Article
Oncology
Sisi Zhang, Lei Huo, Juan Zhang, Yayuan Feng, Yiping Liu, Yuxian Wu, Ningyang Jia, Wanmin Liu
Summary: This study aimed to develop and validate a preoperative model based on gadobenate-enhanced MRI for predicting MVI in patients with HCC. The model showed excellent predictive performance and clinical utility in both training and test sets. The HBP imaging features of gadobenate-enhanced MRI were found to be important in predicting MVI for HCC patients. The preoperative model could help clinicians assess the risk of MVI in HCC patients and optimize treatment options.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ali Mo, Qiao Zhang, Feng Xia, Zhiyuan Huang, Shasha Peng, Wenjing Cao, Hongliang Mei, Li Ren, Yang Su, Hengyi Gao, Weiqiang Chen
Summary: Preoperative TACE is found to be effective in improving the recurrence-free survival and overall survival for patients with solitary HCC (>= 10 cm) compared to those without preoperative TACE.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leyao Wang, Bing Feng, Dengfeng Li, Meng Liang, Shuang Wang, Sicong Wang, Xiaohong Ma, Xinming Zhao
Summary: This study aimed to evaluate the potential of preoperative MR imaging features and clinical parameters in risk stratification of patients with solitary HCC <= 5 cm without MVI after hepatectomy. The nomogram incorporating these risk factors showed good performance in predicting RFS and achieving risk stratification. Significant prognostic differences were found between high- and low-risk subgroups.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hong Wei, Hanyu Jiang, Tianying Zheng, Zhen Zhang, Caiwei Yang, Zheng Ye, Ting Duan, Bin Song
Summary: This study investigated the role of preoperative gadoxetic acid-enhanced MRI in stratifying the risk of early recurrence in LR-5 hepatocellular carcinoma patients after curative resection. Corona enhancement, peritumoral hypointensity on HBP, and satellite nodule were identified as significant MRI predictors for early recurrence. These findings can help stratify the risk of early recurrence in at-risk LR-5 HCC patients.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Eloy Ruiz, Pascal Pineau, Claudio Flores, Ramiro Fernandez, Luis Cano, Juan Pablo Cerapio, Sandro Casavilca-Zambrano, Francisco Berrospi, Ivan Chavez, Benjamin Roche, Stephane Bertani
Summary: The study aimed to construct a preoperative nomogram to predict long-term survival in patients with hepatocellular carcinoma (HCC) >10 cm. By analyzing clinical data from 234 patients and integrating factors such as cirrhosis, multifocality, macroscopic vascular invasion, and spontaneous tumor rupture into the nomogram model, the study successfully forecasted survival rates at 1, 3, and 5 years and stratified patients into three groups.
Article
Surgery
Ju-Dong Li, Yong-Kang Diao, Jie Li, Han Wu, Li-Yang Sun, Wei-Min Gu, Hong Wang, Ting-Hao Chen, Yong-Yi Zeng, Ya-Hao Zhou, Yu Wang, Yao-Ming Zhang, Ying-Jian Liang, Wan Yee Lau, Chao Li, Lei Liang, Ming-Da Wang, Cheng-Wu Zhang, Feng Shen, Cheng-Hao Shao, Tian Yang
Summary: The study found that preoperative prealbumin level was associated with postoperative mortality and morbidity for patients undergoing hepatic resection for HCC, with the low prealbumin group showing higher rates of adverse events. Prealbumin level could serve as an important predictor for postoperative outcomes in these patients.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Wen-Jia Cai, Minghua Ying, Rong-Qin Zheng, Jintang Liao, Baoming Luo, Lina Tang, Wen Cheng, Hong Yang, An Wei, Yilin Yang, Hui Wang, Yan-Chun Luo, Cun Liu, Hui Zhong, Qi Yang, Jie Yu, Ping Liang
Summary: The study evaluated the impact of HCC's biological characteristics on CEUS LI-RADS category and the outcomes after radical resection. Significant differences were found in the CEUS LI-RADS category based on differentiation and Ki-67 expression levels. However, no significant differences were observed between MVI and CEUS LI-RADS categories. Additionally, HCCs in different CEUS LI-RADS categories showed no significant differences in recurrence-free survival after resection.
Article
Surgery
Zong-qian Wu, Jie Cheng, Xi-xi Xiao, Hua-rong Zhang, Jian Wang, Juan Peng, Chen Liu, Ping Cai, Xiao-ming Li
Summary: This study aimed to investigate the significance of visceral adipose tissue index (VATI) as a risk factor for early recurrence (ER) of HBV-related hepatocellular carcinoma (HCC) (<= 5 cm) after hepatectomy. The results showed that VATI was an independent risk factor for ER and was closely related to poor outcomes after hepatectomy for HBV-related HCC (<= 5 cm).
