Article
Oncology
Linjing Li, Xin Li, Qingyan Zhang, Tao Ye, Shuli Zou, Jing Yan
Summary: The study demonstrated that EIF5A is highly expressed in HCC tissues and significantly correlated with histological grade, clinical stage, and pT stage, indicating it could be a potential biomarker for HCC.
Article
Immunology
Yue Zhang, Sihua Zhang, Jianhua Liu, Yunli Zhang, Yanjie Liu, Shuang Shen, Fangfang Tian, Gaobo Yan, Yongqing Gao, Xiaosong Qin
Summary: This study used lectin microarrays to evaluate the differences in serum immunoglobulin (Ig)G and IgM glycosylation among patients with hepatocellular carcinoma (HCC), hepatitis B cirrhosis (HBC), chronic hepatitis B (CHB), and healthy normal controls (NC). The results showed that the estimation of serum IgG and IgM glycosylation could act as complementary techniques to improve the diagnosis of HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qian Yang, Hua Ye, Guiying Sun, Keyan Wang, Liping Dai, Cuipeng Qiu, Jianxiang Shi, Jicun Zhu, Xiao Wang, Peng Wang
Summary: This study aimed to identify potential autoantibodies to tumor-associated antigens (TAAbs) for hepatocellular carcinoma (HCC) detection. Eight TAAbs were validated and used to construct an immunodiagnostic model with an AUC of 0.835 and 0.788 in the training and validation sets, respectively. The study also observed an increase in TAAbs levels during HCC formation in mouse serum samples. In conclusion, the panel of six TAAbs shows potential value for HCC detection and provides new insights into immunodiagnostic biomarkers.
MOLECULAR ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Linping Xu, Hui Yang, Meimei Yan, Wei Li
Summary: This study found that MMP1 is a poor prognostic and predominant biomarker for patients with HCC. Anti-MMP1 may be a novel therapy worth studying.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Jinxu Wen, Xiaoru Qin, Jiayi Zhang, Xiaoyong Wu, Xuemin Yan, Kewen Lu, Pei Yang, Shuaichong Ji, Xiangdong Zhao, Yuexin Wang
Summary: This study investigated the relationship between MMP-9 expression and pathological indexes in PTC. Results showed that MMP-9 expression was significantly correlated with lymph node metastasis, tumor size, and TNM stage, but not with gender and age. MMP-9 may serve as a reliable prognostic biomarker for PTC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Hui Wang, Hong Li, Qingtao Yan, Sumei Gao, Jianfang Gao, Zhenhua Wang, Yi Sun
Summary: Serum MMP-13 levels are significantly higher in patients with cSCC compared to healthy controls, particularly in those with invasive cSCC. Surgical removal of cSCC results in a significant decrease in serum MMP-13 levels. Serum MMP-13 can predict the invasiveness of cSCC and lymph node involvement with high sensitivity and specificity.
Article
Clinical Neurology
Giuseppe Cosentino, Vincenzo Di Stefano, Rosalia Lo Presti, Maria Montana, Massimiliano Todisco, Matteo Gastaldi, Andrea Cortese, Enrico Alfonsi, Cristina Tassorelli, Brigida Fierro, Gregorio Caimi, Filippo Brighina
Summary: This study found that the plasmatic levels of MMPs and TIMPs were significantly altered in patients with CIDP, with higher concentrations of MMP-9, downregulation of TIMP-1, and lower concentration of MMP-2. These new biomarkers may have potential usefulness in the clinical setting and further studies are needed to confirm their utility.
NEUROLOGICAL SCIENCES
(2021)
Article
Oncology
Philipp Kohn, Alexandros Lalos, Alberto Posabella, Alexander Wilhelm, Athanasios Tampakis, Ercan Caner, Uwe Guth, Sylvia Stadlmann, Giulio C. Spagnoli, Salvatore Piscuoglio, Sabine Richarz, Tarik Delko, Raoul A. Droeser, Gad Singer
Summary: High expression of CXCL12 in immune cells is associated with better chemosensitivity, overall survival, and longer recurrence-free survival in patients with high-grade serous ovarian carcinoma. Additionally, combined high density of CXCL12 and CD66b immune cells is an independent favorable predictor of recurrence-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cui Yang, Xiao-Qin Wei, Jing Zheng, Yun-Yun Tao, Xue-Qin Gong, Li Li, Zu-Mao Li, Lin Yang, Qi Mao, Mao-Ting Zhou, Xiao-Ming Zhang
Summary: This study provides a preliminary analysis of the correlation between IVIM-DWI parameters and the expression of VEGF, MMP-2, and MMP-9 to investigate the value of IVIM-DWI in the noninvasive evaluation of angiogenesis in HCC.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Pharmacology & Pharmacy
Yamin Jie, Guijun Liu, E. Mingyan, Ying Li, Guo Xu, Jingjing Guo, Yinyin Li, Guanghua Rong, Yongwu Li, Anxin Gu
Summary: This study identified novel small molecule inhibitors of ETS-1 for HCC treatment and demonstrated that compounds similar to EI-4 can effectively inhibit the activation of ETS-1 and reduce proliferation and invasion of HCC cells. These findings provide valuable insights for developing safer and more effective molecular therapy strategies for HCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yufei Chen, Chenfeng Mao, Rui Gu, Rujia Zhao, Weihao Li, Zihan Ma, Yiting Jia, Fang Yu, Jian Luo, Yi Fu, Jinpeng Sun, Wei Kong
Summary: Nidogen-2 is an endogenous ligand of LGR4 that inhibits vascular calcification by activating a specific signaling pathway.
CIRCULATION RESEARCH
(2022)
Review
Oncology
Nathalie Theret, Fidaa Bouezzeddine, Fida Azar, Mona Diab-Assaf, Vincent Legagneux
Summary: Members of the adamalysin family, including ADAM, ADAMTS, and ADAMTSL, play critical roles in modulating cell-cell and cell-ECM communication within the tumor microenvironment, influencing hepatocellular carcinoma progression. The tumor microenvironment, consisting of stromal cells, ECM, and cytokine/growth factors, is essential for tumor growth, invasion, and resistance to chemotherapy. Despite numerous studies supporting the involvement of adamalysins in HCC development, the functional characterization of most of them remains unresolved.
Article
Cell Biology
Chaoguang Luan, Ying Xu
Summary: Telocytes play a crucial role in promoting the metastasis of hepatocellular carcinoma (HCC) by overexpressing matrix metalloproteinases (MMPs), but the mechanism of MMP secretion in TCs remains unknown. In this study, TCs were cultured from liver cancer tissues and surrounding tissues. SNP mutations related to MMPs were identified, and high levels of MMP1, MMP7, and MMP9 were associated with poor overall survival in HCC. These findings suggest that TCs may contribute to the development of HCC by regulating an interactive network of MMPs.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)