Article
Surgery
Zhao-liang Yu, Xuan-hui Liu, Hua-shan Liu, Jia Ke, Yi-feng Zou, Wu-teng Cao, Jian Xiao, Zhi-yang Zhou, Ping Lan, Xiao-jian Wu, Xian-rui Wu
Summary: The study evaluated the impact of pelvic dimensions on the risk of anastomotic leak in rectal cancer patients. The results showed that pelvic inlet and intertuberous distance were independent predictors for postoperative anastomotic leak. The incorporation of pelvic dimensions with other factors in the nomogram may provide a clinical tool for predicting anastomotic leak.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Nynke G. Greijdanus, Kiedo Wienholts, Sander Ubels, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Francisco B. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Yves Panis, Martin Rutegard, Roel Hompes, Camiel Rosman, Frans van Workum, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: The study developed a prediction model for 1-year stoma-free survival in rectal cancer patients with anastomotic leakage. The model, consisting of 18 clinically relevant factors, showed good discrimination and calibration, providing guidance for patient counseling and future treatment strategies analysis.
Article
Gastroenterology & Hepatology
Frans van Workum, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Borja F. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo Oliva Perez, Tsuyoshi Konishi, Yves Panis, Camiel Rosman, Roel Hompes, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: This study aims to investigate the factors contributing to the severity of anastomotic leakage after low anterior resection for rectal cancer, create a severity score, and evaluate the effects of different treatment approaches on outcome parameters. The international multicentre retrospective cohort study, TENTACLE-Rectum, will provide valuable evidence-based recommendations for improving outcomes in patients with severe treatment-related morbidity.
COLORECTAL DISEASE
(2021)
Article
Multidisciplinary Sciences
Tingzhen Li, Jianglong Huang, Purun Lei, Xiaofeng Yang, Zehong Chen, Peng Chen, Jiancheng Zhai, Xuefeng Guo, Hongbo Wei
Summary: This study aimed to identify the risk factors and develop a prediction model for anastomotic leakage in rectal cancer patients. The results showed that preoperative bowel obstruction and early first defecation after surgery were independent risk factors. The nomogram prediction model had good predictive ability, which could guide treatment and surgical decision-making.
Article
Oncology
V. T. Hoek, S. Buettner, C. L. Sparreboom, R. Detering, A. G. Menon, G. J. Kleinrensink, M. W. J. M. Wouters, J. F. Lange, J. K. Wiggers
Summary: This study aimed to develop a robust preoperative prediction model for anastomotic leakage after surgical resection for rectal cancer. Significant risk factors were identified and included in the prediction model, which can be used for patient counselling and risk-stratification before undergoing rectal resection for cancer.
Article
Surgery
Thomas W. A. Koedam, Boukje T. Bootsma, Charlotte L. Deijen, Tim van de Brug, Geert Kazemier, Miguel A. Cuesta, Alois Furst, Antonio M. Lacy, Eva Haglind, Jurriaan B. Tuynman, Freek Daams, Hendrik J. Bonjer
Summary: Anastomotic leakage after rectal cancer surgery negatively affects long-term oncological outcomes, leading to increased local recurrences and decreased disease-free survival. However, its impact on outcomes after colon cancer surgery remains inconclusive.
Article
Oncology
Chuangkun Li, Weiwen Liang, Lili Chu, Yingqi Wei, Xiusen Qin, Zifeng Yang, Wentai Guo, Hui Wang, Huaiming Wane, Rongkang Huang
Summary: The main risk factors for anastomotic leakage in elderly rectal cancer patients after surgery include American Society of Anesthesiologists score >= 3, male sex, and neoadjuvant radiotherapy. Combining these factors can accurately predict the occurrence of anastomotic leakage. The nomogram developed in this study has a moderate predictive ability.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Surgery
Jung Cheol Kuk, Dae Ro Lim, Eung Jin Shin
Summary: This study retrospectively analyzed data from 556 patients with rectal cancer and found that the placement of a transanal drainage tube (TDT) can reduce the occurrence of anastomotic leakage (AL) following low anterior resection (LAR). Logistic analysis identified the non-use of a TDT as a risk factor for AL.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Liang Yu, Guangliang Chen, Hua Wang, Xiaojie Wang, Zhifen Chen, Ying Huang, Pan Chi
Summary: This study evaluated the feasibility and diagnostic accuracy of magnetic resonance imaging (MRI) in early detection of anastomotic leakage (AL) in patients with suspected AL after rectal anterior resection. The results showed favorable sensitivity and specificity of MRI in diagnosing AL.