FRONTIERS IN SURGERY
(2023)
Article
Oncology
Wen-juan Huang, Guang-yu Wang, Zeng-yao Liu, Meng-lin Zhang, Wen Wang, Xin Zhang, Rui-tao Wang
Summary: This study found a significant association between preoperative PDW levels and pulmonary metastasis (PM) after hepatectomy in HCC patients. PDW may serve as a biomarker for postoperative PM in HCC patients.
Article
Oncology
Leyao Wang, Xiaohong Ma, Bing Feng, Shuang Wang, Meng Liang, Dengfeng Li, Sicong Wang, Xinming Zhao
Summary: By utilizing radiomics features derived from preoperative multi-sequence MR images, combined with clinical and radiological risk factors, the individualized risk of early recurrence in patients with solitary hepatocellular carcinoma (HCC) ≤ 5 cm can be accurately predicted.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Feng Xia, Zhiyuan Huang, Qiao Zhang, Elijah Ndhlovu, Mingyu Zhang, Xiaoping Chen, Bixiang Zhang, Peng Zhu
Summary: This study assessed the impact of different tumor diameters on the posttreatment prognosis of BCLC stage 0/A ruptured hepatocellular carcinoma (rHCC) patients. The results showed that rHCC with a relatively small diameter can achieve a similar prognosis as non-ruptured HCC patients after aggressive treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi-Hao Yen, Wei-Feng Li, Yueh-Wei Liu, Chee-Chien Yong, Chih-Chi Wang, Chih-Yun Lin
Summary: This study developed a simple model to predict overall survival (OS) for patients undergoing liver resection (LR) for HCC >= 10 cm. The model utilized cirrhosis and imaging-defined AJCC stage as preoperative predictors. The results showed that cirrhosis and AJCC stage were independent predictors of OS in patients with HCC >= 10 cm who underwent LR.
Article
Oncology
Jiaqi Liang, Ying Feng, Yao Liu, Ke Shi, Guiqin Zhou, Long Liu, Yaxin Liu, Kexin Qiao, Wen Liu, Xianbo Wang
Summary: The study found that serum sDR5 level is an independent risk factor for mortality in patients with HBV-HCC, and accurately predicts patient prognosis. It is considered a new serological biomarker with high predictive accuracy. Serum sDR5 level is significantly associated with BCLC stage and the presence or absence of ascites.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Songping Cui, Shuang Cao, Qing Chen, Qiang He, Ren Lang
Summary: This study found that the preoperative inflammatory status plays a crucial role in the long-term prognosis of hepatocellular carcinoma (HCC) patients after liver transplantation (LT). Specifically, the preoperative inflammatory biomarkers SIRI and PLR can be used to predict the prognosis of HCC patients after LT.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Byung Chan Lee, Yong Yeon Jeong, Suk Hee Heo, Hyoung Ook Kim, Chan Park, Sang Soo Shin, Sung Bum Cho, Yang Seok Koh
Summary: The study suggests that multiplicity, central location, and marginal irregularity are important factors associated with poor prognosis in patients with early hepatocellular carcinoma after conventional TACE.
ACADEMIC RADIOLOGY
(2022)
Article
Surgery
Takeo Toshima, Tomoharu Yoshizumi, Yukiko Kosai-Fujimoto, Shoichi Inokuchi, Shohei Yoshiya, Kazuki Takeishi, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Masaki Mori
WORLD JOURNAL OF SURGERY
(2020)
Article
Oncology
Kazuki Takeishi, Tomoharu Yoshizumi, Shinji Itoh, Kyohei Yugawa, Shohei Yoshiya, Takeo Toshima, Noboru Harada, Toru Ikegami, Akihiro Nishie, Masaki Mori
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Surgery
A. Watanabe, T. Yoshizumi, N. Harimoto, K. Kogure, T. Ikegami, N. Harada, S. Itoh, K. Takeishi, Y. Mano, S. Yoshiya, A. Morinaga, K. Araki, N. Kubo, M. Mori, K. Shirabe
BRITISH JOURNAL OF SURGERY
(2020)
Article
Surgery
Noboru Harada, Tomoharu Yoshizumi, Hideaki Uchiyama, Toru Ikegami, Shinji Itoh, Kazuki Takeishi, Takeo Toshima, Yoshihiro Nagao, Shohei Yoshiya, Masaki Mori
CLINICAL TRANSPLANTATION
(2020)
Article
Pathology
Kyohei Yugawa, Shinji Itoh, Tomoharu Yoshizumi, Shohei Yoshiya, Kazuki Takeishi, Takeo Toshima, Noboru Harada, Toru Ikegami, Kenichi Kohashi, Yoshinao Oda, Masaki Mori
PATHOLOGY INTERNATIONAL
(2020)
Article
Surgery
Katsuya Toshida, Ryosuke Minagawa, Hiroto Kayashima, Shohei Yoshiya, Tadashi Koga, Kiyoshi Kajiyama, Tomoharu Yoshizumi, Masaki Mori
WORLD JOURNAL OF SURGERY
(2020)
Article
Surgery
Daisuke Imai, Takashi Maeda, Huanlin Wang, Tomonari Shimagaki, Kensaku Sanefuji, Hiroto Kayashima, Shinichi Tsutsui, Hiroyuki Matsuda, Tomoharu Yoshizumi, Masaki Mori
Summary: Higher intraoperative blood loss during liver resection is significantly associated with increased morbidity and mortality in patients with primary hepatocellular carcinoma. Factors such as tumor size, serum creatinine, clinically significant portal hypertension, and major hepatectomy are significant predictors of intraoperative blood loss.
