candidates for personalized cancer treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Oncology
Matthew G. Cyr, Maissa Mhibik, Junpeng Qi, Haiyong Peng, Jing Chang, Erika M. Gaglione, David Eik, John Herrick, Thomas Venables, Scott J. Novick, Valentine V. Courouble, Patrick R. Griffin, Adrian Wiestner, Christoph Rader
Summary: This study identified highly potent and specific anti-Siglec-6 antibodies that can effectively target and kill Siglec-6(+) leukemic and healthy B cells, while sparing Siglec-6(-) healthy B cells. The T-biAb RC-1 demonstrated the best therapeutic efficacy, eliminating CLL cells at very low ratios and also showing toxicity against healthy B cells. These findings suggest Siglec-6 as a unique target for CLL treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Cardiac & Cardiovascular Systems
Goren Saenz-Pipaon, David A. Dichek
Summary: Discovered three decades ago, microRNAs (miRNAs) are now recognized as key players in the pathophysiology of multiple human diseases, including those affecting the cardiovascular system. As such, miRNAs have emerged as promising therapeutic targets for preventing the onset and/or progression of several cardiovascular diseases. The use of antagomirs, such as anti-miRNA antisense oligonucleotides, shows potential in precisely blocking specific miRNAs and treating major cardiovascular diseases. Recent advancements in antisense oligonucleotide chemistry and targeted delivery systems have improved efficacy and safety, providing hope for future clinical applications.
Article
Oncology
Rilan Bai, Jiuwei Cui
Summary: Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their metabolic pathways via mitochondria, which play crucial roles in the survival, immune evasion, tumor progression, and treatment resistance of the hypoxic tumor microenvironment. Targeting the mitochondria-related pathway with anticancer drugs can enhance the immune recognition of cancer cells, tumor antigen presentation ability, and anti-tumor function of immune cells. This review focuses on the effects of mitochondrial morphology and function on immune cells, the impact of mitochondrial changes on tumor immune escape and immune cell function, and the research progress and challenges of novel anti-tumor immunotherapy strategies targeting mitochondria.
Review
Biochemistry & Molecular Biology
Jing Li, Xianmei Zhong, Yueshui Zhao, Jing Shen, Chalermchai Pilapong, Zhangang Xiao
Summary: Lung cancer is the second leading cause of cancer-related death globally. Abnormal expression of microRNAs has been found in lung cancer and they play important roles in its initiation and progression. Polyphenols, natural bioactive chemicals synthesized by plants, have shown promising anticancer effects against lung cancer and other types of cancer. Recent studies have revealed that polyphenols exert their anticancer effects by regulating the expression levels of microRNAs in lung cancer. Therefore, targeting microRNAs using polyphenols may provide a novel strategy for the prevention and treatment of lung cancer.
Review
Biochemistry & Molecular Biology
Rebecca Raue, Ann-Christin Frank, Shahzad Nawaz Syed, Bernhard Brune
Summary: MiRs in the tumor microenvironment play crucial roles in regulating cancer progression and serve as potential targets for anti-tumor therapy, offering promising new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jui-Chieh Chen, Hsun-Chang Shih, Chih-Yang Lin, Jeng-Hung Guo, Cheng Huang, Hsiu-Chen Huang, Zhi-Yong Chong, Chih-Hsin Tang
Summary: Chondrosarcoma, the second most common bone cancer, is difficult to treat surgically when it is high-grade and metastatic. Doxorubicin (Dox) is commonly used in chemotherapy, but drug resistance hampers its effectiveness. This study found that the apelin (APLN) pathway is highly activated in Dox-resistant cells and in high-grade chondrosarcoma tissues. Inhibition of the APLN axis has shown therapeutic benefits in other cancers, and this study suggests that targeting APLN may improve the treatment of chondrosarcoma by overcoming drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Seong Ji Woo, Youngmi Kim, Harry Jung, Jae Jun Lee, Ji Young Hong
Summary: In this study, we found that miR-148a may protect against tuberculous pleural fibrosis by inhibiting the expression of NOX4 and POLDIP2, and reducing fibrogenesis and epithelial mesenchymal transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Zhao J. Lyu, Ying Wang, Jin L. Huang, Miao Chen, Sha Y. Wu, Qian Yan, Yu Zhang, Ying Tang, Chen Jiang, Lei Li, Yi Z. Jia, Yu C. Liu, Hong B. Mei, Feng Wang, Ren H. Li, Ya C. Chen, Xiang Lin, Zhi M. Cai, Xin Y. Guan
Summary: Urothelial carcinoma (UC) patients exhibit a significant prevalence (18%) of recurrent somatic mutations in the zinc finger protein gene ZNF83, with a hotspot mutation, p.E293V, showing correlation with poor prognosis and increased tumor growth. This mutation activates the NF-kappa B pathway, leading to enhanced tumor growth and decreased apoptosis. Inhibitors of NF-kappa B have been shown to pharmacologically block tumor growth in mice engrafted with UC cells expressing ZNF83-E293V, suggesting a potential therapeutic strategy for UC.