Article
Gastroenterology & Hepatology
Wei Jiang, Huaiming Wang, Jixiang Zheng, Yandong Zhao, Shuoyu Xu, Shuangmu Zhuo, Hui Wang, Jun Yan
Summary: This study aimed to quantitatively analyze collagen structural changes caused by preoperative chemoradiotherapy and investigate the relationship between collagen changes and anastomotic leakage (AL). The results showed that preoperative chemoradiotherapy significantly increased the risk of AL. The study also developed an AL-SVM classifier to predict the risk of AL in rectal cancer patients undergoing preoperative chemoradiotherapy.
GASTROENTEROLOGY REPORT
(2022)
Article
Gastroenterology & Hepatology
Kevin Talboom, Nynke G. Greijdanus, Frans van Workum, Sander Ubels, Camiel Rosman, Roel Hompes, Johannes H. W. de Wilt, Pieter J. Tanis
Summary: This study investigated the preferred treatment for anastomotic leakage after low anterior resection for rectal cancer by expert colorectal surgeons worldwide. The results showed that early leaks in septic patients were treated preferentially by major salvage surgery, while early leaks in non-septic patients were treated with drainage and fecal diversion. Late leaks had a wide range of treatment options, with minimal influence of symptoms on the proposed strategy. Treatment strategies for leaks of the blind loop and rectovaginal fistulae varied greatly.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Florian Ponholzer, Clemens Paul Klingler, Elisabeth Gasser, Philipp Gehwolf, Marijana Ninkovic, Ruben Bellotti, Reinhold Kafka-Ritsch, Dietmar Oefner
Summary: This study analyzed the prevalence and factors influencing chronic anastomotic leakage after low anterior resection for rectal cancer, as well as the treatment of persisting presacral sinus and the impact of stoma reversal on outcome. The results showed that neoadjuvant radiochemotherapy or chemotherapy had a significant impact on the formation of chronic anastomotic leakage, while initial surgical treatment showed no difference in anastomotic healing but had a better overall survival. Multiple therapies and surgical revision had a negative impact on natural bowel continuity. Additionally, stoma reversal showed improved overall survival and functional results.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Biochemical Research Methods
Xiaowen Qiao, Xinyu Qi, Pu Xing, Tianqi Liu, Hao Hao, Xinying Yang, Beihai Jiang, Ming Cui, Xiangqian Su
Summary: Anastomotic leakage (AL) is a severe complication in rectal surgery, and early diagnosis remains challenging. This study identified potential biomarkers for early diagnosis of AL by analyzing protein expression profiles in patients who underwent surgery for rectal cancer.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Surgery
Vladimir Bencurik, Matej Skrovina, Lubomir Martinek, Jiri Bartos, Maria Machackova, Michal Dosoudil, Erika Stepanova, Lenka Pribylova, Radim Bris, Katherine Vomackova
Summary: The study showed that using ICG to visualize tissue perfusion in low rectal resections for cancer can significantly reduce the incidence of AL. Diabetes and the application of a transanal drain (NoCoil) were identified as additional risk factors for AL.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Zheng Yao, Weiliang Tian, Ming Huang, Xin Xu, Risheng Zhao
Summary: The study investigated the effect of placing double-lumen irrigation-suction tubes (DLIST) on the closure of anastomotic defect (AD) after rectal cancer surgery. The results showed that placement of DLIST might be an effective method for treating AD following rectal cancer surgery, with higher closure rate and lower length of stay and treatment costs compared to passive drainage (PD).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)