Article
Oncology
Mizuki Ninomiya, Yasunori Emi, Takashi Motomura, Takahiro Tomino, Tomohiro Iguchi, Hiroto Kayashima, Noboru Harada, Hideaki Uchiyama, Takashi Nishizaki, Hidefumi Higashi, Hiroyuki Kuwano
Summary: The study suggests that patients with synchronous and Grade B/C colorectal liver metastases may benefit from neoadjuvant chemotherapy before surgery.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Katsuya Toshida, Shinji Itoh, Kyohei Yugawa, Yukiko Kosai, Takahiro Tomino, Shohei Yoshiya, Yoshihiro Nagao, Hiroto Kayashima, Noboru Harada, Kenichi Kohashi, Yoshinao Oda, Tomoharu Yoshizumi
Summary: This study found that the FGFR2 fusion gene is frequently found in patients with ICC and the FGFR2 high expression is an independent prognostic factor for the recurrence of resected ICC.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Katsuya Toshida, Shinji Itoh, Hiroto Kayashima, Yoshihiro Nagao, Shohei Yoshiya, Takahiro Tomino, Yukiko Kosai Fujimoto, Yuriko Tsutsui, Yuki Nakayama, Noboru Harada, Tomoharu Yoshizumi
Summary: The study found that a low HALP score is an independent prognostic factor for patients with hepatocellular carcinoma.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Woo-Hyoung Kang, Shin Hwang, Masaki Kaibori, Jong Man Kim, Kyung Sik Kim, Tsuyoshi Kobayashi, Hiroto Kayashima, Yang Seok Koh, Keiichi Kubota, Akira Mori, Yutaka Takeda, Sung Su Yun, Kousuke Matsui, Kan Toriguchi, Hiroaki Nagano, Myung Hee Yoon, Yuji Soejima, Shunichi Ariizumi, Bum-Soo Kim, Yohan Park, Hee Chul Yu, Bong Wan Kim, Jung Bok Lee, Sang-Jae Park, Jin-Young Jang, Hiroki Yamaue, Masafumi Nakamura, Masakazu Yamamoto, Itaru Endo
Summary: The ADV score, calculated from the concentrations of AFP, DCP, and TV, has been shown to be prognostic of HCC recurrence following HR or liver transplantation. This international validation study demonstrated that ADV score is an integrated surrogate biomarker for post-resection prognosis of HCC.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Jin Shiraishi, Shinji Itoh, Takahiro Tomino, Shohei Yoshiya, Yoshihiro Nagao, Hiroto Kayashima, Noboru Harada, Ichiro Sakamoto, Hiroyuki Tsutsui, Tomoharu Yoshizumi
Summary: In this study, three cases of HCC in patients with Fontan-associated liver disease were described. Different surgical treatments were performed on these patients, resulting in different outcomes in preventing HCC recurrence. Furthermore, it was found that a high preoperative alpha-fetoprotein concentration might serve as a predictor for HCC recurrence, based on a review of 18 surgical cases of HCC arising from Fontan-associated liver disease, including the three cases mentioned.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Tomohiro Iguchi, Takashi Motomura, Hideaki Uchiyama, Norifumi Iseda, Rintaro Yoshida, Hiroto Kayashima, Noboru Harada, Mizuki Ninomiya, Keishi Sugimachi, Takuya Honboh, Takashi Maeda, Noriaki Sadanaga, Hiroshi Matsuura
Summary: This study retrospectively analyzed data from 65 patients with soft pancreatic texture and found that the use of a 7.5-Fr pancreatic duct stent may reduce the incidence of postoperative pancreatic fistula (POPF). POPF was negatively correlated with pancreatic duct stent size, and male patients were more prone to develop POPF.
Article
Surgery
Hiroto Kayashima, Ryosuke Minagawa, Shoichi Inokuchi, Tadashi Koga, Nobutoshi Miura, Kiyoshi Kajiyama
Summary: MALS is a rare condition that can be treated by releasing the MAL surgically, and asymptomatic MALS may not require ganglionectomy of the celiac plexus. Surgical treatment typically ensures normal blood flow for patients.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Gastroenterology & Hepatology
Yusuke Yonemura, Tomoharu Yoshizumi, Shoichi Inokuchi, Yukiko Kosai-Fujimoto, Noboru Harada, Shinji Itoh, Takeo Toshima, Kazuki Takeishi, Shohei Yoshiya, Masaki Mori
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2020)