Article
Endocrinology & Metabolism
Dong Chen, Yawen Tan, Zhichao Li, Wujiao Li, Lei Yu, Wei Chen, Yuchen Liu, Lisa Liu, Liangfeng Guo, Weiren Huang, Yongsheng Zhao
Summary: Researchers established patient-derived PTC organoids as a promising new preclinical model for personalized therapy, demonstrating preservation of biological characteristics and genomic heterogeneity from the originating tumors and patient-specific drug responses.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Ganglin Su, Tianshu Liu, Xiaohong Han, Hao Sun, Wenan Che, Kun Hu, Junwen Xiao, Yanfeng Li, Yuchen Liu, Wujiao Li, Hongbing Mei
Summary: The study revealed that YTHDF2 may serve as a potential indicator of immune infiltration in KIRC and is associated with the overall survival and disease-free survival of patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Yuchen Liu, Tao Xu, Yonghao Zhan
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Letter
Oncology
Congcong Cao, Lin Yao, Aolin Li, Quan Zhang, Zhenan Zhang, Xiaofei Wang, Ying Gani, Yuchen Liu, Qian Zhang
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Yiqun Du, Tiantian Song, Jie Wu, Xiao-Dong Gao, Guanghui Ma, Yuchen Liu, Yufei Xia
Summary: This study developed mannosylated Pickering emulsions for targeted delivery of multiple effective components in cancer vaccines. The emulsion increased cellular targeting, cellular uptake, and activation, resulting in enhanced immune activation and potent anti-tumor effects. The strategic loading of components in the emulsion could serve as a targeted delivery platform for enhanced cancer vaccines.
Article
Chemistry, Multidisciplinary
Yiqun Du, Hongzhong Zhou, Ganglin Su, Mengdan Ma, Yuchen Liu
Summary: This study developed a protein corona-driven nanovaccine that effectively resists protein corona-induced antigen extracellular release and promotes antigen cytosolic release under reductive conditions. The nanovaccine demonstrated significant prophylactic and therapeutic antitumor response in a mouse model.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Cell Biology
Yonghao Zhan, Aolin Li, Congcong Cao, Yuchen Liu
Summary: In this study, the CRISPR signal conductor 2.0 was developed by integrating various lncRNA functional motifs into the CRISPR-dCas phi system. This system can directly regulate target gene expression and efficiently sense protein signals undetected by classical synthetic systems.
Article
Oncology
Chaojie Xu, Lishan Song, Yubin Yang, Yi Liu, Dongchen Pei, Jiabang Liu, Jianhua Guo, Nan Liu, Xiaoyong Li, Yuchen Liu, Xuesong Li, Lin Yao, Zhengjun Kang
Summary: This study comprehensively analyzed the role of M2 macrophages in tumor progression, identified two genes strongly correlated with LUAD prognosis, and constructed a prognostic nomogram with good performance. HRG patients were suitable for new ICI immunotherapy, while LRG was more suitable for CTLA4-immunosuppressive therapy alone.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Aolin Li, Congcong Cao, Ying Gan, Xiaofei Wang, Tianyu Wu, Quan Zhang, Yuchen Liu, Lin Yao, Qian Zhang
Summary: ZNF677 functions as a tumor suppressor in RCC and its low expression is associated with unfavorable prognosis and decreased m(6)A modification level. Furthermore, m(6)A modification regulates the translation and mRNA stability of ZNF677.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xinbo Huang, Mingxia Wang, Xia Wu, Yanfen Zou, Jinming Xu, Congcong Cao, Qian Ma, Bo Yu, Yuchen Liu, Yaoting Gui
Summary: In this study, a group of single-stranded DNA aptamers with high affinity and high specificity for the Cas9 protein were obtained. The aptamers were found to effectively regulate dCas9-modulated gene transcription and improve the efficiency of gene homologous recombination repair mediated by CRISPR-Cas9. These findings suggest a potential method to better control precise gene editing and enrich the diversity of modulating tools for the CRISPR-Cas9 system.
Article
Biochemistry & Molecular Biology
Congcong Cao, Aolin Li, Chaojie Xu, Baorui Wu, Jun Liu, Yuchen Liu
Summary: The CRISPR/dCasRx-SINEB2 technology has been developed to target translation of mRNAs using lncRNA functional elements. It has shown effective and adaptable results in increasing the expression of various proteins with minimal off-target effects. Additionally, it can prevent cancer cell proliferation and migration by targeting mRNA translation of antitumor proteins. This study provides an innovative protein enhancement method with multiple applications in biopharmaceutical production and cancer research.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yonghao Zhan, Congcong Cao, Aolin Li, Hongbing Mei, Yuchen Liu
Summary: This study demonstrates that the fusion of CasRx crRNA with an antisense ribozyme to construct a synthetic fusion guide RNA (CCRS) is more efficient for RNA knockdown and cancer gene therapy than conventional methods.
Article
Medicine, Research & Experimental
Hongzhong Zhou, Yiqun Du, Xiafei Wei, Chunli Song, Jianning Song, Nanson Xu, Weihong Huang, Lichan Chen, Fuwen Yao, Duanming Du, Chuanghua Qiu, Lihong Zhong, Yuchen Liu, Dayong Gu, Jin Wang, Yong Xu
Summary: This study found that DDX56 is upregulated in hepatocellular carcinoma (HCC) tissues and is strongly correlated with poor prognoses for HCC patients. DDX56 promotes HCC cell proliferation by interacting with MECOM to mono-methylate H3K9 on the MIST1 promoter. Furthermore, ZEB1 binds to DDX56 and transcriptionally activates DDX56, leading to HCC tumorigenesis.
Review
Oncology
Mengdan Ma, Yuchen Liu, Weiren Huang
Summary: The CRISPR-Cas system is a rapidly developing gene editing technology that has been widely used in various organisms, promoting the development of synthetic biology, genetics, and proteomics. This technology also accelerates the development of animal tumor models and plays a vital role in cancer research and treatment.
